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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.


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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CIAO1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr2A:103,041,509...103,049,469
Ensembl chr2A:97,188,949...97,194,576 		JBrowse link
G CIAO2A cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr15:43,025,577...43,047,013
Ensembl chr15:61,317,188...61,338,337 		JBrowse link
G CIAO2B cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr16:47,247,278...47,249,617
Ensembl chr16:66,349,377...66,351,733 		JBrowse link
G CIAO3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 Ensembl chr16:742,818...754,087 JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr16:37,701,773...37,723,556
Ensembl chr16:56,835,024...56,856,502 		JBrowse link
G MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr10:94,080,690...94,120,811
Ensembl chr10:97,574,257...97,614,146 		JBrowse link
G NDOR1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 9:108,265,305...108,278,923
Ensembl chr 9:137,233,940...137,247,716 		JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr16:9,681,800...9,708,673
Ensembl chr16:10,906,719...10,931,800 		JBrowse link
G NUBP2 NUBP iron-sulfur cluster assembly factor 2, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr16:405,264...411,626 JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chr  X:64,304,101...64,407,310
Ensembl chr  X:74,418,754...74,521,726 		JBrowse link
G GFER growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chr16:716,640...720,196
Ensembl chr16:2,073,064...2,076,592 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOLA3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chr2A:74,207,111...74,219,705
Ensembl chr2A:75,715,161...75,727,622 		JBrowse link
G FDX1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr11:105,311,613...105,345,414 JBrowse link
G FDX2 ferredoxin 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr19:9,860,316...9,866,442
Ensembl chr19:10,526,287...10,532,152 		JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chr17:68,808,123...68,818,642
Ensembl chr17:74,364,343...74,374,852 		JBrowse link
G GLRX5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:76,162,541...76,172,291 JBrowse link
G HSCB HscB mitochondrial iron-sulfur cluster cochaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chr22:9,811,294...9,826,245
Ensembl chr22:27,512,564...27,527,914 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 5:133,934,859...133,955,048
Ensembl chr 5:140,064,207...140,084,551 		JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 1:203,566,902...203,577,857 JBrowse link
G ISCA1 iron-sulfur cluster assembly 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 9:57,410,328...57,428,477
Ensembl chr 9:85,467,145...85,485,107 		JBrowse link
G ISCA2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:55,046,821...55,048,602
Ensembl chr14:73,894,694...73,896,444 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:106,132,987...106,140,879
Ensembl chr12:109,529,162...109,537,053 		JBrowse link
G LYRM4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:4,887,010...5,096,384
Ensembl chr 6:5,127,918...5,279,038 		JBrowse link
G NFS1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chr20:31,994,509...32,026,776 JBrowse link
G NFU1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chr2A:69,438,979...69,480,470
Ensembl chr2A:70,559,872...70,600,301 		JBrowse link
G NUBPL NUBP iron-sulfur cluster assembly factor, mitochondrial ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:12,338,341...12,628,346 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    classic metabolic pathway 1016
      metabolic pathway of cofactors, vitamins, nutrients 239
        iron-sulfur cluster protein biogenesis pathway 26
          cytosolic iron-sulfur cluster protein assembly pathway 9
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 15
Path 2
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      homeostasis pathway 1306
        inorganic chemical homeostasis pathway 292
          metal homeostasis pathway 200
            iron homeostasis pathway 62
              iron utilization pathway 37
                iron-sulfur cluster protein biogenesis pathway 26
                  cytosolic iron-sulfur cluster protein assembly pathway 9
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 15
paths to the root