PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: mexiletine pharmacodynamics pathway
Accession: PW:0002339
browse the term
Definition: The pathway of mexiletine-target interaction and of the biochemical or physiological responses to drug. The drug is a non-selective voltage-gated sodium channel blocker antiarrhythmic agent. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00329
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Abcc8
ATP binding cassette subfamily C member 8
ISO
SMPDB
SMP:00329
NCBI chrNW_004624766:9,018,616...9,092,365
Ensembl chrNW_004624766:9,018,721...9,092,287
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Abcc9
ATP binding cassette subfamily C member 9
ISO
SMPDB
SMP:00329
NCBI chrNW_004624752:16,792,202...16,926,552
Ensembl chrNW_004624752:16,792,165...16,927,293
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Adrb1
adrenoceptor beta 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624737:32,536,096...32,563,721
Ensembl chrNW_004624737:32,541,598...32,563,424
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Agtr1
angiotensin II receptor type 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624730:25,964,848...26,006,468
Ensembl chrNW_004624730:25,964,811...26,006,463
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624772:12,099,523...12,127,437
Ensembl chrNW_004624772:12,099,435...12,127,737
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
ISO
SMPDB
SMP:00329
NCBI chrNW_004624907:715,109...736,040
Ensembl chrNW_004624907:715,094...736,432
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Atp1a4
ATPase Na+/K+ transporting subunit alpha 4
ISO
SMPDB
SMP:00329
NCBI chrNW_004624794:1,068,056...1,108,303
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624826:7,058,046...7,076,919
Ensembl chrNW_004624826:7,054,371...7,076,919
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Atp1b2
ATPase Na+/K+ transporting subunit beta 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624786:10,254,979...10,261,508
Ensembl chrNW_004624786:10,234,492...10,262,367
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Atp1b3
ATPase Na+/K+ transporting subunit beta 3
ISO
SMPDB
SMP:00329
NCBI chrNW_004624730:18,510,840...18,544,528
Ensembl chrNW_004624730:18,510,844...18,544,836
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Atp1b4
ATPase Na+/K+ transporting family member beta 4
ISO
SMPDB
SMP:00329
NCBI chrNW_004624931:234,184...255,154
Ensembl chrNW_004624931:234,103...255,189
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624747:21,509,360...21,567,424
Ensembl chrNW_004624747:21,509,366...21,568,098
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
ISO
SMPDB
SMP:00329
NCBI chrNW_004624735:10,201,030...10,927,349
Ensembl chrNW_004624735:10,201,526...10,432,896
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Cacna1g
calcium voltage-gated channel subunit alpha1 G
ISO
SMPDB
SMP:00329
NCBI chrNW_004624795:6,443,322...6,501,673
Ensembl chrNW_004624795:6,443,781...6,501,050
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Cacna1h
calcium voltage-gated channel subunit alpha1 H
ISO
SMPDB
SMP:00329
NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633
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Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624730:4,211,189...4,346,119
Ensembl chrNW_004624730:4,212,901...4,345,849
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Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624795:3,732,201...3,747,731
Ensembl chrNW_004624795:3,732,320...3,747,717
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Calm1
calmodulin 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624734:12,030,264...12,041,682
Ensembl chrNW_004624734:12,030,001...12,041,772
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Chrm2
cholinergic receptor muscarinic 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624765:17,211,162...17,342,505
Ensembl chrNW_004624765:17,333,678...17,340,421
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Dlg1
discs large MAGUK scaffold protein 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624730:62,001,547...62,223,098
Ensembl chrNW_004624730:62,002,280...62,223,319
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Fxyd2
FXYD domain containing ion transport regulator 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624784:13,198,308...13,209,780
Ensembl chrNW_004624784:13,200,018...13,206,131
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Hcn4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
ISO
SMPDB
SMP:00329
NCBI chrNW_004624781:968,608...1,007,969
Ensembl chrNW_004624781:968,748...1,008,200
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Itpr1
inositol 1,4,5-trisphosphate receptor type 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624773:14,856,803...15,193,173
Ensembl chrNW_004624773:14,856,804...15,193,168
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Kcna5
potassium voltage-gated channel subfamily A member 5
ISO
SMPDB
SMP:00329
NCBI chrNW_004624860:2,042,325...2,045,953
Ensembl chrNW_004624860:2,039,771...2,045,867
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Kcnd3
potassium voltage-gated channel subfamily D member 3
ISO
SMPDB
SMP:00329
NCBI chrNW_004624772:7,482,462...7,694,316
Ensembl chrNW_004624772:7,484,632...7,693,329
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Kcne1
potassium voltage-gated channel subfamily E regulatory subunit 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624745:22,624,414...22,631,625
Ensembl chrNW_004624745:22,624,765...22,631,609
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Kcne2
potassium voltage-gated channel subfamily E regulatory subunit 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624745:22,552,809...22,553,321
Ensembl chrNW_004624745:22,525,037...22,556,000
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Kcnh2
potassium voltage-gated channel subfamily H member 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624800:5,633,060...5,663,700
Ensembl chrNW_004624800:5,632,726...5,663,771
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Kcnip2
potassium voltage-gated channel interacting protein 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624831:1,301,840...1,319,487
Ensembl chrNW_004624831:1,301,598...1,319,572
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Kcnj11
potassium inwardly rectifying channel subfamily J member 11
ISO
SMPDB
SMP:00329
NCBI chrNW_004624766:9,012,166...9,015,269
Ensembl chrNW_004624766:9,013,225...9,014,397
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Kcnj2
potassium inwardly rectifying channel subfamily J member 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624801:365,393...375,802
Ensembl chrNW_004624801:365,361...374,487
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Kcnj3
potassium inwardly rectifying channel subfamily J member 3
ISO
SMPDB
SMP:00329
NCBI chrNW_004624732:11,128,474...11,278,528
Ensembl chrNW_004624732:11,132,024...11,278,026
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Kcnj4
potassium inwardly rectifying channel subfamily J member 4
ISO
SMPDB
SMP:00329
NCBI chrNW_004624752:9,633,799...9,659,532
Ensembl chrNW_004624752:9,638,704...9,659,523
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Kcnj5
potassium inwardly rectifying channel subfamily J member 5
ISO
SMPDB
SMP:00329
NCBI chrNW_004624812:3,213,619...3,243,514
Ensembl chrNW_004624812:3,213,774...3,244,012
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Kcnj8
potassium inwardly rectifying channel subfamily J member 8
ISO
SMPDB
SMP:00329
NCBI chrNW_004624752:16,939,289...16,945,692
Ensembl chrNW_004624752:16,939,384...16,946,723
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Kcnk1
potassium two pore domain channel subfamily K member 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624775:16,494,054...16,538,089
Ensembl chrNW_004624775:16,493,949...16,538,025
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Kcnq1
potassium voltage-gated channel subfamily Q member 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624767:15,252,961...15,613,373
Ensembl chrNW_004624767:15,252,950...15,613,562
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Mylk
myosin light chain kinase
ISO
SMPDB
SMP:00329
NCBI chrNW_004624912:1,952,053...2,213,196
Ensembl chrNW_004624912:1,953,838...2,172,561
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Plcb1
phospholipase C beta 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624741:9,030,817...9,859,597
Ensembl chrNW_004624741:9,031,204...9,856,556
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Pln
phospholamban
ISO
SMPDB
SMP:00329
NCBI chrNW_004624798:11,522,245...11,528,741
Ensembl chrNW_004624798:11,522,269...11,528,775
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
ISO
SMPDB
SMP:00329
NCBI chrNW_004624901:1,319,426...1,336,848
Ensembl chrNW_004624901:1,319,062...1,336,744
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Prkar1a
protein kinase cAMP-dependent type I regulatory subunit alpha
ISO
SMPDB
SMP:00329
NCBI chrNW_004624870:3,552,608...3,575,461
Ensembl chrNW_004624870:3,552,745...3,574,880
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Ryr2
ryanodine receptor 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624775:12,954,653...13,650,449
Ensembl chrNW_004624775:12,956,042...13,419,381
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Scn5a
sodium voltage-gated channel alpha subunit 5
ISO
SMPDB
SMP:00329
NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211
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Slc8a1
solute carrier family 8 member A1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624738:21,648,277...22,026,385
Ensembl chrNW_004624738:21,651,489...21,939,927
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Snta1
syntrophin alpha 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624842:5,805,409...5,834,553
Ensembl chrNW_004624842:5,805,342...5,834,022
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Sntb1
syntrophin beta 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624763:18,310,253...18,528,845
Ensembl chrNW_004624763:18,309,172...18,529,151
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Sntb2
syntrophin beta 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624746:17,063,597...17,167,452
Ensembl chrNW_004624746:17,067,067...17,167,477
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Tnnc1
troponin C1, slow skeletal and cardiac type
ISO
SMPDB
SMP:00329
NCBI chrNW_004624822:4,763,285...4,767,810
Ensembl chrNW_004624822:4,764,742...4,770,293
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Tnni1
troponin I1, slow skeletal type
ISO
SMPDB
SMP:00329
NCBI chrNW_004624807:9,295,121...9,306,368
Ensembl chrNW_004624807:9,294,951...9,308,446
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Tnni2
troponin I2, fast skeletal type
ISO
SMPDB
SMP:00329
NCBI chrNW_004624767:14,735,413...14,737,968
Ensembl chrNW_004624767:14,736,136...14,737,870
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Tnni3
troponin I3, cardiac type
ISO
SMPDB
SMP:00329
NCBI chrNW_004624832:2,088,455...2,092,774
Ensembl chrNW_004624832:2,088,589...2,092,771
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Tnnt1
troponin T1, slow skeletal type
ISO
SMPDB
SMP:00329
NCBI chrNW_004624832:2,093,852...2,100,647
Ensembl chrNW_004624832:2,094,903...2,100,560
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Tnnt2
troponin T2, cardiac type
ISO
SMPDB
SMP:00329
NCBI chrNW_004624807:9,332,202...9,348,610
Ensembl chrNW_004624807:9,336,904...9,348,396
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Tnnt3
troponin T3, fast skeletal type
ISO
SMPDB
SMP:00329
NCBI chrNW_004624767:14,784,267...14,801,477
Ensembl chrNW_004624767:14,787,248...14,802,098
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Tpm1
tropomyosin 1
ISO
SMPDB
SMP:00329
NCBI chrNW_004624781:9,414,500...9,442,357
Ensembl chrNW_004624781:9,414,500...9,442,544
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Tpm2
tropomyosin 2
ISO
SMPDB
SMP:00329
NCBI chrNW_004624868:5,101,713...5,109,560
Ensembl chrNW_004624868:5,101,090...5,109,820
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all