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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:protease mediated signaling pathway
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Accession:PW:0002606 term browser browse the term
Definition:Proteases, the vitamin K-dependent coagulation proteases in particular, can activate a specific class of G protein-coupled receptors harboring an internally tethered ligand. The four protease-activated receptors (PARs) are involved in numerous physiologically relevant processes and can also play a role in disease-related aspects. PARs can be cleaved at different sites by different proteases to elicit distinct signaling responses, referred to as biased signaling.


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protease mediated signaling via protease-activated receptor 1 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II ISO RGD PMID:27126649 RGD:11352286 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor ISO RGD PMID:23809128 PMID:27126649 RGD:11352294, RGD:11352286 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa ISO RGD PMID:23809128 RGD:11352294 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Procr protein C receptor ISO RGD PMID:23809128 RGD:11352294 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903 		JBrowse link
protease mediated signaling via protease-activated receptor 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X ISO RGD PMID:27126649 RGD:11352286 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO RGD PMID:27126649 RGD:11352286 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
protease mediated signaling via protease-activated receptor 3 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II ISO RGD PMID:27126649 RGD:11352286 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 ISO RGD PMID:27126649 RGD:11352286 NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098 		JBrowse link
protease mediated signaling via protease-activated receptor 4 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II ISO RGD PMID:27126649 RGD:11352286 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 ISO RGD PMID:27126649 RGD:11352286 NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472 		JBrowse link
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