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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:AICA-ribosuria pathway
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Accession:PW:0002294 term browser browse the term
Definition:A condition resulting from alterations in the de novo purine biosynthetic pathway and due to defects in the enzyme catalyzing the final steps.
Synonyms:exact_synonym: AICAR Transformylase Inosine Monophosphate Cyclohydrolase Deficiency Pathway;   AICAR Transformylase/IMP Cyclohydrloase Deficiency Pathway
 related_synonym: SMP:00168



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AICA-ribosuria pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO SMPDB SMP:00168 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,497...47,072,245
JBrowse link
G ADCY10 adenylate cyclase 10 ISO SMPDB SMP:00168 NCBI chr 4:83,103,768...83,205,015
Ensembl chr 4:83,098,290...83,205,454
JBrowse link
G ADSL adenylosuccinate lyase ISO SMPDB SMP:00168 NCBI chr 5:8,027,799...8,045,480
Ensembl chr 5:8,025,508...8,047,603
JBrowse link
G ADSS2 adenylosuccinate synthase 2 ISO SMPDB SMP:00168 NCBI chr10:17,220,081...17,259,141
Ensembl chr10:17,220,207...17,259,182
JBrowse link
G AK1 adenylate kinase 1 ISO SMPDB SMP:00168 NCBI chr 1:268,355,032...268,365,659
Ensembl chr 1:268,355,033...268,365,598
JBrowse link
G AMPD1 adenosine monophosphate deaminase 1 ISO SMPDB SMP:00168 NCBI chr 4:105,868,834...105,892,171
Ensembl chr 4:105,868,897...105,893,769
JBrowse link
G APRT adenine phosphoribosyltransferase ISO SMPDB SMP:00168 NCBI chr 6:890,272...893,278
Ensembl chr 6:890,831...893,276
JBrowse link
G ATAD1 ATPase family AAA domain containing 1 ISO SMPDB SMP:00168 NCBI chr14:99,802,939...99,885,562
Ensembl chr14:99,815,203...99,885,160
JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO SMPDB SMP:00168 NCBI chr15:117,617,584...117,649,063
Ensembl chr15:117,617,502...117,649,107
JBrowse link
G DGUOK deoxyguanosine kinase ISO SMPDB SMP:00168 NCBI chr 3:69,054,749...69,091,366
Ensembl chr 3:69,054,761...69,091,341
JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO SMPDB SMP:00168 NCBI chr 7:97,270,698...97,316,578
Ensembl chr 7:97,266,824...97,306,981
JBrowse link
G ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 ISO SMPDB SMP:00168
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO SMPDB SMP:00168 NCBI chr13:197,130,898...197,158,797
Ensembl chr13:197,130,904...197,161,891
JBrowse link
G GDA guanine deaminase ISO SMPDB SMP:00168 NCBI chr 1:225,425,389...225,589,835
Ensembl chr 1:225,403,138...225,589,827
JBrowse link
G GMPR guanosine monophosphate reductase ISO SMPDB SMP:00168 NCBI chr 7:12,254,393...12,298,802
Ensembl chr 7:12,254,388...12,299,531
JBrowse link
G GMPS guanine monophosphate synthase ISO SMPDB SMP:00168 NCBI chr13:95,742,342...95,820,903
Ensembl chr13:95,738,659...95,819,759
JBrowse link
G GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2 ISO SMPDB SMP:00168 NCBI chr 9:62,101,581...62,510,803
Ensembl chr 9:62,101,613...62,499,581
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 ISO SMPDB SMP:00168 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687
JBrowse link
G GUK1 guanylate kinase 1 ISO SMPDB SMP:00168 NCBI chr 2:51,247,665...51,257,481
Ensembl chr 2:51,241,952...51,257,485
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00168 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,204...110,357,894
JBrowse link
G IMPDH1 inosine monophosphate dehydrogenase 1 ISO SMPDB SMP:00168 NCBI chr18:19,979,983...19,996,432
Ensembl chr18:19,979,983...19,996,429
JBrowse link
G ITPA inosine triphosphatase ISO SMPDB SMP:00168 NCBI chr17:32,458,351...32,474,827
Ensembl chr17:32,455,459...32,474,784
JBrowse link
G NME6 NME/NM23 nucleoside diphosphate kinase 6 ISO SMPDB SMP:00168 NCBI chr13:31,048,367...31,053,285
Ensembl chr13:31,046,948...31,053,130
JBrowse link
G NT5C2 5'-nucleotidase, cytosolic II ISO SMPDB SMP:00168 NCBI chr14:114,062,451...114,167,460
Ensembl chr14:114,062,459...114,145,109
JBrowse link
G NUDT2 nudix hydrolase 2 ISO SMPDB SMP:00168 NCBI chr10:32,450,986...32,466,893
Ensembl chr10:32,451,064...32,466,839
JBrowse link
G NUDT5 nudix hydrolase 5 ISO SMPDB SMP:00168 NCBI chr10:59,765,444...59,787,773
Ensembl chr10:59,765,703...59,790,157
JBrowse link
G PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase ISO SMPDB SMP:00168 NCBI chr 8:55,700,700...55,722,982
Ensembl chr 8:55,700,956...55,722,979
JBrowse link
G PDE10A phosphodiesterase 10A ISO SMPDB SMP:00168 NCBI chr 1:3,120,418...3,394,236
Ensembl chr 1:2,829,411...3,392,651
JBrowse link
G PDE4D phosphodiesterase 4D ISO SMPDB SMP:00168 NCBI chr16:37,897,300...39,406,534
Ensembl chr16:37,897,302...39,306,364
JBrowse link
G PFAS phosphoribosylformylglycinamidine synthase ISO SMPDB SMP:00168 NCBI chr12:53,458,401...53,477,254 JBrowse link
G PNP purine nucleoside phosphorylase ISO SMPDB SMP:00168 NCBI chr 7:78,426,838...78,447,029
Ensembl chr 7:78,424,740...78,447,012
JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO SMPDB SMP:00168 NCBI chr 8:55,652,194...55,701,077
Ensembl chr 8:55,654,377...55,701,077
JBrowse link
G PRPS1L1 phosphoribosyl pyrophosphate synthetase 1 like 1 ISO SMPDB SMP:00168 NCBI chr 9:87,161,863...87,164,314
Ensembl chr 9:87,163,252...87,164,208
JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00168 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143
JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00168 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644
JBrowse link
G TXN thioredoxin ISO SMPDB SMP:00168 NCBI chr 1:251,264,180...251,278,000
Ensembl chr 1:251,263,175...251,277,988
JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB SMP:00168 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4047
    disease pathway 712
      nervous system disease pathway 445
        sensory system disease pathway 88
          AICA-ribosuria pathway 37
Path 2
Term Annotations click to browse term
  pathway 4047
    disease pathway 712
      nutritional and metabolic disease pathway 574
        metabolic disease pathway 535
          inborn error of metabolism pathway 518
            AICA-ribosuria pathway 37
paths to the root