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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.


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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ciao1 cytosolic iron-sulfur protein assembly 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 2:127,082,858...127,089,736
Ensembl chr 2:127,082,858...127,089,736 		JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 9:66,033,878...66,046,250
Ensembl chr 9:66,033,893...66,046,237 		JBrowse link
G Ciao2b cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 8:105,366,471...105,368,360
Ensembl chr 8:105,366,470...105,368,597 		JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr17:25,992,750...26,002,306
Ensembl chr17:25,992,750...26,002,306 		JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 8:95,546,446...95,565,454
Ensembl chr 8:95,546,432...95,564,986 		JBrowse link
G Mms19 MMS19 cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr19:41,932,146...41,969,603
Ensembl chr19:41,929,525...41,969,596 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 2:25,134,825...25,145,458
Ensembl chr 2:25,134,833...25,146,034
Ensembl chr 2:25,134,833...25,146,034
Ensembl chr 2:25,134,833...25,146,034 		JBrowse link
G Nubp1 nucleotide binding protein 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr16:10,229,802...10,242,317
Ensembl chr16:10,229,812...10,242,292 		JBrowse link
G Nubp2 nucleotide binding protein 2 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr17:25,101,585...25,105,423
Ensembl chr17:25,101,585...25,105,323 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP-binding cassette, sub-family B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chr  X:103,324,171...103,457,452
Ensembl chr  X:103,324,263...103,457,462 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chr17:24,912,164...24,915,065
Ensembl chr17:24,912,161...24,915,503 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bola3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:83,326,129...83,337,118
Ensembl chr 6:83,326,129...83,337,118 		JBrowse link
G Fdx1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 9:51,854,323...51,874,902
Ensembl chr 9:51,854,606...51,874,856 		JBrowse link
G Fdx2 ferredoxin 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 9:20,978,808...20,984,827
Ensembl chr 9:20,978,816...20,984,910 		JBrowse link
G Fdxr ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chr11:115,158,850...115,167,925
Ensembl chr11:115,158,850...115,167,876 		JBrowse link
G Glrx5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:104,998,877...105,007,170
Ensembl chr12:104,998,947...105,009,165 		JBrowse link
G Hscb HscB iron-sulfur cluster co-chaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chr 5:110,976,945...110,987,647
Ensembl chr 5:110,976,936...110,987,643 		JBrowse link
G Hspa9 heat shock protein 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Iba57 IBA57 homolog, iron-sulfur cluster assembly ISO RGD PMID:25245479 RGD:11554190 NCBI chr11:59,046,194...59,055,391
Ensembl chr11:59,046,195...59,054,565 		JBrowse link
G Isca1 iron-sulfur cluster assembly 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr13:59,903,229...59,917,603
Ensembl chr13:59,903,223...59,917,624 		JBrowse link
G Isca2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:84,820,007...84,821,863
Ensembl chr12:84,820,025...84,821,862 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chr 5:113,910,479...113,916,349
Ensembl chr 5:113,910,809...113,916,349 		JBrowse link
G Lyrm4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chr13:36,162,778...36,301,543
Ensembl chr13:36,162,378...36,301,509 		JBrowse link
G Nfs1 nitrogen fixation gene 1 (S. cerevisiae) ISO RGD PMID:25245479 RGD:11554190 NCBI chr 2:155,965,569...155,986,106
Ensembl chr 2:155,965,559...155,986,106 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:86,986,040...87,005,443
Ensembl chr 6:86,986,218...87,005,443 		JBrowse link
G Nubpl nucleotide binding protein-like ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:52,144,529...52,357,753
Ensembl chr12:52,144,520...52,359,527 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    classic metabolic pathway 1858
      metabolic pathway of cofactors, vitamins, nutrients 391
        iron-sulfur cluster protein biogenesis pathway 26
          cytosolic iron-sulfur cluster protein assembly pathway 9
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 15
Path 2
Term Annotations click to browse term
  pathway 6074
    regulatory pathway 3686
      homeostasis pathway 1721
        inorganic chemical homeostasis pathway 294
          metal homeostasis pathway 202
            iron homeostasis pathway 62
              iron utilization pathway 37
                iron-sulfur cluster protein biogenesis pathway 26
                  cytosolic iron-sulfur cluster protein assembly pathway 9
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 15
paths to the root