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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:naloxone pharmacodynamics pathway
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Accession:PW:0002284 term browser browse the term
Definition:The pathway of naloxone-target interaction and of the biochemical or physiological responses to drug. Naloxone is a mu-opioid receptor competitive antagonist. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00688

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naloxone pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO SMPDB SMP:00688 NCBI chrNW_004936757:149,366...237,710
Ensembl chrNW_004936757:150,496...237,710 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00688 NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00688 NCBI chrNW_004936740:489,357...514,235
Ensembl chrNW_004936740:488,154...514,308 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00688 NCBI chrNW_004936706:476,473...494,659
Ensembl chrNW_004936706:477,107...495,525 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00688 NCBI chrNW_004936481:17,438,146...17,460,329
Ensembl chrNW_004936481:17,436,270...17,460,348 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00688 NCBI chrNW_004936595:908,019...914,426
Ensembl chrNW_004936595:907,919...915,053 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00688 NCBI chrNW_004936540:3,621,656...3,640,885 JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00688 NCBI chrNW_004936479:9,648,315...9,666,782
Ensembl chrNW_004936479:9,650,598...9,666,782 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00688 NCBI chrNW_004936529:1,889,811...2,023,710
Ensembl chrNW_004936529:1,889,846...2,023,715 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00688 NCBI chrNW_004936490:14,448,305...14,468,785
Ensembl chrNW_004936490:14,448,258...14,468,785 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO SMPDB SMP:00688 NCBI chrNW_004936514:10,680,893...10,695,859
Ensembl chrNW_004936514:10,680,859...10,695,865 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO SMPDB SMP:00688 NCBI chrNW_004936580:4,165,255...4,179,285
Ensembl chrNW_004936580:4,166,619...4,186,443 		JBrowse link
G Drd1 dopamine receptor D1 ISO SMPDB SMP:00688 NCBI chrNW_004936609:790,647...795,187
Ensembl chrNW_004936609:792,276...793,613 		JBrowse link
G Fxyd2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00688 NCBI chrNW_004936542:2,956,784...2,961,076
Ensembl chrNW_004936542:2,956,785...2,963,506 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO SMPDB SMP:00688 NCBI chrNW_004936669:814,330...838,881
Ensembl chrNW_004936669:814,330...839,208 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO SMPDB SMP:00688 NCBI chrNW_004936530:8,286,101...8,612,183
Ensembl chrNW_004936530:8,287,574...8,608,343 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO SMPDB SMP:00688 NCBI chrNW_004936524:9,720,777...9,884,984
Ensembl chrNW_004936524:9,720,767...9,885,120 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO SMPDB SMP:00688 NCBI chrNW_004936480:5,042,531...5,047,157
Ensembl chrNW_004936480:5,043,204...5,044,472 		JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 ISO SMPDB SMP:00688 NCBI chrNW_004936605:4,370,222...4,828,972
Ensembl chrNW_004936605:4,372,671...4,825,423 		JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00688 NCBI chrNW_004936600:3,940,806...3,974,455
Ensembl chrNW_004936600:3,940,813...3,961,803 		JBrowse link
G LOC101960999 voltage-dependent P/Q-type calcium channel subunit alpha-1A ISO SMPDB SMP:00688 NCBI chrNW_004936659:2,201,606...2,269,625
Ensembl chrNW_004936659:2,192,610...2,392,638 		JBrowse link
G LOC101966280 sodium/potassium-transporting ATPase subunit alpha-4 ISO SMPDB SMP:00688 NCBI chrNW_004936740:445,952...478,580
Ensembl chrNW_004936740:445,952...478,532 		JBrowse link
G Oprm1 opioid receptor mu 1 ISO SMPDB SMP:00688 NCBI chrNW_004936489:6,506,207...6,567,136
Ensembl chrNW_004936489:6,506,207...6,548,946 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO SMPDB SMP:00688 NCBI chrNW_004936485:2,611,313...2,866,260
Ensembl chrNW_004936485:2,608,353...2,866,294 		JBrowse link
G Pomc proopiomelanocortin ISO SMPDB SMP:00688 NCBI chrNW_004936493:7,060,747...7,065,276
Ensembl chrNW_004936493:7,061,587...7,065,109 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO SMPDB SMP:00688 NCBI chrNW_004936473:28,010,123...28,102,124
Ensembl chrNW_004936473:28,010,123...28,102,124 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 ISO SMPDB SMP:00688 NCBI chrNW_004936570:1,187,916...1,195,423
Ensembl chrNW_004936570:1,186,711...1,195,388 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 ISO SMPDB SMP:00688 NCBI chrNW_004936475:7,937,920...7,973,563
Ensembl chrNW_004936475:7,938,519...7,973,538 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO SMPDB SMP:00688 NCBI chrNW_004936815:359,775...400,690
Ensembl chrNW_004936815:359,775...400,690 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO SMPDB SMP:00688 NCBI chrNW_004936538:6,205,268...6,239,062
Ensembl chrNW_004936538:6,205,251...6,239,083 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3945
    drug pathway 362
      various drug pathway 30
        naloxone drug pathway 30
          naloxone pharmacodynamics pathway 30
paths to the root