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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.

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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ciao1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955470:3,822,606...3,828,563
Ensembl chrNW_004955470:3,822,582...3,828,563 		JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955450:11,306,099...11,327,688
Ensembl chrNW_004955450:11,306,099...11,331,758 		JBrowse link
G Ciao2b cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955433:23,435,373...23,437,383 JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955442:16,465,759...16,475,110
Ensembl chrNW_004955442:16,465,178...16,475,110 		JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955433:15,065,031...15,081,392
Ensembl chrNW_004955433:15,065,031...15,081,293 		JBrowse link
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955507:3,593,413...3,623,781
Ensembl chrNW_004955507:3,593,413...3,623,781 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955513:5,208,040...5,216,618
Ensembl chrNW_004955513:5,208,151...5,216,182 		JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955442:7,717,422...7,732,496
Ensembl chrNW_004955442:7,717,422...7,732,496 		JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004955442:15,482,916...15,486,830
Ensembl chrNW_004955442:15,483,549...15,486,741 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955562:1,079,884...1,220,806
Ensembl chrNW_004955562:1,077,198...1,221,061 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955442:15,280,753...15,283,405
Ensembl chrNW_004955442:15,281,419...15,283,266 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bola3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955424:11,583,508...11,590,626
Ensembl chrNW_004955424:11,583,370...11,590,947 		JBrowse link
G Fdx1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955412:12,280,900...12,312,930
Ensembl chrNW_004955412:12,286,408...12,316,707 		JBrowse link
G Fdx2 ferredoxin 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955495:1,590,493...1,594,760
Ensembl chrNW_004955495:1,590,493...1,594,760 		JBrowse link
G Fdxr ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955553:1,746,759...1,755,316
Ensembl chrNW_004955553:1,746,670...1,755,315 		JBrowse link
G Glrx5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955438:17,067,017...17,076,162
Ensembl chrNW_004955438:17,066,955...17,075,789 		JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster cochaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955455:3,005,617...3,013,393 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955418:1,915,985...1,931,017
Ensembl chrNW_004955418:1,915,985...1,931,017 		JBrowse link
G Iba57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955581:284,488...289,225
Ensembl chrNW_004955581:286,121...289,139 		JBrowse link
G Isca1 iron-sulfur cluster assembly 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955432:1,335,481...1,349,852
Ensembl chrNW_004955432:1,335,481...1,349,847 		JBrowse link
G Isca2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955523:1,008,246...1,010,030
Ensembl chrNW_004955523:1,008,246...1,010,041 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955455:9,833,924...9,840,547
Ensembl chrNW_004955455:9,833,924...9,841,619 		JBrowse link
G Lyrm4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955465:8,346,012...8,470,251 JBrowse link
G Nfs1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955422:25,759,988...25,785,560
Ensembl chrNW_004955422:25,760,099...25,785,108 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955424:15,648,213...15,671,383
Ensembl chrNW_004955424:15,647,623...15,674,573 		JBrowse link
G Nubpl NUBP iron-sulfur cluster assembly factor, mitochondrial ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004955409:28,873,609...29,073,196
Ensembl chrNW_004955409:28,872,189...29,073,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    classic metabolic pathway 967
      metabolic pathway of cofactors, vitamins, nutrients 226
        iron-sulfur cluster protein biogenesis pathway 26
          cytosolic iron-sulfur cluster protein assembly pathway 9
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 15
Path 2
Term Annotations click to browse term
  pathway 3924
    regulatory pathway 2432
      homeostasis pathway 1271
        inorganic chemical homeostasis pathway 289
          metal homeostasis pathway 197
            iron homeostasis pathway 61
              iron utilization pathway 37
                iron-sulfur cluster protein biogenesis pathway 26
                  cytosolic iron-sulfur cluster protein assembly pathway 9
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 15
paths to the root