thyroglobulin processing pathway - Ontology Report - Rat Genome Database

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PATHWAY ONTOLOGY - ANNOTATIONS	{{ watchLinkText }}
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:	thyroglobulin processing pathway	go back to main search page
Accession:	PW:0002520	browse the term
Definition:	Thyroglobulin, produced by the follicular cells of thyroid gland is used to produce the thyroid hormones via a number of steps. Thyroglobulin contains some 100-120 tyrosine residues, of which only a small fraction is used to produce thyroid hormones. Usually there are 5 to 6 molecules of either thyroxine (T4) and triiodothyronine (T3) derived from each molecule of thyroglobulin.

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Genes (10)

thyroid hormone biosynthetic pathway

term browser

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome b-245 alpha chain

SMP:00716

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

SMP:00716

NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586

G

dual oxidase 1

SMP:00716

NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563

G

dual oxidase 2

SMP:00716

NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902

G

NADPH oxidase 3

SMP:00716

NCBI chr 1:44,238,012...44,302,851
Ensembl chr 1:44,236,992...44,302,851

G

NADPH oxidase 4

SMP:00716

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

solute carrier family 26 member 4

SMP:00716

NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703

G

solute carrier family 5 member 5

SMP:00716

NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697

G

thyroglobulin

SMP:00716

NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210

G

thyroid peroxidase

SMP:00716

NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199

Term paths to the root

Path 1
Term	Annotations
pathway	6100
classic metabolic pathway	1857
peptide and protein metabolic pathway	77
peptide and protein hormone metabolic pathway	62
thyroglobulin processing pathway	10
thyroid hormone biosynthetic pathway	10

paths to the root