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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:tenofovir drug pathway
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Accession:PW:0001771 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of tenofovir, an antirfetroviral drug used for the treatment of HIV infection and hepatitis B. It is a nucleoside analog reverse transcriptase inhibitor. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.



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tenofovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak1 adenylate kinase 1 ISO SMPDB SMP:00630 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
JBrowse link
G Ak2 adenylate kinase 2 ISO SMPDB SMP:00630 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00630 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 ISO SMPDB SMP:00630 NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    drug pathway 397
      anti-infective drug pathway 27
        tenofovir drug pathway 4
          tenofovir pharmacodynamics pathway 0
          tenofovir pharmacokinetics pathway 4
paths to the root