Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:naproxen pharmacodynamics pathway
go back to main search page
Accession:PW:0001915 term browser browse the term
Definition:The pathway of naproxen-target interaction and of the biochemical or physiological responses to drug. Naproxen is an inhibitor of cyclooxygenase enzymes used in the treatment of pain and inflammation. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00120


show annotations for term's descendants           Sort by:
naproxen pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB SMP:00120 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00120 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00120 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00120 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B ISO SMPDB SMP:00120 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00120 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB SMP:00120 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00120 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO SMPDB SMP:00120
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB SMP:00120 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO SMPDB SMP:00120 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 ISO SMPDB SMP:00120 NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 ISO SMPDB SMP:00120 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 ISO SMPDB SMP:00120 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00120 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00120 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00120 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00120 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00120 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00120 NCBI chr 3:107,004,238...107,013,853
Ensembl chr 3:107,005,489...107,013,853 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00120 NCBI chr 5:165,462,610...165,465,213 JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00120 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00120 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00120 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00120 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00120 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00120 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    drug pathway 397
      genito-urinary system and sex hormones drug pathway 45
        naproxen drug pathway 27
          naproxen pharmacodynamics pathway 27
Path 2
Term Annotations click to browse term
  pathway 6092
    drug pathway 397
      nervous system drug pathway 183
        analgesic and/or antipyretic drug pathway 97
          naproxen drug pathway 27
            naproxen pharmacodynamics pathway 27
paths to the root