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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:peptide and protein hormone metabolic pathway
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Accession:PW:0001757 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis, folding and/or degradation of peptide and protein hormones, and those derived from them.


show annotations for term's descendants           Sort by:
angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO RGD PMID:10642323 PMID:15283675 RGD:1581953 RGD:1598433 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chr  X:11,798,839...11,839,591
Ensembl chr  X:11,798,839...11,900,594 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:15951342 RGD:1581938 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor ISO RGD PMID:15951342 PMID:16520407 RGD:1581931 RGD:1581938 NCBI chr 1:49,090,041...49,105,244
Ensembl chr 1:49,090,041...49,105,244 		JBrowse link
G MME membrane metalloendopeptidase ISO RGD PMID:10642323 PMID:15638741 PMID:16520407 RGD:1581742 RGD:1581931 RGD:1581953 NCBI chr23:48,966,222...49,059,919
Ensembl chr23:48,971,066...49,059,919 		JBrowse link
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO RGD PMID:15638741 RGD:1581742 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:16141358 RGD:1581847 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:15590154 RGD:1579760 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:14657020 RGD:1566502 NCBI chr  X:88,703,551...88,708,451
Ensembl chr  X:88,705,765...88,706,853 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:14684844 RGD:1582323 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CMA1 chymase 1 ISO RGD PMID:15638741 PMID:15869764 RGD:1581742 RGD:1581745 NCBI chr 8:4,438,244...4,441,189
Ensembl chr 8:4,438,244...4,441,189 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:16269269 RGD:1600094 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISO RGD PMID:12661921 RGD:1580992 NCBI chr27:35,828,852...35,838,748
Ensembl chr27:35,828,029...35,838,754 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO RGD PMID:14585963 RGD:1581775 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295 		JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:17613534 RGD:12910844 NCBI chr10:26,499,033...26,559,533
Ensembl chr10:26,509,695...26,634,087 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:16113073 RGD:1642674 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:16141358 RGD:1581847 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:9287353 PMID:10977869 PMID:12446719 PMID:14559250 RGD:1581825 RGD:2316188 RGD:5133683 RGD:629553 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238 		JBrowse link
G AGTRAP angiotensin II receptor associated protein ISO RGD PMID:17875818 RGD:2314353 NCBI chr 2:84,489,269...84,501,732
Ensembl chr 2:84,490,638...84,501,919 		JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ISO RGD PMID:14559250 RGD:2316188 NCBI chr21:25,468,653...25,531,644
Ensembl chr21:25,443,386...25,531,165 		JBrowse link
G ARRB1 arrestin beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr21:23,261,020...23,304,448
Ensembl chr21:23,235,711...23,297,786 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454 		JBrowse link
G GNA11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847
G GNAQ G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr26:19,385,059...19,512,528
Ensembl chr26:19,385,058...19,516,077 		JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr28:29,424,350...29,636,552
Ensembl chr28:29,424,593...29,632,741 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 4:35,927,470...35,943,218
Ensembl chr 4:35,913,472...35,943,221 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:9287353 PMID:9314843 RGD:5133683 RGD:6478796 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997 		JBrowse link
G RGS2 regulator of G protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr38:6,200,237...6,203,491
Ensembl chr38:6,200,657...6,203,494 		JBrowse link
G TYK2 tyrosine kinase 2 ISO RGD PMID:9314843 RGD:6478796 NCBI chr20:50,747,145...50,770,008
Ensembl chr20:50,748,329...50,769,216 		JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:16286564 PMID:16286568 PMID:22949090 RGD:1582434 RGD:1582435 RGD:7401256 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:10977869 PMID:22949090 RGD:1581825 RGD:7401256 NCBI chr  X:88,703,551...88,708,451
Ensembl chr  X:88,705,765...88,706,853 		JBrowse link
G CNKSR1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 2:73,805,333...73,814,711
Ensembl chr 2:73,805,710...73,814,725 		JBrowse link
G DUSP1 dual specificity phosphatase 1 ISO RGD PMID:18804122 RGD:5133675 NCBI chr 4:39,588,833...39,591,065
Ensembl chr 4:39,588,339...39,590,514 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr10:406,856...424,746
Ensembl chr10:406,633...424,264 		JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:22949090 RGD:7401256 NCBI chr20:39,075,085...39,094,697
Ensembl chr20:39,075,085...39,094,697 		JBrowse link
G GNAI3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 6:42,275,060...42,315,545
Ensembl chr 6:42,276,998...42,315,533 		JBrowse link
G MTUS1 microtubule associated scaffold protein 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr16:40,955,619...41,118,601
Ensembl chr16:40,957,574...41,068,967 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chr27:38,084,976...38,101,552
Ensembl chr27:38,084,980...38,101,937 		JBrowse link
G SLC9A6 solute carrier family 9 member A6 ISO RGD PMID:20889352 RGD:5133679 NCBI chr  X:106,408,789...106,465,504
Ensembl chr  X:106,398,850...106,463,252 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr10:30,627,154...30,681,520
Ensembl chr10:30,627,154...30,694,288 		JBrowse link
G ZBTB16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 5:19,082,594...19,284,360
Ensembl chr 5:19,087,154...19,267,628 		JBrowse link
angiotensin III signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11295571 RGD:1582124 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:11295571 RGD:1582124 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:11295571 RGD:1582124 NCBI chr  X:88,703,551...88,708,451
Ensembl chr  X:88,705,765...88,706,853 		JBrowse link
G ENPEP glutamyl aminopeptidase ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chr32:30,553,055...30,639,790
Ensembl chr32:30,553,182...30,638,522 		JBrowse link
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11100981 RGD:1582152 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:11100981 RGD:1582152 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238 		JBrowse link
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:16380540 RGD:1582118 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:16380540 RGD:1582118 NCBI chr  X:88,703,551...88,708,451
Ensembl chr  X:88,705,765...88,706,853 		JBrowse link
angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11282364 RGD:1582105 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G ANPEP alanyl aminopeptidase, membrane ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chr 3:52,764,418...52,779,516
Ensembl chr 3:52,764,418...52,779,746 		JBrowse link
G LNPEP leucyl and cystinyl aminopeptidase ISO RGD PMID:11282364 PMID:12591177 RGD:1581864 RGD:1582105 NCBI chr 3:12,668,994...12,766,712
Ensembl chr 3:12,681,577...12,767,183 		JBrowse link
G RNPEP arginyl aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chr 7:966,563...985,169
Ensembl chr 7:966,607...984,714 		JBrowse link
angiotensin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:12676165 RGD:1566511 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
renin-angiotensin cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO RGD PMID:10642323 PMID:15638741 RGD:1581742 RGD:1581953 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO RGD PMID:15638741 PMID:16520407 RGD:1581742 RGD:1581931 NCBI chr  X:11,798,839...11,839,591
Ensembl chr  X:11,798,839...11,900,594 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:11282364 PMID:12242043 PMID:15638741 RGD:1581651 RGD:1581742 RGD:1582105 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:16141358 RGD:1581847 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:15158138 RGD:1581855 NCBI chr  X:88,703,551...88,708,451
Ensembl chr  X:88,705,765...88,706,853 		JBrowse link
G ANPEP alanyl aminopeptidase, membrane ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chr 3:52,764,418...52,779,516
Ensembl chr 3:52,764,418...52,779,746 		JBrowse link
G ATP6AP2 ATPase H+ transporting accessory protein 2 ISO RGD PMID:18376005 RGD:5132617 NCBI chr  X:35,050,588...35,073,633
Ensembl chr  X:35,050,606...35,073,067 		JBrowse link
G CMA1 chymase 1 ISO RGD PMID:15638741 RGD:1581742 NCBI chr 8:4,438,244...4,441,189
Ensembl chr 8:4,438,244...4,441,189 		JBrowse link
G ENPEP glutamyl aminopeptidase ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chr32:30,553,055...30,639,790
Ensembl chr32:30,553,182...30,638,522 		JBrowse link
G IGF2R insulin like growth factor 2 receptor ISO RGD PMID:11247783 PMID:16672920 RGD:1581738 RGD:1581739 NCBI chr 1:49,161,551...49,262,260
Ensembl chr 1:49,161,444...49,262,277 		JBrowse link
G LNPEP leucyl and cystinyl aminopeptidase ISO RGD PMID:11282364 PMID:15687842 RGD:1581849 RGD:1582105 NCBI chr 3:12,668,994...12,766,712
Ensembl chr 3:12,681,577...12,767,183 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor ISO RGD PMID:15687842 PMID:16520407 RGD:1581849 RGD:1581931 NCBI chr 1:49,090,041...49,105,244
Ensembl chr 1:49,090,041...49,105,244 		JBrowse link
G MME membrane metalloendopeptidase ISO RGD PMID:10642323 PMID:15638741 PMID:16520407 RGD:1581742 RGD:1581931 RGD:1581953 NCBI chr23:48,966,222...49,059,919
Ensembl chr23:48,971,066...49,059,919 		JBrowse link
G REN renin ISO RGD PMID:11247783 PMID:12242043 PMID:15638741 PMID:16672920 RGD:1581651 RGD:1581738 RGD:1581739 RGD:1581742 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
G RENBP renin binding protein ISO RGD PMID:11726282 RGD:5132613 NCBI chr  X:121,782,411...121,788,928
Ensembl chr  X:121,727,573...121,788,860 		JBrowse link
G RNPEP arginyl aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chr 7:966,563...985,169
Ensembl chr 7:966,607...984,714 		JBrowse link
thyroid hormone biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYBA cytochrome b-245 alpha chain ISO SMPDB SMP:00716 NCBI chr 5:64,692,865...64,701,056
Ensembl chr 5:64,692,123...64,704,893 		JBrowse link
G CYBB cytochrome b-245 beta chain ISO SMPDB SMP:00716 NCBI chr  X:32,533,365...32,568,149
Ensembl chr  X:32,533,320...32,568,217 		JBrowse link
G DUOX1 dual oxidase 1 ISO SMPDB SMP:00716 NCBI chr30:11,556,024...11,588,203
Ensembl chr30:11,556,024...11,588,202 		JBrowse link
G DUOX2 dual oxidase 2 ISO SMPDB SMP:00716 NCBI chr30:11,521,833...11,541,719
Ensembl chr30:11,521,845...11,541,716 		JBrowse link
G NOX3 NADPH oxidase 3 ISO SMPDB SMP:00716 NCBI chr 1:45,129,112...45,186,510
Ensembl chr 1:45,128,958...45,186,510 		JBrowse link
G NOX4 NADPH oxidase 4 ISO SMPDB SMP:00716 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277 		JBrowse link
G SLC26A4 solute carrier family 26 member 4 ISO SMPDB SMP:00716 NCBI chr18:12,894,347...12,941,669
Ensembl chr18:12,894,669...12,943,212 		JBrowse link
G SLC5A5 solute carrier family 5 member 5 ISO SMPDB SMP:00716 NCBI chr20:45,017,939...45,030,598
Ensembl chr20:45,018,119...45,030,209 		JBrowse link
G TG thyroglobulin ISO SMPDB SMP:00716 NCBI chr13:29,350,726...29,597,908
Ensembl chr13:29,350,688...29,598,040 		JBrowse link
G TPO thyroid peroxidase ISO SMPDB SMP:00716 NCBI chr17:773,790...810,044
Ensembl chr17:773,790...810,043 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4049
    classic metabolic pathway 1010
      peptide and protein metabolic pathway 69
        peptide and protein hormone metabolic pathway 54
          insulin biosynthetic pathway 0
          preproglucagon processing pathway + 0
          renin-angiotensin cascade pathway + 44
          somatostatin biosynthetic pathway 0
          thyroglobulin processing pathway + 10
          thyroid-stimulating hormone biosynthetic pathway 0
          thyrotropin-releasing hormone biosynthetic pathway 0
paths to the root