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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:protease mediated signaling via protease-activated receptor 1
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Accession:PW:0002607 term browser browse the term
Definition:Protease-activated receptor 1 (PAR1/F2R) is primarily a target of coagulation factor 2, thrombin, but other proteases can prompt or disarm it. PAR1 signaling plays many roles in the immune, cardiovascular and nervous system.
Synonyms:related_synonym: protease mediated signaling via F2R;   protease mediated signaling via PAR1

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protease mediated signaling via protease-activated receptor 1 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin ISO RGD PMID:27126649 RGD:11352286 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor ISO RGD PMID:23809128 PMID:27126649 RGD:11352294, RGD:11352286 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa ISO RGD PMID:23809128 RGD:11352294 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Procr protein C receptor ISO RGD PMID:23809128 RGD:11352294 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
JBrowse link

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  pathway 6098
    signaling pathway 2648
      protease mediated signaling pathway 8
        protease mediated signaling via protease-activated receptor 1 4
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