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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:tranexamic acid drug pathway
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Accession:PW:0001786 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of tranexamic acid, an inhibitor of enzymes involved in fibrinolysis and as such, effective in the treatment of certain bleeding disorders It is also used in surgery to prevent excessive bleeding. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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tranexamic acid pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO SMPDB SMP:00287 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00287 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00287 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437 		JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00287 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G F13a1 coagulation factor XIII A1 chain ISO SMPDB SMP:00287 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G F13b coagulation factor XIII B chain ISO SMPDB SMP:00287 NCBI chr13:51,130,908...51,156,383
Ensembl chr13:51,130,920...51,156,381 		JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00287 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00287 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00287 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00287 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00287 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857 		JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00287 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Fga fibrinogen alpha chain ISO SMPDB SMP:00287 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain ISO SMPDB SMP:00287 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain ISO SMPDB SMP:00287 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Ggcx gamma-glutamyl carboxylase ISO SMPDB SMP:00287 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063 		JBrowse link
G Klkb1 kallikrein B1 ISO SMPDB SMP:00287 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Plat plasminogen activator, tissue type ISO SMPDB SMP:00287 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plg plasminogen ISO SMPDB SMP:00287 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 ISO SMPDB SMP:00287 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    drug pathway 397
      blood and blood forming organs drug pathway 62
        antihemorrhagic drug pathway 20
          tranexamic acid drug pathway 20
            tranexamic acid pharmacodynamics pathway 20
            tranexamic acid pharmacokinetics pathway 0
paths to the root