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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:hypercholesterolemia pathway
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Accession:PW:0001933 term browser browse the term
Definition:A condition resulting from alterations in the various aspects of cholesterol metabolism or transport along with environmental or other diseases related aspects and manifesting in high levels of circulating cholesterol.
Synonyms:exact_synonym: hypercholesterolemia disease pathway
 related_synonym: SMP:00209


show annotations for term's descendants           Sort by:
hypercholesterolemia pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT2 acetyl-CoA acetyltransferase 2 ISO SMPDB SMP:00209 NCBI chr 6:157,644,894...157,661,965
Ensembl chr 6:162,656,497...162,673,606 		JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 ISO SMPDB SMP:00209 NCBI chr 7:84,110,130...84,132,870
Ensembl chr 7:97,708,806...97,729,824 		JBrowse link
G DHCR24 24-dehydrocholesterol reductase ISO SMPDB SMP:00209 NCBI chr 1:54,126,170...54,163,713
Ensembl chr 1:55,714,693...55,754,698 		JBrowse link
G EBP EBP cholestenol delta-isomerase ISO SMPDB SMP:00209 NCBI chr  X:40,820,042...40,826,957 JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 ISO SMPDB SMP:00209 NCBI chr 8:7,363,250...7,399,863 JBrowse link
G FDPS farnesyl diphosphate synthase ISO SMPDB SMP:00209 NCBI chr 1:130,653,316...130,665,196
Ensembl chr 1:134,258,968...134,270,237 		JBrowse link
G GGPS1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00209 NCBI chr 1:210,874,385...210,888,647
Ensembl chr 1:215,888,966...215,902,845 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB SMP:00209 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB SMP:00209 NCBI chr 5:67,067,001...67,091,786
Ensembl chr 5:72,116,228...72,141,050 		JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 ISO SMPDB SMP:00209 NCBI chr 1:138,204,544...138,226,689 JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 ISO SMPDB SMP:00209 NCBI chr10:1,078,107...1,087,054
Ensembl chr10:1,124,920...1,133,234 		JBrowse link
G LIPA lipase A, lysosomal acid type ISO SMPDB SMP:00209 NCBI chr10:85,938,240...85,976,610
Ensembl chr10:89,477,082...89,516,874 		JBrowse link
G LSS lanosterol synthase ISO SMPDB SMP:00209 NCBI chr21:32,535,564...32,571,379
Ensembl chr21:45,787,252...45,822,181 		JBrowse link
G MSMO1 methylsterol monooxygenase 1 ISO SMPDB SMP:00209 NCBI chr 4:157,523,099...157,538,508
Ensembl chr 4:169,606,809...169,622,212 		JBrowse link
G MVD mevalonate diphosphate decarboxylase ISO SMPDB SMP:00209 NCBI chr16:69,365,070...69,376,149
Ensembl chr16:89,025,572...89,036,964 		JBrowse link
G MVK mevalonate kinase ISO SMPDB SMP:00209 NCBI chr12:107,150,477...107,173,978
Ensembl chr12:110,544,991...110,568,524 		JBrowse link
G NSDHL NAD(P) dependent steroid dehydrogenase-like ISO SMPDB SMP:00209 NCBI chr  X:142,405,340...142,443,723
Ensembl chr  X:152,324,553...152,362,931 		JBrowse link
G PMVK phosphomevalonate kinase ISO SMPDB SMP:00209 NCBI chr 1:130,273,246...130,286,614
Ensembl chr 1:133,882,840...133,894,818 		JBrowse link
G SC5D sterol-C5-desaturase ISO SMPDB SMP:00209 NCBI chr11:116,139,979...116,160,745
Ensembl chr11:120,063,743...120,078,386 		JBrowse link
G SOAT1 sterol O-acyltransferase 1 ISO SMPDB SMP:00209 NCBI chr 1:154,776,305...154,840,594
Ensembl chr 1:158,464,886...158,524,909 		JBrowse link
G SQLE squalene epoxidase ISO SMPDB SMP:00209 NCBI chr 8:121,684,269...121,708,131
Ensembl chr 8:124,435,668...124,459,441 		JBrowse link
G TM7SF2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00209 NCBI chr11:60,473,934...60,478,579
Ensembl chr11:63,812,769...63,816,812 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    disease pathway 714
      nutritional and metabolic disease pathway 581
        metabolic disease pathway 542
          lipid metabolism disease pathway 95
            hypercholesterolemia pathway 22
paths to the root