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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.

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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CIAO1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr14:685,378...690,752
Ensembl chr14:685,321...690,544 		JBrowse link
G CIAO2A cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr26:19,448,702...19,470,212
Ensembl chr26:19,448,903...19,469,756 		JBrowse link
G CIAO2B cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 5:52,631,539...52,633,949
Ensembl chr 5:52,631,354...52,633,856 		JBrowse link
G CIAO3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 5:649,457...661,085
Ensembl chr 5:650,100...660,518 		JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 5:43,360,465...43,378,561
Ensembl chr 5:43,359,399...43,378,686 		JBrowse link
G MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 9:90,629,148...90,670,113
Ensembl chr 9:90,629,511...90,669,019 		JBrowse link
G NDOR1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr12:970,256...983,893
Ensembl chr12:973,078...983,791 		JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 5:10,224,965...10,248,328
Ensembl chr 5:10,225,173...10,249,047 		JBrowse link
G NUBP2 NUBP iron-sulfur cluster assembly factor 2, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 5:1,687,972...1,697,559
Ensembl chr 5:1,691,565...1,697,562 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chr  X:64,633,989...64,748,638
Ensembl chr  X:64,634,079...64,701,938 		JBrowse link
G GFER growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chr 5:1,880,025...1,886,829
Ensembl chr 5:1,879,968...1,883,696 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOLA3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:33,130,549...33,142,878
Ensembl chr14:33,130,579...33,143,019 		JBrowse link
G FDX1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 1:101,777,499...101,813,753
Ensembl chr 1:101,777,678...101,816,379 		JBrowse link
G FDX2 ferredoxin 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:9,359,446...9,364,702
Ensembl chr 6:9,359,719...9,364,689 		JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chr16:46,785,669...46,796,154
Ensembl chr16:46,785,591...46,796,187 		JBrowse link
G GLRX5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chr24:73,387,941...73,398,208
Ensembl chr24:73,387,641...73,398,233 		JBrowse link
G HSCB HscB mitochondrial iron-sulfur cluster cochaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chr19:11,621,205...11,639,750
Ensembl chr19:11,621,420...11,636,396 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chr23:41,230,675...41,251,177
Ensembl chr23:41,231,364...41,251,150 		JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chr25:1,531,030...1,563,180 JBrowse link
G ISCA1 iron-sulfur cluster assembly 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:96,900,619...96,915,611
Ensembl chr12:96,897,849...96,915,540 		JBrowse link
G ISCA2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr24:51,700,941...51,702,680
Ensembl chr24:51,700,991...51,702,211 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chr11:103,753,175...103,760,168
Ensembl chr11:103,753,189...103,760,364 		JBrowse link
G LYRM4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chr17:66,921,386...67,077,331
Ensembl chr17:66,921,596...67,076,843 		JBrowse link
G NFS1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chr 2:56,592,304...56,617,510
Ensembl chr 2:56,592,308...56,617,469 		JBrowse link
G NFU1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:37,690,329...37,731,093
Ensembl chr14:37,690,656...37,730,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    classic metabolic pathway 1004
      metabolic pathway of cofactors, vitamins, nutrients 233
        iron-sulfur cluster protein biogenesis pathway 25
          cytosolic iron-sulfur cluster protein assembly pathway 9
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 14
Path 2
Term Annotations click to browse term
  pathway 4028
    regulatory pathway 2488
      homeostasis pathway 1295
        inorganic chemical homeostasis pathway 287
          metal homeostasis pathway 197
            iron homeostasis pathway 60
              iron utilization pathway 36
                iron-sulfur cluster protein biogenesis pathway 25
                  cytosolic iron-sulfur cluster protein assembly pathway 9
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 14
paths to the root