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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:atenolol pharmacodynamics pathway
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Accession:PW:0002232 term browser browse the term
Definition:The pathway of atenolol-target interaction and of the biochemical or physiological responses to drug. The drug is a selective antagonist of beta adrenergic type 1 receptor. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00298

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atenolol pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00298 NCBI chr 1:47,494,861...47,578,818
Ensembl chr 1:47,494,959...47,578,882 		JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00298 NCBI chr11:21,658,804...21,797,851
Ensembl chr11:21,658,794...21,797,263 		JBrowse link
G ADRB1 adrenoceptor beta 1 ISO SMPDB SMP:00298 NCBI chr 9:106,920,520...106,923,424
Ensembl chr 9:106,920,610...106,922,058 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO SMPDB SMP:00298 NCBI chr15:41,957,826...42,002,776 JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00298 NCBI chr20:17,319,440...17,351,054
Ensembl chr20:17,315,117...17,351,054 		JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00298 NCBI chr20:3,801,044...3,828,680
Ensembl chr20:3,802,887...3,828,692 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00298 NCBI chr 6:36,166,586...36,195,343
Ensembl chr 6:36,166,262...36,195,363 		JBrowse link
G ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00298 NCBI chr20:3,759,509...3,794,106
Ensembl chr20:3,759,597...3,793,980 		JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00298 NCBI chr25:59,898,745...59,925,166
Ensembl chr25:59,895,341...59,925,522 		JBrowse link
G ATP1B2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00298 NCBI chr16:7,030,016...7,035,620
Ensembl chr16:7,030,055...7,037,754 		JBrowse link
G ATP1B3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00298 NCBI chr15:48,691,224...48,742,336
Ensembl chr15:48,690,667...48,742,385 		JBrowse link
G ATP1B4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00298
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00298 NCBI chr11:105,522,175...105,590,291
Ensembl chr11:105,522,157...105,590,958 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00298 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00298 NCBI chr16:42,710,640...42,776,736
Ensembl chr16:42,708,638...42,768,843 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00298 NCBI chr 5:1,039,709...1,106,212
Ensembl chr 5:1,078,973...1,106,507 		JBrowse link
G CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00298 NCBI chr22:11,751,026...11,891,407
Ensembl chr22:11,749,727...11,890,924 		JBrowse link
G CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00298 NCBI chr16:66,971,379...66,994,031
Ensembl chr16:66,971,459...66,996,095 		JBrowse link
G CALM1 calmodulin 1 ISO SMPDB SMP:00298 NCBI chr24:68,133,446...68,145,117
Ensembl chr24:68,133,428...68,145,180 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 ISO SMPDB SMP:00298 NCBI chr21:105,574,879...105,730,265
Ensembl chr21:105,726,175...105,727,575 		JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00298 NCBI chr15:89,937,900...90,214,976
Ensembl chr15:90,055,964...90,215,652 		JBrowse link
G FXYD2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00298 NCBI chr 1:109,187,301...109,199,729
Ensembl chr 1:109,186,886...109,198,267 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO SMPDB SMP:00298 NCBI chr26:10,107,342...10,158,885
Ensembl chr26:10,110,579...10,156,292 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO SMPDB SMP:00298 NCBI chr22:40,574,569...40,925,857
Ensembl chr22:40,574,374...40,926,842 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 ISO SMPDB SMP:00298 NCBI chr11:5,085,221...5,088,135
Ensembl chr11:5,085,518...5,087,335 		JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00298 NCBI chr20:21,618,365...21,833,443
Ensembl chr20:21,625,147...21,833,186 		JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00298 NCBI chr 2:78,500,755...78,557,275
Ensembl chr 2:78,503,317...78,503,757 		JBrowse link
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00298 NCBI chr 2:57,833,459...57,841,052
Ensembl chr 2:57,833,629...57,834,000 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00298 NCBI chr21:119,123,601...119,156,985
Ensembl chr21:119,124,007...119,156,794 		JBrowse link
G KCNIP2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00298 NCBI chr 9:94,854,024...94,873,655
Ensembl chr 9:94,855,403...94,873,312 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 ISO SMPDB SMP:00298 NCBI chr 1:47,582,519...47,586,466
Ensembl chr 1:47,583,629...47,584,801 		JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 ISO SMPDB SMP:00298 NCBI chr16:51,448,821...51,461,801
Ensembl chr16:51,452,567...51,453,850 		JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 ISO SMPDB SMP:00298 NCBI chr10:40,096,042...40,258,641
Ensembl chr10:40,096,527...40,255,646 		JBrowse link
G KCNJ4 potassium inwardly rectifying channel subfamily J member 4 ISO SMPDB SMP:00298 NCBI chr19:21,085,857...21,114,961
Ensembl chr19:21,086,322...21,087,659 		JBrowse link
G KCNJ5 potassium inwardly rectifying channel subfamily J member 5 ISO SMPDB SMP:00298 NCBI chr 1:120,025,238...120,098,006
Ensembl chr 1:120,025,300...120,057,023 		JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 ISO SMPDB SMP:00298 NCBI chr11:21,624,963...21,634,940
Ensembl chr11:21,624,970...21,634,042 		JBrowse link
G KCNK1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00298 NCBI chr25:70,820,089...70,873,654
Ensembl chr25:70,819,706...70,873,961 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00298 NCBI chr 1:2,261,448...2,661,840
Ensembl chr 1:2,261,845...2,661,863 		JBrowse link
G LOC103235292 troponin I, cardiac muscle ISO SMPDB SMP:00298 NCBI chr 6:47,746,293...47,752,118
Ensembl chr 6:47,745,386...47,752,204 		JBrowse link
G MYLK myosin light chain kinase ISO SMPDB SMP:00298 NCBI chr22:57,032,264...57,259,253
Ensembl chr22:57,065,331...57,257,464 		JBrowse link
G PLCB1 phospholipase C beta 1 ISO SMPDB SMP:00298 NCBI chr 2:29,242,601...29,994,238
Ensembl chr 2:29,242,425...29,496,793 		JBrowse link
G PLN phospholamban ISO SMPDB SMP:00298 NCBI chr13:55,316,962...55,332,502
Ensembl chr13:55,318,326...55,318,481 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00298 NCBI chr 6:12,743,752...12,759,155 JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00298 NCBI chr16:53,021,666...53,042,594
Ensembl chr16:53,023,963...53,042,493 		JBrowse link
G RYR2 ryanodine receptor 2 ISO SMPDB SMP:00298 NCBI chr25:74,169,024...74,951,371
Ensembl chr25:74,389,122...74,953,451 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00298 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO SMPDB SMP:00298 NCBI chr14:66,813,523...67,210,261 JBrowse link
G SNTA1 syntrophin alpha 1 ISO SMPDB SMP:00298 NCBI chr 2:37,703,002...37,737,529
Ensembl chr 2:37,702,971...37,737,423 		JBrowse link
G SNTB1 syntrophin beta 1 ISO SMPDB SMP:00298 NCBI chr 8:115,117,224...115,391,475
Ensembl chr 8:115,117,756...115,391,537 		JBrowse link
G SNTB2 syntrophin beta 2 ISO SMPDB SMP:00298 NCBI chr 5:58,096,883...58,220,668 JBrowse link
G TNNC1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00298 NCBI chr22:13,816,603...13,819,572
Ensembl chr22:13,816,222...13,819,518 		JBrowse link
G TNNC2 troponin C2, fast skeletal type ISO SMPDB SMP:00298 NCBI chr 2:18,051,708...18,063,108
Ensembl chr 2:18,061,492...18,062,971 		JBrowse link
G TNNI1 troponin I1, slow skeletal type ISO SMPDB SMP:00298 NCBI chr25:27,989,743...28,009,234
Ensembl chr25:27,997,709...28,002,646 		JBrowse link
G TNNI2 troponin I2, fast skeletal type ISO SMPDB SMP:00298 NCBI chr 1:1,657,631...1,661,575 JBrowse link
G TNNT1 troponin T1, slow skeletal type ISO SMPDB SMP:00298 NCBI chr 6:47,726,049...47,743,465
Ensembl chr 6:47,726,002...47,743,404 		JBrowse link
G TNNT2 troponin T2, cardiac type ISO SMPDB SMP:00298 NCBI chr25:28,035,563...28,054,322
Ensembl chr25:28,040,087...28,054,120 		JBrowse link
G TNNT3 troponin T3, fast skeletal type ISO SMPDB SMP:00298 NCBI chr 1:1,718,729...1,738,271
Ensembl chr 1:1,718,523...1,738,477 		JBrowse link
G TPM1 tropomyosin 1 ISO SMPDB SMP:00298 NCBI chr26:20,458,287...20,487,387
Ensembl chr26:20,466,037...20,487,135 		JBrowse link
G TPM2 tropomyosin 2 ISO SMPDB SMP:00298 NCBI chr12:44,912,250...44,920,615
Ensembl chr12:44,912,223...44,919,456 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4034
    drug pathway 383
      cardiovascular system drug pathway 178
        adrenergic beta receptor antagonist drug pathway 60
          adrenergic beta receptor selective antagonist drug pathway 59
            atenolol drug pathway 59
              atenolol pharmacodynamics pathway 59
paths to the root