Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:mexiletine pharmacodynamics pathway
go back to main search page
Accession:PW:0002339 term browser browse the term
Definition:The pathway of mexiletine-target interaction and of the biochemical or physiological responses to drug. The drug is a non-selective voltage-gated sodium channel blocker antiarrhythmic agent. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00329


GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
mexiletine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00329 NCBI chrNW_004624766:9,018,616...9,092,365
Ensembl chrNW_004624766:9,018,721...9,092,287
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00329 NCBI chrNW_004624752:16,792,202...16,926,552
Ensembl chrNW_004624752:16,792,165...16,927,293
JBrowse link
G Adrb1 adrenoceptor beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004624737:32,536,096...32,563,721
Ensembl chrNW_004624737:32,541,598...32,563,424
JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO SMPDB SMP:00329 NCBI chrNW_004624730:25,964,848...26,006,468
Ensembl chrNW_004624730:25,964,811...26,006,463
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00329 NCBI chrNW_004624772:12,099,523...12,127,437
Ensembl chrNW_004624772:12,099,435...12,127,737
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00329 NCBI chrNW_004624907:715,109...736,040
Ensembl chrNW_004624907:715,094...736,432
JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00329 NCBI chrNW_004624794:1,068,056...1,108,303 JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004624826:7,058,046...7,076,919
Ensembl chrNW_004624826:7,054,371...7,076,919
JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00329 NCBI chrNW_004624786:10,254,979...10,261,508
Ensembl chrNW_004624786:10,234,492...10,262,367
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00329 NCBI chrNW_004624730:18,510,840...18,544,528
Ensembl chrNW_004624730:18,510,844...18,544,836
JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00329 NCBI chrNW_004624931:234,184...255,154
Ensembl chrNW_004624931:234,103...255,189
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00329 NCBI chrNW_004624747:21,509,360...21,567,424
Ensembl chrNW_004624747:21,509,366...21,568,098
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00329 NCBI chrNW_004624735:10,201,030...10,927,349
Ensembl chrNW_004624735:10,201,526...10,432,896
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00329 NCBI chrNW_004624795:6,443,322...6,501,673
Ensembl chrNW_004624795:6,443,781...6,501,050
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00329 NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633
JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00329 NCBI chrNW_004624730:4,211,189...4,346,119
Ensembl chrNW_004624730:4,212,901...4,345,849
JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004624795:3,732,201...3,747,731
Ensembl chrNW_004624795:3,732,320...3,747,717
JBrowse link
G Calm1 calmodulin 1 ISO SMPDB SMP:00329 NCBI chrNW_004624734:12,030,264...12,041,682
Ensembl chrNW_004624734:12,030,001...12,041,772
JBrowse link
G Chrm2 cholinergic receptor muscarinic 2 ISO SMPDB SMP:00329 NCBI chrNW_004624765:17,211,162...17,342,505
Ensembl chrNW_004624765:17,333,678...17,340,421
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00329 NCBI chrNW_004624730:62,001,547...62,223,098
Ensembl chrNW_004624730:62,002,280...62,223,319
JBrowse link
G Fxyd2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00329 NCBI chrNW_004624784:13,198,308...13,209,780
Ensembl chrNW_004624784:13,200,018...13,206,131
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO SMPDB SMP:00329 NCBI chrNW_004624781:968,608...1,007,969
Ensembl chrNW_004624781:968,748...1,008,200
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 ISO SMPDB SMP:00329 NCBI chrNW_004624773:14,856,803...15,193,173
Ensembl chrNW_004624773:14,856,804...15,193,168
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO SMPDB SMP:00329 NCBI chrNW_004624860:2,042,325...2,045,953
Ensembl chrNW_004624860:2,039,771...2,045,867
JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00329 NCBI chrNW_004624772:7,482,462...7,694,316
Ensembl chrNW_004624772:7,484,632...7,693,329
JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00329 NCBI chrNW_004624745:22,624,414...22,631,625
Ensembl chrNW_004624745:22,624,765...22,631,609
JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00329 NCBI chrNW_004624745:22,552,809...22,553,321
Ensembl chrNW_004624745:22,525,037...22,556,000
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00329 NCBI chrNW_004624800:5,633,060...5,663,700
Ensembl chrNW_004624800:5,632,726...5,663,771
JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00329 NCBI chrNW_004624831:1,301,840...1,319,487
Ensembl chrNW_004624831:1,301,598...1,319,572
JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 ISO SMPDB SMP:00329 NCBI chrNW_004624766:9,012,166...9,015,269
Ensembl chrNW_004624766:9,013,225...9,014,397
JBrowse link
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 ISO SMPDB SMP:00329 NCBI chrNW_004624801:365,393...375,802
Ensembl chrNW_004624801:365,361...374,487
JBrowse link
G Kcnj3 potassium inwardly rectifying channel subfamily J member 3 ISO SMPDB SMP:00329 NCBI chrNW_004624732:11,128,474...11,278,528
Ensembl chrNW_004624732:11,132,024...11,278,026
JBrowse link
G Kcnj4 potassium inwardly rectifying channel subfamily J member 4 ISO SMPDB SMP:00329 NCBI chrNW_004624752:9,633,799...9,659,532
Ensembl chrNW_004624752:9,638,704...9,659,523
JBrowse link
G Kcnj5 potassium inwardly rectifying channel subfamily J member 5 ISO SMPDB SMP:00329 NCBI chrNW_004624812:3,213,619...3,243,514
Ensembl chrNW_004624812:3,213,774...3,244,012
JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 ISO SMPDB SMP:00329 NCBI chrNW_004624752:16,939,289...16,945,692
Ensembl chrNW_004624752:16,939,384...16,946,723
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00329 NCBI chrNW_004624775:16,494,054...16,538,089
Ensembl chrNW_004624775:16,493,949...16,538,025
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00329 NCBI chrNW_004624767:15,252,961...15,613,373
Ensembl chrNW_004624767:15,252,950...15,613,562
JBrowse link
G Mylk myosin light chain kinase ISO SMPDB SMP:00329 NCBI chrNW_004624912:1,952,053...2,213,196
Ensembl chrNW_004624912:1,953,838...2,172,561
JBrowse link
G Plcb1 phospholipase C beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004624741:9,030,817...9,859,597
Ensembl chrNW_004624741:9,031,204...9,856,556
JBrowse link
G Pln phospholamban ISO SMPDB SMP:00329 NCBI chrNW_004624798:11,522,245...11,528,741
Ensembl chrNW_004624798:11,522,269...11,528,775
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00329 NCBI chrNW_004624901:1,319,426...1,336,848
Ensembl chrNW_004624901:1,319,062...1,336,744
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00329 NCBI chrNW_004624870:3,552,608...3,575,461
Ensembl chrNW_004624870:3,552,745...3,574,880
JBrowse link
G Ryr2 ryanodine receptor 2 ISO SMPDB SMP:00329 NCBI chrNW_004624775:12,954,653...13,650,449
Ensembl chrNW_004624775:12,956,042...13,419,381
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00329 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211
JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO SMPDB SMP:00329 NCBI chrNW_004624738:21,648,277...22,026,385
Ensembl chrNW_004624738:21,651,489...21,939,927
JBrowse link
G Snta1 syntrophin alpha 1 ISO SMPDB SMP:00329 NCBI chrNW_004624842:5,805,409...5,834,553
Ensembl chrNW_004624842:5,805,342...5,834,022
JBrowse link
G Sntb1 syntrophin beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004624763:18,310,253...18,528,845
Ensembl chrNW_004624763:18,309,172...18,529,151
JBrowse link
G Sntb2 syntrophin beta 2 ISO SMPDB SMP:00329 NCBI chrNW_004624746:17,063,597...17,167,452
Ensembl chrNW_004624746:17,067,067...17,167,477
JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004624822:4,763,285...4,767,810
Ensembl chrNW_004624822:4,764,742...4,770,293
JBrowse link
G Tnni1 troponin I1, slow skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004624807:9,295,121...9,306,368
Ensembl chrNW_004624807:9,294,951...9,308,446
JBrowse link
G Tnni2 troponin I2, fast skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004624767:14,735,413...14,737,968
Ensembl chrNW_004624767:14,736,136...14,737,870
JBrowse link
G Tnni3 troponin I3, cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004624832:2,088,455...2,092,774
Ensembl chrNW_004624832:2,088,589...2,092,771
JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004624832:2,093,852...2,100,647
Ensembl chrNW_004624832:2,094,903...2,100,560
JBrowse link
G Tnnt2 troponin T2, cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004624807:9,332,202...9,348,610
Ensembl chrNW_004624807:9,336,904...9,348,396
JBrowse link
G Tnnt3 troponin T3, fast skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004624767:14,784,267...14,801,477
Ensembl chrNW_004624767:14,787,248...14,802,098
JBrowse link
G Tpm1 tropomyosin 1 ISO SMPDB SMP:00329 NCBI chrNW_004624781:9,414,500...9,442,357
Ensembl chrNW_004624781:9,414,500...9,442,544
JBrowse link
G Tpm2 tropomyosin 2 ISO SMPDB SMP:00329 NCBI chrNW_004624868:5,101,713...5,109,560
Ensembl chrNW_004624868:5,101,090...5,109,820
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3922
    drug pathway 349
      cardiovascular system drug pathway 160
        antiarrhythmic drug pathway 89
          mexiletine drug pathway 57
            mexiletine pharmacodynamics pathway 57
paths to the root