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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:various drug pathway
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Accession:PW:0002281 term browser browse the term
Definition:One of the subgroups of the Therapeutic Chemical Classification System developed by WHO for grouping drugs acting as antidotes, chelators, detoxifying agents, and others. The pharmacokinetics and pharmacodynamics of such agents. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.



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naloxone pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenergic receptor, alpha 1a ISO SMPDB SMP:00688 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide ISO SMPDB SMP:00688 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide ISO SMPDB SMP:00688 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide ISO SMPDB SMP:00688 NCBI chr 7:24,677,592...24,705,338
Ensembl chr 7:24,677,592...24,705,383
JBrowse link
G Atp1a4 ATPase, Na+/K+ transporting, alpha 4 polypeptide ISO SMPDB SMP:00688 NCBI chr 1:172,051,075...172,085,991
Ensembl chr 1:172,051,080...172,085,981
JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide ISO SMPDB SMP:00688 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924
JBrowse link
G Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide ISO SMPDB SMP:00688 NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768
JBrowse link
G Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide ISO SMPDB SMP:00688 NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495
JBrowse link
G Atp1b4 ATPase Na+/K+ transporting, beta 4 polypeptide ISO SMPDB SMP:00688 NCBI chr  X:37,404,999...37,425,661
Ensembl chr  X:37,405,061...37,425,646
JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit ISO SMPDB SMP:00688 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875
JBrowse link
G Cacna2d2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 ISO SMPDB SMP:00688 NCBI chr 9:107,276,948...107,406,545
Ensembl chr 9:107,276,811...107,406,542
JBrowse link
G Cacnb1 calcium channel, voltage-dependent, beta 1 subunit ISO SMPDB SMP:00688 NCBI chr11:97,892,339...97,913,860
Ensembl chr11:97,892,334...97,913,860
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 ISO SMPDB SMP:00688 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO SMPDB SMP:00688 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
JBrowse link
G Drd1 dopamine receptor D1 ISO SMPDB SMP:00688 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 ISO SMPDB SMP:00688 NCBI chr 9:45,311,007...45,321,576
Ensembl chr 9:45,310,967...45,321,576
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO SMPDB SMP:00688 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) ISO SMPDB SMP:00688 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
JBrowse link
G Grin3a glutamate receptor ionotropic, NMDA3A ISO SMPDB SMP:00688 NCBI chr 4:49,661,611...49,846,023
Ensembl chr 4:49,661,611...49,845,744
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A ISO SMPDB SMP:00688 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
JBrowse link
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 ISO SMPDB SMP:00688 NCBI chr 6:21,212,101...21,729,804
Ensembl chr 6:21,215,502...21,729,804
JBrowse link
G Kcnip2 Kv channel-interacting protein 2 ISO SMPDB SMP:00688 NCBI chr19:45,780,785...45,804,948
Ensembl chr19:45,780,278...45,804,500
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO SMPDB SMP:00688 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO SMPDB SMP:00688 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205
JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO SMPDB SMP:00688 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Scn10a sodium channel, voltage-gated, type X, alpha ISO SMPDB SMP:00688 NCBI chr 9:119,437,522...119,548,388
Ensembl chr 9:119,437,522...119,548,388
JBrowse link
G Scn1b sodium channel, voltage-gated, type I, beta ISO SMPDB SMP:00688 NCBI chr 7:30,815,949...30,826,436
Ensembl chr 7:30,815,949...30,826,428
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 ISO SMPDB SMP:00688 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO SMPDB SMP:00688 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 ISO SMPDB SMP:00688 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
JBrowse link

Term paths to the root
Path 1
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  pathway 6074
    drug pathway 402
      various drug pathway 30
        naloxone drug pathway + 30
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