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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:thyroglobulin processing pathway
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Accession:PW:0002520 term browser browse the term
Definition:Thyroglobulin, produced by the follicular cells of thyroid gland is used to produce the thyroid hormones via a number of steps. Thyroglobulin contains some 100-120 tyrosine residues, of which only a small fraction is used to produce thyroid hormones. Usually there are 5 to 6 molecules of either thyroxine (T4) and triiodothyronine (T3) derived from each molecule of thyroglobulin.

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thyroid hormone biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245 alpha chain ISO SMPDB SMP:00716 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain ISO SMPDB SMP:00716 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Duox1 dual oxidase 1 ISO SMPDB SMP:00716 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
JBrowse link
G Duox2 dual oxidase 2 ISO SMPDB SMP:00716 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
JBrowse link
G Nox3 NADPH oxidase 3 ISO SMPDB SMP:00716 NCBI chr 1:44,238,012...44,302,851
Ensembl chr 1:44,236,992...44,302,851
JBrowse link
G Nox4 NADPH oxidase 4 ISO SMPDB SMP:00716 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Slc26a4 solute carrier family 26 member 4 ISO SMPDB SMP:00716 NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703
JBrowse link
G Slc5a5 solute carrier family 5 member 5 ISO SMPDB SMP:00716 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Tg thyroglobulin ISO SMPDB SMP:00716 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Tpo thyroid peroxidase ISO SMPDB SMP:00716 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link

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  pathway 6091
    classic metabolic pathway 1854
      peptide and protein metabolic pathway 78
        peptide and protein hormone metabolic pathway 62
          thyroglobulin processing pathway 10
            thyroid hormone biosynthetic pathway 10
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