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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:acid-base imbalance pathway
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Accession:PW:0002545 term browser browse the term
Definition:A disturbance that leads to changes in the body's normal balance of acids and bases resulting in deviation from the normal pH range. The imbalance is due to changes in renal or ventilation function. The changes can lead to an excess of acid, acidosis or acidaemia, or to an excess of vases, alkalosis or alkalemia.

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lactic acidosis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 ISO SMPDB SMP:00313 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
JBrowse link
G Aars2 alanyl-tRNA synthetase 2, mitochondrial ISO SMPDB SMP:00313 NCBI chr 9:15,484,639...15,496,116
Ensembl chr 9:15,297,531...15,496,090
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase ISO SMPDB SMP:00313 NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
JBrowse link
G Gpt glutamic--pyruvic transaminase ISO SMPDB SMP:00313 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Pc pyruvate carboxylase ISO SMPDB SMP:00313 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
succinyl-CoA:3-oxoacid transferase deficiency pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO SMPDB SMP:00569 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 ISO SMPDB SMP:00569 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase ISO SMPDB SMP:00569 NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 ISO SMPDB SMP:00569 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 ISO SMPDB SMP:00569 NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6100
    disease pathway 1955
      nutritional and metabolic disease pathway 708
        metabolic disease pathway 666
          acid-base imbalance pathway 10
            acidosis pathway + 10
            alkalosis pathway 0
paths to the root