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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:thrombolytic drug pathway
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Accession:PW:0002152 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of drugs that can dissolve blood clots. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.



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alteplase pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO SMPDB SMP:00280 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00280 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00280 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437
JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00280 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G F13a1 coagulation factor XIII A1 chain ISO SMPDB SMP:00280 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
JBrowse link
G F13b coagulation factor XIII B chain ISO SMPDB SMP:00280 NCBI chr13:51,130,908...51,156,383
Ensembl chr13:51,130,920...51,156,381
JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00280 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00280 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00280 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00280 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00280 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00280 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Fga fibrinogen alpha chain ISO SMPDB SMP:00280 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain ISO SMPDB SMP:00280 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain ISO SMPDB SMP:00280 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Ggcx gamma-glutamyl carboxylase ISO SMPDB SMP:00280 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
JBrowse link
G Klkb1 kallikrein B1 ISO SMPDB SMP:00280 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
G Plat plasminogen activator, tissue type ISO SMPDB SMP:00280 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plg plasminogen ISO SMPDB SMP:00280 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 ISO SMPDB SMP:00280 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
anistreplase pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO SMPDB SMP:00281 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00281 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00281 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437
JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00281 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G F13a1 coagulation factor XIII A1 chain ISO SMPDB SMP:00281 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
JBrowse link
G F13b coagulation factor XIII B chain ISO SMPDB SMP:00281 NCBI chr13:51,130,908...51,156,383
Ensembl chr13:51,130,920...51,156,381
JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00281 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00281 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00281 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00281 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00281 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00281 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Fga fibrinogen alpha chain ISO SMPDB SMP:00281 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain ISO SMPDB SMP:00281 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain ISO SMPDB SMP:00281 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Ggcx gamma-glutamyl carboxylase ISO SMPDB SMP:00281 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
JBrowse link
G Klkb1 kallikrein B1 ISO SMPDB SMP:00281 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
G Plat plasminogen activator, tissue type ISO SMPDB SMP:00281 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plg plasminogen ISO SMPDB SMP:00281 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 ISO SMPDB SMP:00281 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
reteplase pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO SMPDB SMP:00285 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00285 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00285 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437
JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00285 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G F13a1 coagulation factor XIII A1 chain ISO SMPDB SMP:00285 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
JBrowse link
G F13b coagulation factor XIII B chain ISO SMPDB SMP:00285 NCBI chr13:51,130,908...51,156,383
Ensembl chr13:51,130,920...51,156,381
JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00285 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00285 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00285 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00285 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00285 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00285 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Fga fibrinogen alpha chain ISO SMPDB SMP:00285 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain ISO SMPDB SMP:00285 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain ISO SMPDB SMP:00285 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Ggcx gamma-glutamyl carboxylase ISO SMPDB SMP:00285 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
JBrowse link
G Klkb1 kallikrein B1 ISO SMPDB SMP:00285 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
G Plat plasminogen activator, tissue type ISO SMPDB SMP:00285 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plg plasminogen ISO SMPDB SMP:00285 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 ISO SMPDB SMP:00285 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    drug pathway 397
      blood and blood forming organs drug pathway 62
        antithrombotic drug pathway 62
          thrombolytic drug pathway 20
            alteplase drug pathway + 20
            anistreplase drug pathway + 20
            reteplase drug pathway + 20
paths to the root