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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.


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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CIAO1 cytosolic iron-sulfur assembly component 1 TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 2:96,266,225...96,274,173
Ensembl chr 2:96,266,159...96,274,173 		JBrowse link
G CIAO2A cytosolic iron-sulfur assembly component 2A TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr15:64,072,565...64,093,838
Ensembl chr15:64,072,565...64,094,262 		JBrowse link
G CIAO2B cytosolic iron-sulfur assembly component 2B TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr16:66,932,065...66,934,402
Ensembl chr16:66,932,065...66,934,423 		JBrowse link
G CIAO3 cytosolic iron-sulfur assembly component 3 TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr16:729,765...740,997
Ensembl chr16:729,760...741,329 		JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr16:57,428,187...57,447,385
Ensembl chr16:57,428,187...57,447,420 		JBrowse link
G MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr10:97,458,324...97,498,794
Ensembl chr10:97,458,324...97,498,794 		JBrowse link
G NDOR1 NADPH dependent diflavin oxidoreductase 1 TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 9:137,205,700...137,219,361
Ensembl chr 9:137,205,685...137,219,361 		JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr16:10,743,842...10,769,351
Ensembl chr16:10,743,786...10,769,351 		JBrowse link
G NUBP2 NUBP iron-sulfur cluster assembly factor 2, cytosolic TAS RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr16:1,782,960...1,789,186
Ensembl chr16:1,782,932...1,789,186 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 TAS RGD PMID:25245479 RGD:11554190 NCBI chr  X:75,051,048...75,156,283
Ensembl chr  X:75,051,048...75,156,732 		JBrowse link
G GFER growth factor, augmenter of liver regeneration TAS RGD PMID:25245479 RGD:11554190 NCBI chr16:1,984,193...1,987,749
Ensembl chr16:1,984,193...1,987,749 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOLA3 bolA family member 3 TAS RGD PMID:25245479 RGD:11554190 NCBI chr 2:74,135,400...74,147,912
Ensembl chr 2:74,135,400...74,147,912 		JBrowse link
G FDX1 ferredoxin 1 TAS RGD PMID:25245479 RGD:11554190 NCBI chr11:110,429,331...110,464,884
Ensembl chr11:110,429,948...110,464,884 		JBrowse link
G FDX2 ferredoxin 2 TAS RGD PMID:25245479 RGD:11554190 NCBI chr19:10,310,045...10,316,015
Ensembl chr19:10,309,916...10,316,015 		JBrowse link
G FDXR ferredoxin reductase TAS RGD PMID:25245479 RGD:11554190 NCBI chr17:74,862,497...74,872,994
Ensembl chr17:74,862,497...74,873,031 		JBrowse link
G GLRX5 glutaredoxin 5 TAS RGD PMID:25245479 RGD:11554190 NCBI chr14:95,535,050...95,544,714
Ensembl chr14:95,533,503...95,544,724 		JBrowse link
G HSCB HscB mitochondrial iron-sulfur cluster cochaperone TAS RGD PMID:25245479 RGD:11554190 NCBI chr22:28,742,032...28,757,510
Ensembl chr22:28,742,039...28,757,515 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 TAS RGD PMID:25245479 RGD:11554190 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675 		JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 TAS RGD PMID:25245479 RGD:11554190 NCBI chr 1:228,165,804...228,182,257
Ensembl chr 1:228,165,804...228,182,257 		JBrowse link
G ISCA1 iron-sulfur cluster assembly 1 TAS RGD PMID:25245479 RGD:11554190 NCBI chr 9:86,264,546...86,282,538
Ensembl chr 9:86,264,546...86,283,102 		JBrowse link
G ISCA2 iron-sulfur cluster assembly 2 TAS RGD PMID:25245479 RGD:11554190 NCBI chr14:74,493,765...74,497,106
Ensembl chr14:74,493,756...74,497,106 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme TAS RGD PMID:25245479 RGD:11554190 NCBI chr12:108,561,463...108,569,384
Ensembl chr12:108,562,582...108,569,368 		JBrowse link
G LYRM4 LYR motif containing 4 TAS RGD PMID:25245479 RGD:11554190 NCBI chr 6:5,031,753...5,260,950
Ensembl chr 6:5,103,629...5,260,950 		JBrowse link
G NFS1 NFS1 cysteine desulfurase TAS RGD PMID:25245479 RGD:11554190 NCBI chr20:35,668,052...35,699,352
Ensembl chr20:35,668,052...35,699,355 		JBrowse link
G NFU1 NFU1 iron-sulfur cluster scaffold TAS RGD PMID:25245479 RGD:11554190 NCBI chr 2:69,395,750...69,439,567
Ensembl chr 2:69,396,113...69,437,628 		JBrowse link
G NUBPL NUBP iron-sulfur cluster assembly factor, mitochondrial TAS RGD PMID:25245479 RGD:11554190 NCBI chr14:31,561,404...31,861,224
Ensembl chr14:31,489,956...31,861,224 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    classic metabolic pathway 1803
      metabolic pathway of cofactors, vitamins, nutrients 370
        iron-sulfur cluster protein biogenesis pathway 26
          cytosolic iron-sulfur cluster protein assembly pathway 9
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 15
Path 2
Term Annotations click to browse term
  pathway 5957
    regulatory pathway 3600
      homeostasis pathway 1667
        inorganic chemical homeostasis pathway 293
          metal homeostasis pathway 201
            iron homeostasis pathway 62
              iron utilization pathway 37
                iron-sulfur cluster protein biogenesis pathway 26
                  cytosolic iron-sulfur cluster protein assembly pathway 9
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 15
paths to the root