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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:isradipine pharmacodynamics pathway
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Accession:PW:0001974 term browser browse the term
Definition:The pathway of isradipine-target interaction and of the biochemical or physiological responses to drug. The drug is a calcium channel blocker, particularly the L-type channel, used for the treatment of high blood pressure. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00378

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isradipine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00378 NCBI chrNW_004936528:1,608,782...1,682,873
Ensembl chrNW_004936528:1,608,757...1,682,975 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00378 NCBI chrNW_004936548:4,983,461...5,110,693
Ensembl chrNW_004936548:4,987,847...5,108,104 		JBrowse link
G Adrb1 adrenoceptor beta 1 ISO SMPDB SMP:00378 NCBI chrNW_004936486:4,400,467...4,401,588
Ensembl chrNW_004936486:4,399,915...4,403,149 		JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO SMPDB SMP:00378 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00378 NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00378 NCBI chrNW_004936740:489,357...514,235
Ensembl chrNW_004936740:488,154...514,308 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00378 NCBI chrNW_004936706:476,473...494,659
Ensembl chrNW_004936706:477,107...495,525 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00378 NCBI chrNW_004936481:17,438,146...17,460,329
Ensembl chrNW_004936481:17,436,270...17,460,348 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00378 NCBI chrNW_004936595:908,019...914,426
Ensembl chrNW_004936595:907,919...915,053 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00378 NCBI chrNW_004936540:3,621,656...3,640,885 JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00378 NCBI chrNW_004936479:9,648,315...9,666,782
Ensembl chrNW_004936479:9,650,598...9,666,782 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00378 NCBI chrNW_004936558:3,300,941...3,357,595
Ensembl chrNW_004936558:3,300,941...3,357,941 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00378 NCBI chrNW_004936606:2,168,104...2,867,560
Ensembl chrNW_004936606:2,168,625...2,865,758 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00378 NCBI chrNW_004936490:11,093,600...11,157,756
Ensembl chrNW_004936490:11,093,595...11,157,563 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00378 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00378 NCBI chrNW_004936529:1,889,811...2,023,710
Ensembl chrNW_004936529:1,889,846...2,023,715 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00378 NCBI chrNW_004936490:14,448,305...14,468,785
Ensembl chrNW_004936490:14,448,258...14,468,785 		JBrowse link
G Calm1 calmodulin 1 ISO SMPDB SMP:00378 NCBI chrNW_004936488:17,580,425...17,588,480
Ensembl chrNW_004936488:17,580,454...17,588,507 		JBrowse link
G Chrm2 cholinergic receptor muscarinic 2 ISO SMPDB SMP:00378 NCBI chrNW_004936592:1,396,939...1,525,255
Ensembl chrNW_004936592:1,521,547...1,522,947 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00378 NCBI chrNW_004936833:551,989...843,064
Ensembl chrNW_004936833:551,799...844,121 		JBrowse link
G Fxyd2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00378 NCBI chrNW_004936542:2,956,784...2,961,076
Ensembl chrNW_004936542:2,956,785...2,963,506 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO SMPDB SMP:00378 NCBI chrNW_004936471:32,527,551...32,570,548
Ensembl chrNW_004936471:32,529,847...32,570,284 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 ISO SMPDB SMP:00378 NCBI chrNW_004936577:3,896,455...4,198,396
Ensembl chrNW_004936577:3,896,390...4,198,411 		JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00378 NCBI chrNW_004936690:417,907...627,025
Ensembl chrNW_004936690:422,883...621,308 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00378 NCBI chrNW_004936500:7,998,464...8,007,848
Ensembl chrNW_004936500:8,007,291...8,007,680 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00378 NCBI chrNW_004936500:8,067,009...8,072,383
Ensembl chrNW_004936500:8,068,188...8,068,553 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00378 NCBI chrNW_004936527:6,380,222...6,412,390
Ensembl chrNW_004936527:6,379,669...6,412,390 		JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00378 NCBI chrNW_004936600:3,940,806...3,974,455
Ensembl chrNW_004936600:3,940,813...3,961,803 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 ISO SMPDB SMP:00378 NCBI chrNW_004936528:1,685,015...1,688,220
Ensembl chrNW_004936528:1,685,924...1,687,096 		JBrowse link
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 ISO SMPDB SMP:00378 NCBI chrNW_004936655:3,447,026...3,459,569
Ensembl chrNW_004936655:3,447,321...3,458,312 		JBrowse link
G Kcnj3 potassium inwardly rectifying channel subfamily J member 3 ISO SMPDB SMP:00378 NCBI chrNW_004936469:23,163,057...23,304,178
Ensembl chrNW_004936469:23,165,707...23,302,830 		JBrowse link
G Kcnj4 potassium inwardly rectifying channel subfamily J member 4 ISO SMPDB SMP:00378 NCBI chrNW_004936492:2,865,803...2,867,657
Ensembl chrNW_004936492:2,865,879...2,867,201 		JBrowse link
G Kcnj5 potassium inwardly rectifying channel subfamily J member 5 ISO SMPDB SMP:00378 NCBI chrNW_004936572:3,344,942...3,373,690
Ensembl chrNW_004936572:3,344,937...3,373,747 		JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 ISO SMPDB SMP:00378 NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078 		JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00378 NCBI chrNW_004936484:18,186,184...18,221,304
Ensembl chrNW_004936484:18,186,144...18,220,938 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00378 NCBI chrNW_004936794:707,122...994,206
Ensembl chrNW_004936794:707,119...994,778 		JBrowse link
G LOC101966280 sodium/potassium-transporting ATPase subunit alpha-4 ISO SMPDB SMP:00378 NCBI chrNW_004936740:445,952...478,580
Ensembl chrNW_004936740:445,952...478,532 		JBrowse link
G Mylk myosin light chain kinase ISO SMPDB SMP:00378 NCBI chrNW_004936725:1,418,930...1,594,697
Ensembl chrNW_004936725:1,424,130...1,592,840 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO SMPDB SMP:00378 NCBI chrNW_004936485:10,548,966...11,254,139
Ensembl chrNW_004936485:10,548,966...11,253,761 		JBrowse link
G Pln phospholamban ISO SMPDB SMP:00378 NCBI chrNW_004936658:1,443,626...1,453,770
Ensembl chrNW_004936658:1,443,795...1,453,839 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00378 NCBI chrNW_004936659:2,750,015...2,765,914
Ensembl chrNW_004936659:2,750,537...2,765,753 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00378 NCBI chrNW_004936541:7,845,876...7,863,677
Ensembl chrNW_004936541:7,845,676...7,863,709 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO SMPDB SMP:00378 NCBI chrNW_004936484:15,402,488...15,825,410
Ensembl chrNW_004936484:15,403,819...15,824,441 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00378 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO SMPDB SMP:00378 NCBI chrNW_004936508:10,894,918...11,256,084
Ensembl chrNW_004936508:10,968,656...11,253,070 		JBrowse link
G Snta1 syntrophin alpha 1 ISO SMPDB SMP:00378 NCBI chrNW_004936561:7,101,654...7,134,529
Ensembl chrNW_004936561:7,101,654...7,133,988 		JBrowse link
G Sntb1 syntrophin beta 1 ISO SMPDB SMP:00378 NCBI chrNW_004936470:26,074,175...26,301,076
Ensembl chrNW_004936470:26,073,520...26,303,113 		JBrowse link
G Sntb2 syntrophin beta 2 ISO SMPDB SMP:00378 NCBI chrNW_004936475:19,335,584...19,425,642
Ensembl chrNW_004936475:19,335,664...19,420,683 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00378 NCBI chrNW_004936473:3,290,961...3,293,920
Ensembl chrNW_004936473:3,290,913...3,294,132 		JBrowse link
G Tnnc2 troponin C2, fast skeletal type ISO SMPDB SMP:00378 NCBI chrNW_004936514:7,196,576...7,199,603
Ensembl chrNW_004936514:7,196,536...7,199,649 		JBrowse link
G Tnni1 troponin I1, slow skeletal type ISO SMPDB SMP:00378 NCBI chrNW_004936567:3,013,359...3,025,137
Ensembl chrNW_004936567:3,013,342...3,025,171 		JBrowse link
G Tnni2 troponin I2, fast skeletal type ISO SMPDB SMP:00378 NCBI chrNW_004936816:738,754...741,328
Ensembl chrNW_004936816:740,187...741,210 		JBrowse link
G Tnni3 troponin I3, cardiac type ISO SMPDB SMP:00378 NCBI chrNW_004936886:437,754...440,925
Ensembl chrNW_004936886:437,754...440,458 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO SMPDB SMP:00378 NCBI chrNW_004936886:425,331...434,546
Ensembl chrNW_004936886:425,438...435,500 		JBrowse link
G Tnnt2 troponin T2, cardiac type ISO SMPDB SMP:00378 NCBI chrNW_004936567:3,052,167...3,069,077
Ensembl chrNW_004936567:3,056,845...3,068,887 		JBrowse link
G Tnnt3 troponin T3, fast skeletal type ISO SMPDB SMP:00378 NCBI chrNW_004936816:805,360...822,044
Ensembl chrNW_004936816:805,317...822,043 		JBrowse link
G Tpm1 tropomyosin 1 ISO SMPDB SMP:00378 NCBI chrNW_004936471:23,643,645...23,670,775
Ensembl chrNW_004936471:23,643,613...23,670,775 		JBrowse link
G Tpm2 tropomyosin 2 ISO SMPDB SMP:00378 NCBI chrNW_004936524:3,679,719...3,687,828
Ensembl chrNW_004936524:3,679,560...3,688,308 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3951
    drug pathway 362
      cardiovascular system drug pathway 167
        calcium channel blocker drug pathway 58
          dihydropyridine calcium channel blocker drug pathway 58
            isradipine drug pathway 58
              isradipine pharmacodynamics pathway 58
paths to the root