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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.


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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CIAO1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr17:34,507,136...34,512,566
Ensembl chr17:34,508,662...34,512,486 		JBrowse link
G CIAO2A cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr30:28,582,048...28,597,856
Ensembl chr30:28,582,902...28,597,748 		JBrowse link
G CIAO2B cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 5:82,384,719...82,386,655
Ensembl chr 5:82,384,756...82,386,540 		JBrowse link
G CIAO3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 6:39,846,782...39,853,952
Ensembl chr 6:39,846,856...39,853,956 		JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 2:58,977,592...58,992,785
Ensembl chr 2:58,977,676...58,992,581 		JBrowse link
G MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr28:10,749,327...10,783,846
Ensembl chr28:10,749,325...10,783,805 		JBrowse link
G NDOR1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 9:48,456,256...48,464,930
Ensembl chr 9:48,455,260...48,464,970 		JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 6:31,900,540...31,922,087
Ensembl chr 6:31,896,596...31,921,989 		JBrowse link
G NUBP2 NUBP iron-sulfur cluster assembly factor 2, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 6:39,119,332...39,121,869
Ensembl chr 6:39,119,337...39,122,370 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chr  X:58,305,804...58,470,827
Ensembl chr  X:58,306,776...58,471,417 		JBrowse link
G GFER growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:38,948,927...38,951,300
Ensembl chr 6:38,949,484...38,951,703 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOLA3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chr17:48,941,730...48,952,327
Ensembl chr17:48,941,387...48,989,852 		JBrowse link
G FDX1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 5:22,452,011...22,485,581
Ensembl chr 5:22,451,209...22,485,395 		JBrowse link
G FDX2 ferredoxin 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr20:50,798,250...50,802,477 JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chr 9:5,567,411...5,577,427
Ensembl chr 9:5,567,328...5,577,277 		JBrowse link
G GLRX5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 8:64,383,203...64,392,886
Ensembl chr 8:64,383,227...64,383,841 		JBrowse link
G HSCB HscB mitochondrial iron-sulfur cluster cochaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chr26:22,103,803...22,120,200
Ensembl chr26:22,103,845...22,120,198 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chr11:26,122,917...26,142,458
Ensembl chr11:26,121,499...26,142,434 		JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:799,540...804,191
Ensembl chr14:800,294...801,811 		JBrowse link
G ISCA2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 8:47,650,864...47,657,896
Ensembl chr 8:47,650,938...47,652,292 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chr26:18,300,800...18,307,668
Ensembl chr26:18,300,803...18,307,652 		JBrowse link
G LYRM4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chr35:5,229,851...5,373,965 JBrowse link
G NFS1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chr24:24,593,348...24,614,938
Ensembl chr24:24,594,264...24,614,902 		JBrowse link
G NFU1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chr10:68,134,865...68,161,841
Ensembl chr10:68,134,902...68,335,988 		JBrowse link
G NUBPL NUBP iron-sulfur cluster assembly factor, mitochondrial ISO RGD PMID:25245479 RGD:11554190 NCBI chr 8:10,796,462...11,026,804
Ensembl chr 8:10,796,459...11,090,920 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4046
    classic metabolic pathway 1010
      metabolic pathway of cofactors, vitamins, nutrients 238
        iron-sulfur cluster protein biogenesis pathway 25
          cytosolic iron-sulfur cluster protein assembly pathway 9
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 14
Path 2
Term Annotations click to browse term
  pathway 4046
    regulatory pathway 2499
      homeostasis pathway 1305
        inorganic chemical homeostasis pathway 291
          metal homeostasis pathway 199
            iron homeostasis pathway 61
              iron utilization pathway 36
                iron-sulfur cluster protein biogenesis pathway 25
                  cytosolic iron-sulfur cluster protein assembly pathway 9
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 14
paths to the root