PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: levobunolol pharmacodynamics pathway
Accession: PW:0002309
browse the term
Definition: The pathway of levobunolol-target interaction and of the biochemical or physiological responses to drug. The drug is a non-selective antagonist of beta adrenergic used in the treatment of glaucoma. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00666
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Abcc8
ATP binding cassette subfamily C member 8
ISO
SMPDB
SMP:00666
NCBI chrNW_004936528:1,608,782...1,682,873
Ensembl chrNW_004936528:1,608,757...1,682,975
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Abcc9
ATP binding cassette subfamily C member 9
ISO
SMPDB
SMP:00666
NCBI chrNW_004936548:4,983,461...5,110,693
Ensembl chrNW_004936548:4,987,847...5,108,104
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Adrb1
adrenoceptor beta 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936486:4,400,467...4,401,588
Ensembl chrNW_004936486:4,399,915...4,403,149
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Agtr1
angiotensin II receptor type 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638
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Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936740:489,357...514,235
Ensembl chrNW_004936740:488,154...514,308
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
ISO
SMPDB
SMP:00666
NCBI chrNW_004936706:476,473...494,659
Ensembl chrNW_004936706:477,107...495,525
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936481:17,438,146...17,460,329
Ensembl chrNW_004936481:17,436,270...17,460,348
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Atp1b2
ATPase Na+/K+ transporting subunit beta 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936595:908,019...914,426
Ensembl chrNW_004936595:907,919...915,053
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Atp1b3
ATPase Na+/K+ transporting subunit beta 3
ISO
SMPDB
SMP:00666
NCBI chrNW_004936540:3,621,656...3,640,885
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Atp1b4
ATPase Na+/K+ transporting family member beta 4
ISO
SMPDB
SMP:00666
NCBI chrNW_004936479:9,648,315...9,666,782
Ensembl chrNW_004936479:9,650,598...9,666,782
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936558:3,300,941...3,357,595
Ensembl chrNW_004936558:3,300,941...3,357,941
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
ISO
SMPDB
SMP:00666
NCBI chrNW_004936606:2,168,104...2,867,560
Ensembl chrNW_004936606:2,168,625...2,865,758
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Cacna1g
calcium voltage-gated channel subunit alpha1 G
ISO
SMPDB
SMP:00666
NCBI chrNW_004936490:11,093,600...11,157,756
Ensembl chrNW_004936490:11,093,595...11,157,563
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Cacna1h
calcium voltage-gated channel subunit alpha1 H
ISO
SMPDB
SMP:00666
NCBI chrNW_004936694:2,702,224...2,724,574
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Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936529:1,889,811...2,023,710
Ensembl chrNW_004936529:1,889,846...2,023,715
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Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936490:14,448,305...14,468,785
Ensembl chrNW_004936490:14,448,258...14,468,785
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Calm1
calmodulin 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936488:17,580,425...17,588,480
Ensembl chrNW_004936488:17,580,454...17,588,507
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Chrm2
cholinergic receptor muscarinic 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936592:1,396,939...1,525,255
Ensembl chrNW_004936592:1,521,547...1,522,947
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Dlg1
discs large MAGUK scaffold protein 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936833:551,989...843,064
Ensembl chrNW_004936833:551,799...844,121
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Fxyd2
FXYD domain containing ion transport regulator 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936542:2,956,784...2,961,076
Ensembl chrNW_004936542:2,956,785...2,963,506
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Hcn4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
ISO
SMPDB
SMP:00666
NCBI chrNW_004936471:32,527,551...32,570,548
Ensembl chrNW_004936471:32,529,847...32,570,284
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Itpr1
inositol 1,4,5-trisphosphate receptor type 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936577:3,896,455...4,198,396
Ensembl chrNW_004936577:3,896,390...4,198,411
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Kcnd3
potassium voltage-gated channel subfamily D member 3
ISO
SMPDB
SMP:00666
NCBI chrNW_004936690:417,907...627,025
Ensembl chrNW_004936690:422,883...621,308
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Kcne1
potassium voltage-gated channel subfamily E regulatory subunit 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936500:7,998,464...8,007,848
Ensembl chrNW_004936500:8,007,291...8,007,680
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Kcne2
potassium voltage-gated channel subfamily E regulatory subunit 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936500:8,067,009...8,072,383
Ensembl chrNW_004936500:8,068,188...8,068,553
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Kcnh2
potassium voltage-gated channel subfamily H member 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936527:6,380,222...6,412,390
Ensembl chrNW_004936527:6,379,669...6,412,390
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Kcnip2
potassium voltage-gated channel interacting protein 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936600:3,940,806...3,974,455
Ensembl chrNW_004936600:3,940,813...3,961,803
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Kcnj11
potassium inwardly rectifying channel subfamily J member 11
ISO
SMPDB
SMP:00666
NCBI chrNW_004936528:1,685,015...1,688,220
Ensembl chrNW_004936528:1,685,924...1,687,096
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Kcnj2
potassium inwardly rectifying channel subfamily J member 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936655:3,447,026...3,459,569
Ensembl chrNW_004936655:3,447,321...3,458,312
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Kcnj3
potassium inwardly rectifying channel subfamily J member 3
ISO
SMPDB
SMP:00666
NCBI chrNW_004936469:23,163,057...23,304,178
Ensembl chrNW_004936469:23,165,707...23,302,830
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Kcnj4
potassium inwardly rectifying channel subfamily J member 4
ISO
SMPDB
SMP:00666
NCBI chrNW_004936492:2,865,803...2,867,657
Ensembl chrNW_004936492:2,865,879...2,867,201
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Kcnj5
potassium inwardly rectifying channel subfamily J member 5
ISO
SMPDB
SMP:00666
NCBI chrNW_004936572:3,344,942...3,373,690
Ensembl chrNW_004936572:3,344,937...3,373,747
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Kcnj8
potassium inwardly rectifying channel subfamily J member 8
ISO
SMPDB
SMP:00666
NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078
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Kcnk1
potassium two pore domain channel subfamily K member 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936484:18,186,184...18,221,304
Ensembl chrNW_004936484:18,186,144...18,220,938
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Kcnq1
potassium voltage-gated channel subfamily Q member 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936794:707,122...994,206
Ensembl chrNW_004936794:707,119...994,778
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LOC101966280
sodium/potassium-transporting ATPase subunit alpha-4
ISO
SMPDB
SMP:00666
NCBI chrNW_004936740:445,952...478,580
Ensembl chrNW_004936740:445,952...478,532
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Mylk
myosin light chain kinase
ISO
SMPDB
SMP:00666
NCBI chrNW_004936725:1,418,930...1,594,697
Ensembl chrNW_004936725:1,424,130...1,592,840
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Plcb1
phospholipase C beta 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936485:10,548,966...11,254,139
Ensembl chrNW_004936485:10,548,966...11,253,761
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Pln
phospholamban
ISO
SMPDB
SMP:00666
NCBI chrNW_004936658:1,443,626...1,453,770
Ensembl chrNW_004936658:1,443,795...1,453,839
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
ISO
SMPDB
SMP:00666
NCBI chrNW_004936659:2,750,015...2,765,914
Ensembl chrNW_004936659:2,750,537...2,765,753
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Prkar1a
protein kinase cAMP-dependent type I regulatory subunit alpha
ISO
SMPDB
SMP:00666
NCBI chrNW_004936541:7,845,876...7,863,677
Ensembl chrNW_004936541:7,845,676...7,863,709
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Ryr2
ryanodine receptor 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936484:15,402,488...15,825,410
Ensembl chrNW_004936484:15,403,819...15,824,441
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Scn5a
sodium voltage-gated channel alpha subunit 5
ISO
SMPDB
SMP:00666
NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994
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Slc8a1
solute carrier family 8 member A1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936508:10,894,918...11,256,084
Ensembl chrNW_004936508:10,968,656...11,253,070
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Snta1
syntrophin alpha 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936561:7,101,654...7,134,529
Ensembl chrNW_004936561:7,101,654...7,133,988
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Sntb1
syntrophin beta 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936470:26,074,175...26,301,076
Ensembl chrNW_004936470:26,073,520...26,303,113
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Sntb2
syntrophin beta 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936475:19,335,584...19,425,642
Ensembl chrNW_004936475:19,335,664...19,420,683
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Tnnc1
troponin C1, slow skeletal and cardiac type
ISO
SMPDB
SMP:00666
NCBI chrNW_004936473:3,290,961...3,293,920
Ensembl chrNW_004936473:3,290,913...3,294,132
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Tnnc2
troponin C2, fast skeletal type
ISO
SMPDB
SMP:00666
NCBI chrNW_004936514:7,196,576...7,199,603
Ensembl chrNW_004936514:7,196,536...7,199,649
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Tnni1
troponin I1, slow skeletal type
ISO
SMPDB
SMP:00666
NCBI chrNW_004936567:3,013,359...3,025,137
Ensembl chrNW_004936567:3,013,342...3,025,171
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Tnni2
troponin I2, fast skeletal type
ISO
SMPDB
SMP:00666
NCBI chrNW_004936816:738,754...741,328
Ensembl chrNW_004936816:740,187...741,210
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Tnni3
troponin I3, cardiac type
ISO
SMPDB
SMP:00666
NCBI chrNW_004936886:437,754...440,925
Ensembl chrNW_004936886:437,754...440,458
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Tnnt1
troponin T1, slow skeletal type
ISO
SMPDB
SMP:00666
NCBI chrNW_004936886:425,331...434,546
Ensembl chrNW_004936886:425,438...435,500
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Tnnt2
troponin T2, cardiac type
ISO
SMPDB
SMP:00666
NCBI chrNW_004936567:3,052,167...3,069,077
Ensembl chrNW_004936567:3,056,845...3,068,887
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Tnnt3
troponin T3, fast skeletal type
ISO
SMPDB
SMP:00666
NCBI chrNW_004936816:805,360...822,044
Ensembl chrNW_004936816:805,317...822,043
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Tpm1
tropomyosin 1
ISO
SMPDB
SMP:00666
NCBI chrNW_004936471:23,643,645...23,670,775
Ensembl chrNW_004936471:23,643,613...23,670,775
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Tpm2
tropomyosin 2
ISO
SMPDB
SMP:00666
NCBI chrNW_004936524:3,679,719...3,687,828
Ensembl chrNW_004936524:3,679,560...3,688,308
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all