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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:hypercholesterolemia pathway
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Accession:PW:0001933 term browser browse the term
Definition:A condition resulting from alterations in the various aspects of cholesterol metabolism or transport along with environmental or other diseases related aspects and manifesting in high levels of circulating cholesterol.
Synonyms:exact_synonym: hypercholesterolemia disease pathway
 related_synonym: SMP:00209



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hypercholesterolemia pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT2 acetyl-CoA acetyltransferase 2 ISO SMPDB SMP:00209 NCBI chr 1:7,600,616...7,612,861
Ensembl chr 1:7,598,735...7,612,811
JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 ISO SMPDB SMP:00209 NCBI chr 9:72,057,506...72,079,587
Ensembl chr 9:72,057,511...72,079,444
JBrowse link
G DHCR24 24-dehydrocholesterol reductase ISO SMPDB SMP:00209 NCBI chr 6:157,483,794...157,519,060
Ensembl chr 6:157,483,783...157,579,161
JBrowse link
G EBP EBP cholestenol delta-isomerase ISO SMPDB SMP:00209 NCBI chr  X:42,670,592...42,678,571 JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 ISO SMPDB SMP:00209 NCBI chr14:14,976,259...15,010,701
Ensembl chr14:14,967,273...15,104,179
JBrowse link
G FDPS farnesyl diphosphate synthase ISO SMPDB SMP:00209 NCBI chr 4:94,500,140...94,514,820
Ensembl chr 4:94,489,215...94,518,408
JBrowse link
G GGPS1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00209 NCBI chr14:55,907,885...55,924,037
Ensembl chr14:55,880,316...55,923,988
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB SMP:00209 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,225...84,402,956
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB SMP:00209 NCBI chr16:27,936,225...27,957,261
Ensembl chr16:27,936,217...27,957,194
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 ISO SMPDB SMP:00209 NCBI chr 4:87,720,747...87,743,037
Ensembl chr 4:87,720,118...87,742,992
JBrowse link
G LIPA lipase A, lysosomal acid type ISO SMPDB SMP:00209 NCBI chr14:101,131,372...101,254,739
Ensembl chr14:101,123,381...101,254,725
JBrowse link
G LOC100625049 isopentenyl-diphosphate Delta-isomerase 1 ISO SMPDB SMP:00209 NCBI chr10:68,534,520...68,539,279
Ensembl chr10:68,534,796...68,539,279
JBrowse link
G LSS lanosterol synthase ISO SMPDB SMP:00209
G MSMO1 methylsterol monooxygenase 1 ISO SMPDB SMP:00209 NCBI chr 8:43,726,834...43,745,784
Ensembl chr 8:43,726,855...43,744,714
JBrowse link
G MVD mevalonate diphosphate decarboxylase ISO SMPDB SMP:00209 NCBI chr 6:1,008,100...1,014,303
Ensembl chr 6:1,008,100...1,014,302
JBrowse link
G MVK mevalonate kinase ISO SMPDB SMP:00209 NCBI chr14:41,320,790...41,357,437
Ensembl chr14:41,281,671...41,362,974
JBrowse link
G NSDHL NAD(P) dependent steroid dehydrogenase-like ISO SMPDB SMP:00209 NCBI chr  X:123,906,130...123,921,935
Ensembl chr  X:123,906,194...123,929,117
JBrowse link
G PMVK phosphomevalonate kinase ISO SMPDB SMP:00209 NCBI chr 4:94,861,500...94,913,743
Ensembl chr 4:94,861,694...94,878,921
JBrowse link
G SC5D sterol-C5-desaturase ISO SMPDB SMP:00209 NCBI chr 9:48,357,115...48,372,391
Ensembl chr 9:48,357,145...48,372,388
JBrowse link
G SOAT1 sterol O-acyltransferase 1 ISO SMPDB SMP:00209 NCBI chr 9:121,045,211...121,112,393
Ensembl chr 9:121,045,232...121,113,693
JBrowse link
G SQLE squalene epoxidase ISO SMPDB SMP:00209 NCBI chr 4:14,669,789...14,700,152
Ensembl chr 4:14,669,791...14,700,126
JBrowse link
G TM7SF2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00209 NCBI chr 2:7,076,778...7,081,502
Ensembl chr 2:7,076,778...7,081,429
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4015
    disease pathway 709
      nutritional and metabolic disease pathway 572
        metabolic disease pathway 534
          lipid metabolism disease pathway 94
            hypercholesterolemia pathway 22
paths to the root