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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nicotinamide adenine dinucleotide metabolic pathway
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Accession:PW:0002580 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis and utilization of nicotinamide adenine dinucleotide (NAD). There are several routes leading to NAD biosynthesis from various sources. NAD, in addition to its well known role as a cofactor in redox reactions, also serves as a substrate for several classes of enzymes.
Synonyms:exact_synonym: NAD metabolic pathway
 related_synonym: SMP:00124;   SMP:00129
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nicotinamide adenine dinucleotide metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO SMPDB SMP:00124 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble ISO RGD PMID:18020963 PMID:16368075 RGD:5129954, RGD:11251688 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00129, RGD:5129954, RGD:11251688 NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00124, RGD:5129954, RGD:11251688 NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886 		JBrowse link
G Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00124, RGD:5129954, RGD:11251688 NCBI chr 2:57,127,690...57,260,731
Ensembl chr 2:57,127,647...57,260,731 		JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) ISO RGD PMID:18020963 PMID:16368075 RGD:5129954, RGD:11251688 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367 		JBrowse link
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00129, RGD:5129954, RGD:11251688 NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252 		JBrowse link
G Nadk NAD kinase ISO RGD PMID:25641397 RGD:11250407 NCBI chr 4:155,646,838...155,675,458
Ensembl chr 4:155,646,835...155,675,458 		JBrowse link
G Nadk2 NAD kinase 2, mitochondrial ISO RGD PMID:25641397 RGD:11250407 NCBI chr15:9,071,340...9,110,584
Ensembl chr15:9,071,340...9,110,979 		JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase ISO RGD PMID:20007326 RGD:11099972 NCBI chr13:119,472,063...119,545,793
Ensembl chr13:119,471,984...119,545,533
Ensembl chr13:119,471,984...119,545,533 		JBrowse link
G Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 ISO RGD PMID:18020963 PMID:16368075 RGD:5129954, RGD:11251688 NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248 		JBrowse link
G Slc22a13 solute carrier family 22 (organic cation transporter), member 13 ISO RGD PMID:25837229 RGD:11251687 NCBI chr 9:119,020,618...119,038,171
Ensembl chr 9:119,022,040...119,038,164 		JBrowse link
G Slc25a11 solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 ISO SMPDB SMP:00129 NCBI chr11:70,534,845...70,538,356
Ensembl chr11:70,535,022...70,538,305 		JBrowse link
G Slc25a12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 ISO SMPDB
RGD		 PMID:18020963 PMID:16368075 SMP:00129, RGD:5129954, RGD:11251688 NCBI chr 2:71,104,614...71,198,125
Ensembl chr 2:71,101,407...71,198,093 		JBrowse link
G Slc25a13 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 ISO RGD PMID:16368075 RGD:11251688 NCBI chr 6:6,041,218...6,217,304
Ensembl chr 6:6,041,218...6,217,173 		JBrowse link
G Slc36a4 solute carrier family 36 (proton/amino acid symporter), member 4 ISO RGD PMID:25837229 RGD:11251687 NCBI chr 9:15,621,034...15,653,684
Ensembl chr 9:15,621,034...15,654,657 		JBrowse link
G Slc5a8 solute carrier family 5 (iodide transporter), member 8 ISO RGD PMID:25837229 RGD:11251687 NCBI chr10:88,721,854...88,765,377
Ensembl chr10:88,721,854...88,765,377 		JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 ISO RGD PMID:25837229 RGD:11251687 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433 		JBrowse link
ADP-ribosylation pathway, cyclic ribosylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bst1 bone marrow stromal cell antigen 1 ISO RGD PMID:23576305 RGD:11250406 NCBI chr 5:43,976,235...44,000,810
Ensembl chr 5:43,976,227...44,001,328 		JBrowse link
G Cd38 CD38 antigen ISO RGD PMID:23576305 RGD:11250406 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717 		JBrowse link
ADP-ribosylation pathway, mono and poly-ribosylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor ISO RGD PMID:26091342 RGD:11100038 NCBI chr 6:87,605,407...87,649,244
Ensembl chr 6:87,605,406...87,649,175 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains ISO RGD PMID:26091342 RGD:11100038 NCBI chr 5:110,283,599...110,319,839
Ensembl chr 5:110,283,708...110,319,838 		JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr19:7,034,065...7,175,427
Ensembl chr19:7,034,178...7,175,422 		JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 2:140,237,223...142,234,886
Ensembl chr 2:140,237,229...142,234,886 		JBrowse link
G Oard1 O-acyl-ADP-ribose deacylase 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr17:48,717,028...48,724,298
Ensembl chr17:48,717,042...48,724,294 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase ISO RGD PMID:26091342 RGD:11100038 NCBI chr14:31,923,900...32,020,671
Ensembl chr14:31,923,906...32,019,507 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 ISO RGD PMID:26091342 RGD:11100038 NCBI chr15:76,117,195...76,127,640
Ensembl chr15:76,115,374...76,127,641 		JBrowse link
G Parp11 poly (ADP-ribose) polymerase family, member 11 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 6:127,423,803...127,491,200
Ensembl chr 6:127,423,803...127,471,224 		JBrowse link
G Parp12 poly (ADP-ribose) polymerase family, member 12 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 6:39,063,346...39,095,283
Ensembl chr 6:39,063,344...39,095,283 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 ISO RGD PMID:26091342 RGD:11100038 NCBI chr16:35,652,262...35,691,904
Ensembl chr16:35,653,244...35,691,914 		JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 9:65,121,918...65,146,502
Ensembl chr 9:65,102,635...65,146,506 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase family, member 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr14:51,045,347...51,058,758
Ensembl chr14:51,045,298...51,058,758 		JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 9:106,347,521...106,354,148
Ensembl chr 9:106,347,521...106,354,148 		JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 ISO RGD PMID:26091342 RGD:11100038 NCBI chr14:56,812,982...56,897,256
Ensembl chr14:56,813,076...56,897,251 		JBrowse link
G Parp6 poly (ADP-ribose) polymerase family, member 6 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 9:59,524,473...59,557,573
Ensembl chr 9:59,524,567...59,557,568 		JBrowse link
G Parp8 poly (ADP-ribose) polymerase family, member 8 ISO RGD PMID:26091342 RGD:11100038 NCBI chr13:116,987,378...117,162,549
Ensembl chr13:116,991,356...117,162,073 		JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 ISO RGD PMID:26091342 RGD:11100038 NCBI chr16:35,759,360...35,792,975
Ensembl chr16:35,758,840...35,792,975 		JBrowse link
G Rnf146 ring finger protein 146 ISO RGD PMID:26091342 RGD:11100038 NCBI chr10:29,220,172...29,238,438
Ensembl chr10:29,220,172...29,238,438 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase ISO RGD PMID:26091342 RGD:11100038 NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939 		JBrowse link
G Tnks tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase ISO RGD PMID:26091342 RGD:11100038 NCBI chr 8:35,296,333...35,432,844
Ensembl chr 8:35,293,614...35,432,844 		JBrowse link
G Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr19:36,811,583...36,870,877
Ensembl chr19:36,811,632...36,870,877 		JBrowse link
G Zc3hav1 zinc finger CCCH type, antiviral 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 6:38,282,221...38,332,859
Ensembl chr 6:38,282,221...38,331,538 		JBrowse link
de novo nicotinamide adenine dinucleotide biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nadsyn1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:143,349,326...143,376,598
Ensembl chr 7:143,349,321...143,376,586 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 4:149,552,026...149,569,667
Ensembl chr 4:149,552,029...149,569,659 		JBrowse link
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:152,830,532...152,995,012
Ensembl chr 1:152,830,744...152,995,007 		JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 9:98,169,487...98,302,586
Ensembl chr 9:98,169,488...98,302,491 		JBrowse link
G Qprt quinolinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:126,706,942...126,721,201
Ensembl chr 7:126,706,286...126,721,398 		JBrowse link
nicotinamide adenine dinucleotide biosynthesis, the salvage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nadsyn1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:143,349,326...143,376,598
Ensembl chr 7:143,349,321...143,376,586 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Naprt nicotinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr15:75,762,812...75,766,330
Ensembl chr15:75,762,805...75,766,330 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 4:149,552,026...149,569,667
Ensembl chr 4:149,552,029...149,569,659 		JBrowse link
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:152,830,532...152,995,012
Ensembl chr 1:152,830,744...152,995,007 		JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 9:98,169,487...98,302,586
Ensembl chr 9:98,169,488...98,302,491 		JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr19:18,609,380...18,629,555
Ensembl chr19:18,609,314...18,629,792 		JBrowse link
G Nmrk2 nicotinamide riboside kinase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr10:81,034,004...81,037,871
Ensembl chr10:81,034,004...81,037,885 		JBrowse link
Sirtuin mediated pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 ISO RGD PMID:26785480 RGD:11100032 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt2 sirtuin 2 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086 		JBrowse link
G Sirt3 sirtuin 3 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Sirt4 sirtuin 4 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 5:115,616,065...115,628,322
Ensembl chr 5:115,616,069...115,622,784 		JBrowse link
G Sirt5 sirtuin 5 ISO RGD PMID:26785480 RGD:11100032 NCBI chr13:43,518,849...43,549,073
Ensembl chr13:43,518,972...43,548,679 		JBrowse link
G Sirt6 sirtuin 6 ISO RGD PMID:26785480 RGD:11100032 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
G Sirt7 sirtuin 7 ISO RGD PMID:26785480 RGD:11100032 NCBI chr11:120,509,197...120,515,840
Ensembl chr11:120,509,198...120,516,066 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    classic metabolic pathway 1858
      metabolic pathway of cofactors, vitamins, nutrients 391
        nicotinamide adenine dinucleotide metabolic pathway 59
          NADPH regeneration pathway 0
          nicotinamide adenine dinucleotide biosynthetic pathway + 9
          nicotinamide adenine nucleotide utilization pathway + 32
paths to the root