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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:hyperprolinemia type II pathway
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Accession:PW:0001932 term browser browse the term
Definition:A rare condition resulting from alterations in the proline amino acid metabolic pathway leading to high levels of proline and the related compound pyrroline-5-carboxylase in the circulation.
Synonyms:exact_synonym: 1-pyrroline-5-carboxylate dehydrogenase deficiency pathway;   hyperprolinemia type II disease pathway
 related_synonym: SMP:00360

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hyperprolinemia type II pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 ISO SMPDB SMP:00360 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733 		JBrowse link
G Arg1 arginase 1 ISO SMPDB SMP:00360 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Asl argininosuccinate lyase ISO SMPDB SMP:00360 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341 		JBrowse link
G Ass1 argininosuccinate synthase 1 ISO SMPDB SMP:00360 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826 		JBrowse link
G Ckb creatine kinase B ISO SMPDB SMP:00360 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO SMPDB SMP:00360 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274 		JBrowse link
G Dao D-amino-acid oxidase ISO SMPDB SMP:00360 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784 		JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase ISO SMPDB SMP:00360 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase ISO SMPDB SMP:00360 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998 		JBrowse link
G Gatm glycine amidinotransferase ISO SMPDB SMP:00360 NCBI chr 3:114,711,570...114,728,155
Ensembl chr 3:114,711,562...114,728,410 		JBrowse link
G Glud1 glutamate dehydrogenase 1 ISO SMPDB SMP:00360 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO SMPDB SMP:00360 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO SMPDB SMP:00360 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Oat ornithine aminotransferase ISO SMPDB SMP:00360 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070 		JBrowse link
G Otc ornithine transcarbamylase ISO SMPDB SMP:00360 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069 		JBrowse link
G P4ha3 prolyl 4-hydroxylase subunit alpha 3 ISO SMPDB SMP:00360 NCBI chr 1:165,295,835...165,330,922
Ensembl chr 1:165,295,847...165,330,322 		JBrowse link
G Prodh1 proline dehydrogenase 1 ISO SMPDB SMP:00360 NCBI chr11:87,058,478...87,075,785
Ensembl chr11:87,058,616...87,075,785 		JBrowse link
G Pycr2 pyrroline-5-carboxylate reductase 2 ISO SMPDB SMP:00360 NCBI chr13:99,184,624...99,188,418
Ensembl chr13:99,184,564...99,188,431 		JBrowse link
G Rars2 arginyl-tRNA synthetase 2, mitochondrial ISO SMPDB SMP:00360 NCBI chr 5:50,075,510...50,127,625
Ensembl chr 5:50,075,527...50,127,424 		JBrowse link
G Slc25a15 solute carrier family 25 member 15 ISO SMPDB SMP:00360 NCBI chr16:74,505,318...74,554,523
Ensembl chr16:74,531,564...74,554,529 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6103
    disease pathway 1957
      congenital disease pathway 529
        inborn genetic disease pathway 529
          inborn error of metabolism pathway 529
            inborn error of amino acid metabolism pathway 229
              hyperprolinemia type II pathway 20
paths to the root