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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:hyperhomocysteinemia pathway
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Accession:PW:0001840 term browser browse the term
Definition:A condition of elevated levels of homocysteine usually due to alteration in folate metabolic pathways. Homocysteine is an intermediate in the methionine metabolic cycle. It can be remethylated to methionine or it can follow the transsulfuration pathway.
Synonyms:exact_synonym: hyperhomocysteinemia disease pathway

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cystathioninuria pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta-synthase ISO SMPDB SMP:00514 NCBI chrNW_004936500:976,043...1,003,559
Ensembl chrNW_004936500:987,128...1,003,388 		JBrowse link
G Cth cystathionine gamma-lyase ISO SMPDB SMP:00514 NCBI chrNW_004936591:1,619,446...1,643,667
Ensembl chrNW_004936591:1,619,446...1,643,665 		JBrowse link
homocystinuria pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase ISO SMPDB SMP:00177 NCBI chrNW_004936561:6,314,797...6,333,961
Ensembl chrNW_004936561:6,314,705...6,334,439 		JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 ISO SMPDB SMP:00177 NCBI chrNW_004936564:6,656,789...6,675,564
Ensembl chrNW_004936564:6,656,746...6,673,462 		JBrowse link
G Cbs cystathionine beta-synthase ISO SMPDB SMP:00177 SMP:00515 NCBI chrNW_004936500:976,043...1,003,559
Ensembl chrNW_004936500:987,128...1,003,388 		JBrowse link
G Chdh choline dehydrogenase ISO SMPDB SMP:00177 NCBI chrNW_004936473:4,479,942...4,512,369
Ensembl chrNW_004936473:4,482,170...4,506,763 		JBrowse link
G Cth cystathionine gamma-lyase ISO SMPDB SMP:00177 SMP:00515 NCBI chrNW_004936591:1,619,446...1,643,667
Ensembl chrNW_004936591:1,619,446...1,643,665 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO SMPDB SMP:00177 NCBI chrNW_004936659:520,181...565,496
Ensembl chrNW_004936659:520,493...565,416 		JBrowse link
G Il4i1 interleukin 4 induced 1 ISO SMPDB SMP:00177 NCBI chrNW_004936664:3,674,612...3,715,036
Ensembl chrNW_004936664:3,675,805...3,686,262 		JBrowse link
G LOC101972215 betaine--homocysteine S-methyltransferase 1 ISO SMPDB SMP:00177 NCBI chrNW_004936549:6,938,100...6,956,380
Ensembl chrNW_004936549:6,938,092...6,957,363 		JBrowse link
G Mars1 methionyl-tRNA synthetase 1 ISO SMPDB SMP:00177 NCBI chrNW_004936646:1,644,457...1,665,081
Ensembl chrNW_004936646:1,644,457...1,665,086 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00177 NCBI chrNW_004936712:1,710,513...1,717,339
Ensembl chrNW_004936712:1,709,716...1,717,499 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit ISO SMPDB SMP:00177 NCBI chrNW_004936515:544,218...561,014
Ensembl chrNW_004936515:544,037...561,182 		JBrowse link
G Msrb2 methionine sulfoxide reductase B2 ISO SMPDB SMP:00177 NCBI chrNW_004936520:5,035,442...5,052,736 JBrowse link
G Msrb3 methionine sulfoxide reductase B3 ISO SMPDB SMP:00177 NCBI chrNW_004936545:3,480,995...3,637,913
Ensembl chrNW_004936545:3,480,853...3,640,924 		JBrowse link
G Mtap methylthioadenosine phosphorylase ISO SMPDB SMP:00177 NCBI chrNW_004936652:3,431,588...3,468,770
Ensembl chrNW_004936652:3,431,171...3,472,071 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00177 NCBI chrNW_004936471:25,334,544...25,352,520
Ensembl chrNW_004936471:25,335,068...25,352,480 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB SMP:00177 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO SMPDB SMP:00177 NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO SMPDB SMP:00177 NCBI chrNW_004936741:1,849,239...1,877,724
Ensembl chrNW_004936741:1,849,609...1,877,727 		JBrowse link
G Srm spermidine synthase ISO SMPDB SMP:00177 NCBI chrNW_004936474:121,135...124,894
Ensembl chrNW_004936474:118,000...124,963 		JBrowse link
methylenetetrahydrofolate reductase deficiency pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase ISO SMPDB SMP:00340 NCBI chrNW_004936561:6,314,797...6,333,961
Ensembl chrNW_004936561:6,314,705...6,334,439 		JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 ISO SMPDB SMP:00340 NCBI chrNW_004936564:6,656,789...6,675,564
Ensembl chrNW_004936564:6,656,746...6,673,462 		JBrowse link
G Cbs cystathionine beta-synthase ISO SMPDB SMP:00340 NCBI chrNW_004936500:976,043...1,003,559
Ensembl chrNW_004936500:987,128...1,003,388 		JBrowse link
G Chdh choline dehydrogenase ISO SMPDB SMP:00340 NCBI chrNW_004936473:4,479,942...4,512,369
Ensembl chrNW_004936473:4,482,170...4,506,763 		JBrowse link
G Cth cystathionine gamma-lyase ISO SMPDB SMP:00340 NCBI chrNW_004936591:1,619,446...1,643,667
Ensembl chrNW_004936591:1,619,446...1,643,665 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO SMPDB SMP:00340 NCBI chrNW_004936659:520,181...565,496
Ensembl chrNW_004936659:520,493...565,416 		JBrowse link
G Il4i1 interleukin 4 induced 1 ISO SMPDB SMP:00340 NCBI chrNW_004936664:3,674,612...3,715,036
Ensembl chrNW_004936664:3,675,805...3,686,262 		JBrowse link
G LOC101972215 betaine--homocysteine S-methyltransferase 1 ISO SMPDB SMP:00340 NCBI chrNW_004936549:6,938,100...6,956,380
Ensembl chrNW_004936549:6,938,092...6,957,363 		JBrowse link
G Mars1 methionyl-tRNA synthetase 1 ISO SMPDB SMP:00340 NCBI chrNW_004936646:1,644,457...1,665,081
Ensembl chrNW_004936646:1,644,457...1,665,086 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00340 NCBI chrNW_004936712:1,710,513...1,717,339
Ensembl chrNW_004936712:1,709,716...1,717,499 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit ISO SMPDB SMP:00340 NCBI chrNW_004936515:544,218...561,014
Ensembl chrNW_004936515:544,037...561,182 		JBrowse link
G Msrb2 methionine sulfoxide reductase B2 ISO SMPDB SMP:00340 NCBI chrNW_004936520:5,035,442...5,052,736 JBrowse link
G Msrb3 methionine sulfoxide reductase B3 ISO SMPDB SMP:00340 NCBI chrNW_004936545:3,480,995...3,637,913
Ensembl chrNW_004936545:3,480,853...3,640,924 		JBrowse link
G Mtap methylthioadenosine phosphorylase ISO SMPDB SMP:00340 NCBI chrNW_004936652:3,431,588...3,468,770
Ensembl chrNW_004936652:3,431,171...3,472,071 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00340 NCBI chrNW_004936471:25,334,544...25,352,520
Ensembl chrNW_004936471:25,335,068...25,352,480 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB SMP:00340 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO SMPDB SMP:00340 NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO SMPDB SMP:00340 NCBI chrNW_004936741:1,849,239...1,877,724
Ensembl chrNW_004936741:1,849,609...1,877,727 		JBrowse link
G Srm spermidine synthase ISO SMPDB SMP:00340 NCBI chrNW_004936474:121,135...124,894
Ensembl chrNW_004936474:118,000...124,963 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3951
    disease pathway 688
      congenital disease pathway 507
        inborn genetic disease pathway 507
          inborn error of metabolism pathway 507
            inborn error of amino acid metabolism pathway 222
              hyperhomocysteinemia pathway 19
                cystathioninuria pathway 2
                homocystinuria pathway + 19
paths to the root