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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:peptide and protein hormone metabolic pathway
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Accession:PW:0001757 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis, folding and/or degradation of peptide and protein hormones, and those derived from them.


show annotations for term's descendants           Sort by:
angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme IDA RGD PMID:15283675 RGD:1598433 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACE2 angiotensin converting enzyme 2 TAS RGD PMID:15638741 RGD:1581742 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:15951342 RGD:1581938 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor ISO RGD PMID:16520407 RGD:1581931 NCBI chr 6:159,888,787...159,917,447
Ensembl chr 6:159,890,988...159,917,447 		JBrowse link
G MME membrane metalloendopeptidase TAS RGD PMID:15638741 PMID:16520407 RGD:1581742, RGD:1581931 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704 		JBrowse link
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme TAS RGD PMID:15638741 RGD:1581742 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G AGT angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:15590154 RGD:1579760 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISS RGD PMID:14657020 RGD:1566502 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISS RGD PMID:14684844 RGD:1582323 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CMA1 chymase 1 TAS
ISO		 RGD PMID:15638741 PMID:15869764 RGD:1581742, RGD:1581745 NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:16269269 RGD:1600094 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISS RGD PMID:12661921 RGD:1580992 NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISS RGD PMID:14585963 RGD:1581775 NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188 		JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:17613534 RGD:12910844 NCBI chr22:38,111,495...38,181,830
Ensembl chr22:38,111,495...38,214,778 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:16113073 RGD:1642674 NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395 		JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 TAS
ISO		 RGD PMID:10977869 PMID:12446719 PMID:9287353 PMID:14559250 RGD:1581825, RGD:629553, RGD:5133683, RGD:2316188 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTRAP angiotensin II receptor associated protein ISO RGD PMID:17875818 RGD:2314353 NCBI chr 1:11,736,136...11,750,769
Ensembl chr 1:11,736,084...11,754,802 		JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ISO RGD PMID:14559250 RGD:2316188 NCBI chr11:72,685,069...72,752,408
Ensembl chr11:72,685,069...72,793,599 		JBrowse link
G ARRB1 arrestin beta 1 TAS RGD PMID:16304060 RGD:5133417 NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705 		JBrowse link
G ARRB2 arrestin beta 2 TAS RGD PMID:16304060 RGD:5133417 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G GNA11 G protein subunit alpha 11 TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:3,094,362...3,123,999
Ensembl chr19:3,094,362...3,123,999 		JBrowse link
G GNAQ G protein subunit alpha q TAS RGD PMID:16141358 RGD:1581847 NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 TAS RGD PMID:16304060 RGD:5133417 NCBI chr11:67,266,473...67,286,556
Ensembl chr11:67,266,473...67,286,556 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 TAS RGD PMID:16304060 RGD:5133417 NCBI chr22:25,564,675...25,729,294
Ensembl chr22:25,564,675...25,729,294 		JBrowse link
G GRK5 G protein-coupled receptor kinase 5 TAS RGD PMID:16304060 RGD:5133417 NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 TAS RGD PMID:16304060 RGD:5133417 NCBI chr 5:177,425,523...177,442,891
Ensembl chr 5:177,403,204...177,442,901 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:9287353 PMID:9314843 RGD:5133683, RGD:6478796 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G RGS2 regulator of G protein signaling 2 TAS RGD PMID:12588881 RGD:5133418 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275 		JBrowse link
G TYK2 tyrosine kinase 2 ISO RGD PMID:9314843 RGD:6478796 NCBI chr19:10,350,533...10,380,572
Ensembl chr19:10,350,533...10,380,608 		JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen TAS RGD PMID:16286564 PMID:22949090 PMID:16286568 RGD:1582434, RGD:7401256, RGD:1582435 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR2 angiotensin II receptor type 2 TAS RGD PMID:10977869 PMID:22949090 RGD:1581825, RGD:7401256 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G CNKSR1 connector enhancer of kinase suppressor of Ras 1 TAS RGD PMID:20889352 RGD:5133679 NCBI chr 1:26,177,491...26,189,884
Ensembl chr 1:26,177,484...26,189,884 		JBrowse link
G DUSP1 dual specificity phosphatase 1 ISO RGD PMID:18804122 RGD:5133675 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 TAS RGD PMID:20889352 RGD:5133679 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505 		JBrowse link
G GNAI2 G protein subunit alpha i2 TAS RGD PMID:22949090 RGD:7401256 NCBI chr 3:50,227,068...50,263,358
Ensembl chr 3:50,226,292...50,259,362 		JBrowse link
G GNAI3 G protein subunit alpha i3 TAS RGD PMID:22949090 RGD:7401256 NCBI chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195 		JBrowse link
G MTUS1 microtubule associated scaffold protein 1 TAS RGD PMID:20889352 RGD:5133679 NCBI chr 8:17,643,802...17,801,521
Ensembl chr 8:17,643,795...17,801,094 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316 		JBrowse link
G SLC9A6 solute carrier family 9 member A6 TAS RGD PMID:20889352 RGD:5133679 NCBI chr  X:135,973,837...136,047,269
Ensembl chr  X:135,973,841...136,047,269 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 TAS RGD PMID:20889352 RGD:5133679 NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041 		JBrowse link
G ZBTB16 zinc finger and BTB domain containing 16 TAS RGD PMID:20889352 RGD:5133679 NCBI chr11:114,059,711...114,256,770
Ensembl chr11:114,059,041...114,256,765 		JBrowse link
angiotensin III signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11295571 RGD:1582124 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:11295571 RGD:1582124 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:11295571 RGD:1582124 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G ENPEP glutamyl aminopeptidase TAS RGD PMID:15638741 RGD:1581742 NCBI chr 4:110,476,155...110,565,285
Ensembl chr 4:110,365,733...110,565,285 		JBrowse link
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11100981 RGD:1582152 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:11100981 RGD:1582152 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:16380540 RGD:1582118 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:16380540 RGD:1582118 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11282364 RGD:1582105 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G ANPEP alanyl aminopeptidase, membrane TAS RGD PMID:15638741 RGD:1581742 NCBI chr15:89,784,895...89,814,852
Ensembl chr15:89,784,895...89,815,401 		JBrowse link
G LNPEP leucyl and cystinyl aminopeptidase TAS RGD PMID:12591177 RGD:1581864 NCBI chr 5:96,936,080...97,037,513
Ensembl chr 5:96,935,394...97,037,513 		JBrowse link
G RNPEP arginyl aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chr 1:201,982,648...202,006,143
Ensembl chr 1:201,982,372...202,006,147 		JBrowse link
angiotensin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen TAS RGD PMID:12676165 RGD:1566511 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
renin-angiotensin cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme TAS
IEA		 KEGG
RGD		 PMID:15638741 hsa:04614, RGD:1581742 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACE2 angiotensin converting enzyme 2 TAS
IEA		 KEGG
RGD		 PMID:15638741 PMID:16520407 hsa:04614, RGD:1581742, RGD:1581931 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G AGT angiotensinogen TAS
IEA		 KEGG
RGD		 PMID:15638741 hsa:04614, RGD:1581742 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 TAS
IEA		 KEGG
RGD		 PMID:16141358 hsa:04614, RGD:1581847 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 TAS
IEA		 KEGG
RGD		 PMID:15158138 hsa:04614, RGD:1581855 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G ANPEP alanyl aminopeptidase, membrane TAS
IEA		 KEGG
RGD		 PMID:15638741 hsa:04614, RGD:1581742 NCBI chr15:89,784,895...89,814,852
Ensembl chr15:89,784,895...89,815,401 		JBrowse link
G ATP6AP2 ATPase H+ transporting accessory protein 2 TAS RGD PMID:18376005 RGD:5132617 NCBI chr  X:40,580,970...40,606,848
Ensembl chr  X:40,579,372...40,606,848 		JBrowse link
G CMA1 chymase 1 TAS
IEA		 KEGG
RGD		 PMID:15638741 hsa:04614, RGD:1581742 NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265 		JBrowse link
G CPA3 carboxypeptidase A3 IEA KEGG hsa:04614 NCBI chr 3:148,865,296...148,897,203
Ensembl chr 3:148,865,296...148,897,203 		JBrowse link
G CTSA cathepsin A IEA KEGG hsa:04614 NCBI chr20:45,891,335...45,898,820
Ensembl chr20:45,890,144...45,898,949 		JBrowse link
G CTSG cathepsin G IEA KEGG hsa:04614 NCBI chr14:24,573,518...24,576,250
Ensembl chr14:24,573,518...24,576,250 		JBrowse link
G ENPEP glutamyl aminopeptidase TAS
IEA		 KEGG
RGD		 PMID:15638741 hsa:04614, RGD:1581742 NCBI chr 4:110,476,155...110,565,285
Ensembl chr 4:110,365,733...110,565,285 		JBrowse link
G IGF2R insulin like growth factor 2 receptor TAS RGD PMID:16672920 RGD:1581739 NCBI chr 6:159,969,082...160,111,504
Ensembl chr 6:159,969,082...160,113,507 		JBrowse link
G LNPEP leucyl and cystinyl aminopeptidase TAS
IEA		 KEGG
RGD		 PMID:15687842 hsa:04614, RGD:1581849 NCBI chr 5:96,936,080...97,037,513
Ensembl chr 5:96,935,394...97,037,513 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor ISO
IEA		 KEGG
RGD		 PMID:15687842 PMID:16520407 hsa:04614, RGD:1581849, RGD:1581931 NCBI chr 6:159,888,787...159,917,447
Ensembl chr 6:159,890,988...159,917,447 		JBrowse link
G MME membrane metalloendopeptidase TAS
IEA		 KEGG
RGD		 PMID:15638741 PMID:16520407 hsa:04614, RGD:1581742, RGD:1581931 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704 		JBrowse link
G NLN neurolysin IEA KEGG hsa:04614 NCBI chr 5:65,722,205...65,829,283
Ensembl chr 5:65,722,205...65,871,725 		JBrowse link
G REN renin TAS
IEA		 KEGG
RGD		 PMID:16672920 PMID:15638741 hsa:04614, RGD:1581739, RGD:1581742 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G RENBP renin binding protein IDA
ISO		 RGD PMID:11726282 PMID:11726282 RGD:5132613, RGD:5132613 NCBI chr  X:153,935,269...153,944,643
Ensembl chr  X:153,935,269...153,944,687 		JBrowse link
G RNPEP arginyl aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chr 1:201,982,648...202,006,143
Ensembl chr 1:201,982,372...202,006,147 		JBrowse link
G THOP1 thimet oligopeptidase 1 IEA KEGG hsa:04614 NCBI chr19:2,785,503...2,815,807
Ensembl chr19:2,785,503...2,815,807 		JBrowse link
thyroid hormone biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYBA cytochrome b-245 alpha chain EXP SMPDB SMP:00716 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G CYBB cytochrome b-245 beta chain EXP SMPDB SMP:00716 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G DUOX1 dual oxidase 1 EXP SMPDB SMP:00716 NCBI chr15:45,129,994...45,165,574
Ensembl chr15:45,129,933...45,165,576 		JBrowse link
G DUOX2 dual oxidase 2 EXP SMPDB SMP:00716 NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172 		JBrowse link
G NOX3 NADPH oxidase 3 EXP SMPDB SMP:00716 NCBI chr 6:155,395,368...155,455,839
Ensembl chr 6:155,395,368...155,455,839 		JBrowse link
G NOX4 NADPH oxidase 4 EXP SMPDB SMP:00716 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187 		JBrowse link
G SLC26A4 solute carrier family 26 member 4 EXP SMPDB SMP:00716 NCBI chr 7:107,660,828...107,717,809
Ensembl chr 7:107,660,828...107,717,809 		JBrowse link
G SLC5A5 solute carrier family 5 member 5 EXP SMPDB SMP:00716 NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174 		JBrowse link
G TG thyroglobulin EXP SMPDB SMP:00716 NCBI chr 8:132,866,958...133,134,899
Ensembl chr 8:132,866,958...133,134,903 		JBrowse link
G TPO thyroid peroxidase EXP SMPDB SMP:00716 NCBI chr 2:1,374,047...1,543,673
Ensembl chr 2:1,374,066...1,543,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    classic metabolic pathway 1803
      peptide and protein metabolic pathway 74
        peptide and protein hormone metabolic pathway 59
          insulin biosynthetic pathway 0
          preproglucagon processing pathway + 0
          renin-angiotensin cascade pathway + 49
          somatostatin biosynthetic pathway 0
          thyroglobulin processing pathway + 10
          thyroid-stimulating hormone biosynthetic pathway 0
          thyrotropin-releasing hormone biosynthetic pathway 0
paths to the root