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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:S-adenosylmethionine homeostasis pathway
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Accession:PW:0001693 term browser browse the term
Definition:Those pathways that involve the balanced generation and utilization of S-adenosylmethionine (AdoMet or SAM). SAM is a universal methyl donor and at the cross roads of metabolism, gene expression regulation and cellular signaling.
Synonyms:related_synonym: AdoMet homeostasis pathway;   SAM homeostasis pathway


show annotations for term's descendants           Sort by:
altered DNA modification pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MBD4 methyl-CpG binding domain 4, DNA glycosylase ISO in silico assessment of loss of DNA-protein interactions and observed enhancement of DNA repair capacity (DRC) in the context of nucleotide excision repair (NER) pathway for SNP RGD PMID:24004570 RGD:9588971 NCBI chr13:68,816,677...68,828,559
Ensembl chr13:68,816,679...68,828,580 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 7:53,748,585...53,794,777
Ensembl chr 7:53,748,653...53,794,706 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 2:89,230,660...89,255,830 JBrowse link
G FOLR1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 9:6,753,513...6,760,433
Ensembl chr 9:6,757,040...6,760,402 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr 7:88,471,317...88,533,690
Ensembl chr 7:88,471,414...88,537,387 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr12:44,677,499...44,686,277
Ensembl chr12:44,677,502...44,686,250 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 7:88,471,317...88,533,690
Ensembl chr 7:88,471,414...88,537,387 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
DNA modification pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXXC1 CXXC finger protein 1 ISO RGD PMID:23697932 RGD:9479164 NCBI chr 1:99,934,493...99,940,125
Ensembl chr 1:99,934,497...99,940,130 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr17:36,345,715...36,386,076
Ensembl chr17:36,345,816...36,386,072 		JBrowse link
G EBF1 EBF transcription factor 1 ISO RGD PMID:24825349 RGD:8695944 NCBI chr16:64,357,999...64,753,188
Ensembl chr16:64,359,001...64,752,210 		JBrowse link
G KDM2A lysine demethylase 2A ISO RGD PMID:23697932 RGD:9479164 NCBI chr 2:5,238,690...5,357,799
Ensembl chr 2:5,240,312...5,357,829 		JBrowse link
G KDM2B lysine demethylase 2B ISO RGD PMID:23697932 RGD:9479164 NCBI chr14:31,057,121...31,203,093
Ensembl chr14:31,165,950...31,203,091 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO RGD PMID:23697932 RGD:9479164 NCBI chr 9:45,743,566...45,828,559
Ensembl chr 9:45,743,397...45,824,884 		JBrowse link
G KMT2C lysine methyltransferase 2C ISO RGD PMID:23697932 RGD:9479164 NCBI chr18:4,993,213...5,279,668
Ensembl chr18:4,993,227...5,278,723 		JBrowse link
G MBD1 methyl-CpG binding domain protein 1 ISO RGD PMID:23324617 RGD:8695954 NCBI chr 1:99,848,193...99,917,347
Ensembl chr 1:99,900,801...99,917,323 		JBrowse link
G MBD2 methyl-CpG binding domain protein 2 ISO RGD PMID:23324617 RGD:8695954 NCBI chr 1:103,683,077...103,768,372
Ensembl chr 1:103,735,192...103,752,402 		JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase ISO RGD PMID:23324617 RGD:8695954 NCBI chr13:68,816,677...68,828,559
Ensembl chr13:68,816,679...68,828,580 		JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO RGD PMID:23324617 RGD:8695954 NCBI chr  X:124,735,523...124,789,063
Ensembl chr  X:124,735,656...124,738,659 		JBrowse link
G NANOG Nanog homeobox ISO RGD PMID:24825349 RGD:8695944 NCBI chr 5:62,931,642...62,939,086
Ensembl chr 5:62,932,382...62,939,082 		JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase ISO RGD PMID:24825349 RGD:8695944 NCBI chr  X:57,521,091...57,558,467
Ensembl chr  X:57,521,098...57,558,515 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:24825349 RGD:8695944 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
G PRDM14 PR/SET domain 14 ISO RGD PMID:24825349 RGD:8695944 NCBI chr 4:65,273,988...65,295,362
Ensembl chr 4:65,271,315...65,295,178 		JBrowse link
G SIN3A SIN3 transcription regulator family member A ISO RGD PMID:24825349 RGD:8695944 NCBI chr 7:58,171,821...58,246,126
Ensembl chr 7:58,176,167...58,245,971 		JBrowse link
G SPI1 Spi-1 proto-oncogene ISO RGD PMID:24825349 RGD:8695944 NCBI chr 2:15,227,850...15,245,679
Ensembl chr 2:15,227,881...15,245,677 		JBrowse link
G TET1 tet methylcytosine dioxygenase 1 ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr14:71,675,671...71,812,732
Ensembl chr14:71,675,671...71,815,618 		JBrowse link
G TET2 tet methylcytosine dioxygenase 2 ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr 8:116,413,253...116,546,976
Ensembl chr 8:116,415,267...116,545,299 		JBrowse link
G TET3 tet methylcytosine dioxygenase 3 ISO RGD PMID:22770212 PMID:23697932 PMID:24825349 RGD:8695943 RGD:8695944 RGD:9479164 NCBI chr 3:68,918,896...69,020,406
Ensembl chr 3:68,918,933...69,020,986 		JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 ISO RGD PMID:23324617 RGD:8695954 NCBI chr 2:73,898,061...73,937,727
Ensembl chr 2:73,898,071...73,931,769 		JBrowse link
G UHRF2 ubiquitin like with PHD and ring finger domains 2 ISO RGD PMID:23324617 RGD:8695954 NCBI chr 1:215,730,212...215,807,630
Ensembl chr 1:215,730,225...215,807,627 		JBrowse link
G ZBTB33 zinc finger and BTB domain containing 33 ISO RGD PMID:23324617 RGD:8695954 NCBI chr  X:98,370,137...98,413,686
Ensembl chr  X:98,405,319...98,414,279 		JBrowse link
G ZBTB38 zinc finger and BTB domain containing 38 ISO RGD PMID:23324617 RGD:8695954 NCBI chr13:82,053,887...82,195,321
Ensembl chr13:82,064,565...82,195,319 		JBrowse link
G ZBTB4 zinc finger and BTB domain containing 4 ISO RGD PMID:23324617 RGD:8695954 NCBI chr12:52,759,912...52,775,725 JBrowse link
G ZFP57 ZFP57 zinc finger protein ISO RGD PMID:23324617 RGD:8695954 NCBI chr 7:22,607,420...22,612,064
Ensembl chr 7:22,605,125...22,612,064 		JBrowse link
folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 7:53,748,585...53,794,777
Ensembl chr 7:53,748,653...53,794,706 		JBrowse link
G AMT aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chr13:31,995,600...32,002,514
Ensembl chr13:31,995,595...32,002,470 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 2:89,230,660...89,255,830 JBrowse link
G DLD dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 9:107,642,129...107,668,443
Ensembl chr 9:107,642,095...107,673,583 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 2:87,791,827...87,867,189
Ensembl chr 2:87,791,943...87,866,679 		JBrowse link
G FOLH1B folate hydrolase 1B ISO RGD PMID:16859665 PMID:20814827 RGD:7242426 RGD:7242559 NCBI chr 9:22,903,997...22,960,648
Ensembl chr 9:22,903,979...22,963,472 		JBrowse link
G FOLR1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 9:6,753,513...6,760,433
Ensembl chr 9:6,757,040...6,760,402 		JBrowse link
G FOLR2 folate receptor 2 (fetal) ISO RGD PMID:22108709 RGD:7242557 NCBI chr 9:6,785,308...6,790,466
Ensembl chr 9:6,785,303...6,790,465 		JBrowse link
G FPGS folylpolyglutamate synthase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 1:268,281,298...268,309,397
Ensembl chr 1:268,287,765...268,309,398 		JBrowse link
G GCSH glycine cleavage system protein H ISO RGD PMID:20645850 RGD:7242560 NCBI chr 6:7,171,186...7,184,732
Ensembl chr 6:7,171,192...7,184,729 		JBrowse link
G GGH gamma-glutamyl hydrolase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 4:70,996,730...71,020,513
Ensembl chr 4:70,996,755...71,021,838 		JBrowse link
G GLDC glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 1:215,608,854...215,715,062
Ensembl chr 1:215,608,849...215,715,059 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr 7:88,471,317...88,533,690
Ensembl chr 7:88,471,414...88,537,387 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:15,140,929...15,330,265
Ensembl chr 1:15,140,899...15,329,986 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chr 3:68,819,171...68,833,641
Ensembl chr 3:68,818,119...68,833,600 		JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 8:70,179,701...70,288,356
Ensembl chr 8:70,179,658...70,290,047 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783 		JBrowse link
G SARDH sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 1:273,230,357...273,295,170
Ensembl chr 1:273,230,375...273,294,621 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr12:60,414,421...60,435,451
Ensembl chr12:60,416,463...60,435,450 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chr 5:22,535,780...22,540,322
Ensembl chr 5:22,532,894...22,540,319 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chr13:207,986,094...208,007,855
Ensembl chr13:207,986,098...208,007,675 		JBrowse link
G SLC25A32 solute carrier family 25 member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chr 4:33,704,810...33,727,796
Ensembl chr 4:33,704,771...33,730,130 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chr12:44,677,499...44,686,277
Ensembl chr12:44,677,502...44,686,250 		JBrowse link
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:14729668 RGD:1547843 NCBI chr 7:53,748,585...53,794,777
Ensembl chr 7:53,748,653...53,794,706 		JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:9332377 PMID:22332074 RGD:70804 RGD:7242561 NCBI chr15:117,617,584...117,649,063
Ensembl chr15:117,617,502...117,649,107 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:11502523 PMID:22332074 RGD:1298877 RGD:7242561 NCBI chr 2:89,230,660...89,255,830 JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chr 2:87,791,827...87,867,189
Ensembl chr 2:87,791,943...87,866,679 		JBrowse link
G FOLH1B folate hydrolase 1B ISO RGD PMID:9501243 RGD:728645 NCBI chr 9:22,903,997...22,960,648
Ensembl chr 9:22,903,979...22,963,472 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 PMID:22332074 RGD:1547842 RGD:7242561 NCBI chr13:197,130,898...197,158,797
Ensembl chr13:197,130,904...197,161,891 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:8278367 RGD:1545057 NCBI chr 7:38,038,359...38,041,218
Ensembl chr 7:38,038,358...38,041,217 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:2186031 PMID:22332074 RGD:1299513 RGD:7242561 NCBI chr 7:88,471,317...88,533,690
Ensembl chr 7:88,471,414...88,537,387 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:9454603 RGD:1540378 NCBI chr 3:68,819,171...68,833,641
Ensembl chr 3:68,818,119...68,833,600 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:11933257 PMID:22332074 RGD:1535021 RGD:7242561 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 PMID:20814827 RGD:1359026 RGD:7242426 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chr12:60,414,421...60,435,451
Ensembl chr12:60,416,463...60,435,450 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chr 5:22,535,780...22,540,322
Ensembl chr 5:22,532,894...22,540,319 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:9894005 PMID:22332074 RGD:1545055 RGD:7242561 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
folate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO SMPDB
RGD		 PMID:14729668 RGD:1547843 SMP:00053 NCBI chr 7:53,748,585...53,794,777
Ensembl chr 7:53,748,653...53,794,706 		JBrowse link
G DHFR dihydrofolate reductase ISO SMPDB
RGD		 PMID:11502523 RGD:1298877 SMP:00053 NCBI chr 2:89,230,660...89,255,830 JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chr 2:87,791,827...87,867,189
Ensembl chr 2:87,791,943...87,866,679 		JBrowse link
G FOLH1B folate hydrolase 1B ISO RGD PMID:9816319 RGD:151347637 NCBI chr 9:22,903,997...22,960,648
Ensembl chr 9:22,903,979...22,963,472 		JBrowse link
G FOLR2 folate receptor 2 (fetal) ISO RGD PMID:8445646 RGD:1540379 NCBI chr 9:6,785,308...6,790,466
Ensembl chr 9:6,785,303...6,790,465 		JBrowse link
G FPGS folylpolyglutamate synthase ISO SMPDB SMP:00053 NCBI chr 1:268,281,298...268,309,397
Ensembl chr 1:268,287,765...268,309,398 		JBrowse link
G FTCD formimidoyltransferase cyclodeaminase ISO SMPDB SMP:00053
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 RGD:1547842 NCBI chr13:197,130,898...197,158,797
Ensembl chr13:197,130,904...197,161,891 		JBrowse link
G GGH gamma-glutamyl hydrolase ISO SMPDB SMP:00053 NCBI chr 4:70,996,730...71,020,513
Ensembl chr 4:70,996,755...71,021,838 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:15347642 RGD:1359070 NCBI chr 7:38,038,359...38,041,218
Ensembl chr 7:38,038,358...38,041,217 		JBrowse link
G LOC102167410 5-formyltetrahydrofolate cyclo-ligase ISO SMPDB SMP:00053 NCBI chr 7:48,717,518...48,873,492
Ensembl chr 7:48,717,851...48,873,455 		JBrowse link
G MTFMT mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00053 NCBI chr 1:106,970,620...107,001,563
Ensembl chr 1:106,970,640...107,001,564 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO SMPDB
RGD		 PMID:2186031 RGD:1299513 SMP:00053 NCBI chr 7:88,471,317...88,533,690
Ensembl chr 7:88,471,414...88,537,387 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO SMPDB SMP:00053 NCBI chr 1:15,140,929...15,330,265
Ensembl chr 1:15,140,899...15,329,986 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB
RGD		 PMID:9454603 RGD:1540378 SMP:00053 NCBI chr 3:68,819,171...68,833,641
Ensembl chr 3:68,818,119...68,833,600 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO SMPDB
RGD		 PMID:11933257 RGD:1535021 SMP:00053 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 RGD:1359026 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 RGD:1359037 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:15671219 RGD:1359815 NCBI chr12:60,414,421...60,435,451
Ensembl chr12:60,416,463...60,435,450 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:15671219 RGD:1359815 NCBI chr 5:22,535,780...22,540,322
Ensembl chr 5:22,532,894...22,540,319 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO RGD PMID:11600421 RGD:735239 NCBI chr13:207,986,094...208,007,855
Ensembl chr13:207,986,098...208,007,675 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO SMPDB SMP:00053 NCBI chr12:44,677,499...44,686,277
Ensembl chr12:44,677,502...44,686,250 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:9894005 RGD:1545055 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
histone modification pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AEBP2 AE binding protein 2 ISO RGD PMID:24148750 RGD:9479059 NCBI chr 5:53,617,362...53,691,487
Ensembl chr 5:53,617,358...53,691,509 		JBrowse link
G APLF aprataxin and PNKP like factor ISO RGD PMID:23288364 RGD:9068945 NCBI chr 3:73,752,115...73,831,158
Ensembl chr 3:73,752,118...73,831,035 		JBrowse link
G ASF1A anti-silencing function 1A histone chaperone ISO RGD PMID:23288364 RGD:9068945 NCBI chr 1:43,200,339...43,215,019
Ensembl chr 1:43,200,415...43,214,913 		JBrowse link
G ASF1B anti-silencing function 1B histone chaperone ISO RGD PMID:23288364 RGD:9068945 NCBI chr 2:65,063,186...65,072,681
Ensembl chr 2:65,062,766...65,072,679 		JBrowse link
G ASH1L ASH1 like histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr 4:94,297,532...94,484,994
Ensembl chr 4:94,297,616...94,484,990 		JBrowse link
G ASH2L ASH2 like, histone lysine methyltransferase complex subunit ISO RGD PMID:22663077 RGD:9479053 NCBI chr15:48,386,426...48,417,560
Ensembl chr15:48,386,425...48,417,547 		JBrowse link
G BAP1 BRCA1 associated deubiquitinase 1 ISO RGD PMID:24647359 RGD:9479061 NCBI chr13:34,544,570...34,553,538
Ensembl chr13:34,544,581...34,553,483 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISO RGD PMID:23642229 RGD:9479074 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215 		JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr10:52,586,089...52,596,154
Ensembl chr10:52,586,509...52,596,564 		JBrowse link
G BPTF bromodomain PHD finger transcription factor ISO RGD PMID:23642229 PMID:24686119 RGD:9479074 RGD:9479075 NCBI chr12:14,112,943...14,254,810
Ensembl chr12:14,112,718...14,254,790 		JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 ISO RGD PMID:24647359 RGD:9479061 NCBI chr  X:125,383,392...125,439,082
Ensembl chr  X:125,383,414...125,439,082 		JBrowse link
G BRD1 bromodomain containing 1 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 5:774,307...808,016
Ensembl chr 5:770,654...808,006 		JBrowse link
G BRD2 bromodomain containing 2 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 7:25,096,579...25,162,591
Ensembl chr 7:25,152,043...25,162,578 		JBrowse link
G BRD4 bromodomain containing 4 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 2:62,250,958...62,345,851
Ensembl chr 2:62,250,989...62,345,362 		JBrowse link
G BRD7 bromodomain containing 7 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 6:34,478,008...34,519,622
Ensembl chr 6:34,478,012...34,519,663 		JBrowse link
G BRDT bromodomain testis associated ISO RGD PMID:24686119 RGD:9479075 NCBI chr 4:125,004,897...125,062,208
Ensembl chr 4:125,004,494...125,060,392 		JBrowse link
G BRF1 BRF1 RNA polymerase III transcription initiation factor subunit ISO RGD PMID:23642229 RGD:9479074
G CARM1 coactivator associated arginine methyltransferase 1 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 2:69,602,121...69,644,862
Ensembl chr 2:69,602,136...69,644,854 		JBrowse link
G CBX2 chromobox 2 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr12:2,570,841...2,580,336
Ensembl chr12:2,570,851...2,580,337 		JBrowse link
G CBX4 chromobox 4 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr12:2,520,913...2,527,245
Ensembl chr12:2,521,027...2,527,241 		JBrowse link
G CBX5 chromobox 5 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 5:19,446,083...19,484,527
Ensembl chr 5:19,446,086...19,484,463 		JBrowse link
G CBX6 chromobox 6 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 5:9,180,559...9,191,414
Ensembl chr 5:9,180,684...9,188,620 		JBrowse link
G CBX7 chromobox 7 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 5:9,070,312...9,090,467
Ensembl chr 5:9,070,353...9,087,634 		JBrowse link
G CBX8 chromobox 8 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr12:2,562,419...2,565,035
Ensembl chr12:2,562,374...2,565,780 		JBrowse link
G CHAF1A chromatin assembly factor 1 subunit A ISO RGD PMID:23288364 RGD:9068945 NCBI chr 2:74,380,706...74,411,875
Ensembl chr 2:74,380,709...74,411,825 		JBrowse link
G CHAF1B chromatin assembly factor 1 subunit B ISO RGD PMID:23288364 RGD:9068945 NCBI chr13:200,048,096...200,074,902
Ensembl chr13:200,048,149...200,072,556 		JBrowse link
G CHD1 chromodomain helicase DNA binding protein 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 2:105,113,149...105,205,303
Ensembl chr 2:105,113,668...105,203,119 		JBrowse link
G CREBBP CREB binding protein ISO RGD PMID:21151613 PMID:24686119 RGD:9104959 RGD:9479075 NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224 		JBrowse link
G CXXC1 CXXC finger protein 1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr 1:99,934,493...99,940,125
Ensembl chr 1:99,934,497...99,940,130 		JBrowse link
G DAXX death domain associated protein ISO RGD PMID:23288364 RGD:9068945 NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,856...29,681,110 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr 2:76,339,452...76,401,974
Ensembl chr 2:76,339,470...76,401,965 		JBrowse link
G DPF3 double PHD fingers 3 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 7:95,974,422...96,254,354
Ensembl chr 7:95,982,462...96,254,318 		JBrowse link
G DPY30 dpy-30 histone methyltransferase complex regulatory subunit ISO RGD PMID:22663077 RGD:9479053 NCBI chr 3:107,520,641...107,533,504
Ensembl chr 3:107,520,642...107,533,496 		JBrowse link
G EHMT1 euchromatic histone lysine methyltransferase 1 ISO RGD PMID:23200123 RGD:7242632
G EHMT2 euchromatic histone lysine methyltransferase 2 ISO RGD PMID:23200123 PMID:23642229 RGD:7242632 RGD:9479074 NCBI chr 7:23,977,683...23,992,673
Ensembl chr 7:23,977,683...23,993,478 		JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:23200123 RGD:7242632 NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941 		JBrowse link
G H2AX H2A.X variant histone ISO RGD PMID:24614311 RGD:9075965 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084 		JBrowse link
G H2AZ1 H2A.Z variant histone 1 ISO RGD PMID:24696452 RGD:9074213 NCBI chr 8:120,563,752...120,566,023
Ensembl chr 8:120,563,752...120,566,177 		JBrowse link
G H3-3A H3.3 histone A ISO RGD PMID:24614311 RGD:9075965 NCBI chr10:13,939,938...13,947,976
Ensembl chr10:13,923,077...13,948,484 		JBrowse link
G H3-3B H3.3 histone B ISO RGD PMID:24614311 RGD:9075965 NCBI chr12:5,632,326...5,634,977
Ensembl chr12:5,632,365...5,634,726 		JBrowse link
G HAT1 histone acetyltransferase 1 ISO RGD PMID:21151613 RGD:9104959 NCBI chr15:78,022,147...78,079,669
Ensembl chr15:78,022,207...78,079,608 		JBrowse link
G HCFC1 host cell factor C1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr  X:124,673,125...124,694,846
Ensembl chr  X:124,673,128...124,694,152 		JBrowse link
G HDAC1 histone deacetylase 1 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,411 		JBrowse link
G HDAC10 histone deacetylase 10 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 5:439,142...445,337
Ensembl chr 5:439,808...445,334 		JBrowse link
G HDAC11 histone deacetylase 11 ISO RGD PMID:21151613 RGD:9104959 NCBI chr13:70,860,650...70,879,863
Ensembl chr13:70,860,658...70,879,856 		JBrowse link
G HDAC2 histone deacetylase 2 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 1:79,867,713...79,901,597
Ensembl chr 1:79,863,094...79,901,585 		JBrowse link
G HDAC3 histone deacetylase 3 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 2:143,273,188...143,287,421
Ensembl chr 2:143,273,192...143,287,399 		JBrowse link
G HDAC4 histone deacetylase 4 ISO RGD PMID:21151613 RGD:9104959 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,635...138,614,301 		JBrowse link
G HDAC5 histone deacetylase 5 ISO RGD PMID:21151613 RGD:9104959 NCBI chr12:19,077,910...19,119,463
Ensembl chr12:19,078,005...19,121,154 		JBrowse link
G HDAC6 histone deacetylase 6 ISO RGD PMID:21151613 RGD:9104959 NCBI chr  X:42,917,911...42,941,894
Ensembl chr  X:42,917,964...42,941,887 		JBrowse link
G HDAC7 histone deacetylase 7 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 5:78,150,554...78,186,051
Ensembl chr 5:78,150,561...78,186,072 		JBrowse link
G HDAC8 histone deacetylase 8 ISO RGD PMID:21151613 RGD:9104959 NCBI chr  X:58,210,182...58,450,681
Ensembl chr  X:58,210,192...58,450,573 		JBrowse link
G HDAC9 histone deacetylase 9 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 9:87,164,400...88,192,803
Ensembl chr 9:87,449,359...88,186,961 		JBrowse link
G HIRA histone cell cycle regulator ISO RGD PMID:23288364 RGD:9068945 NCBI chr14:51,029,117...51,102,409
Ensembl chr14:51,029,126...51,102,409 		JBrowse link
G HJURP Holliday junction recognition protein ISO RGD PMID:23288364 RGD:9068945 NCBI chr15:134,106,561...134,123,163
Ensembl chr15:134,106,578...134,123,140 		JBrowse link
G ING2 inhibitor of growth family member 2 ISO RGD PMID:23642229 RGD:9479074 NCBI chr15:44,917,595...44,925,900
Ensembl chr15:44,918,066...44,925,867 		JBrowse link
G JMJD1C jumonji domain containing 1C ISO RGD PMID:23200123 RGD:7242632 NCBI chr14:66,640,845...66,966,911
Ensembl chr14:66,640,849...66,920,324 		JBrowse link
G KAT2A lysine acetyltransferase 2A ISO RGD PMID:21151613 PMID:23642229 RGD:9104959 RGD:9479074 NCBI chr12:20,638,493...20,647,464
Ensembl chr12:20,638,497...20,647,461 		JBrowse link
G KAT2B lysine acetyltransferase 2B ISO RGD PMID:21151613 RGD:9104959 NCBI chr13:6,985,151...7,099,771
Ensembl chr13:6,985,235...7,100,345 		JBrowse link
G KAT5 lysine acetyltransferase 5 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 2:6,560,544...6,572,461
Ensembl chr 2:6,560,513...6,572,466 		JBrowse link
G KAT6A lysine acetyltransferase 6A ISO RGD PMID:21151613 RGD:9104959 NCBI chr17:11,002,818...11,109,974 JBrowse link
G KAT6B lysine acetyltransferase 6B ISO RGD PMID:21151613 RGD:9104959 NCBI chr14:77,390,790...77,597,674
Ensembl chr14:77,404,136...77,597,673 		JBrowse link
G KAT7 lysine acetyltransferase 7 ISO RGD PMID:21151613 RGD:9104959 NCBI chr12:25,970,966...26,005,006
Ensembl chr12:25,970,962...26,008,302 		JBrowse link
G KAT8 lysine acetyltransferase 8 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 3:17,362,326...17,373,110
Ensembl chr 3:17,362,267...17,373,110 		JBrowse link
G KDM1A lysine demethylase 1A ISO RGD PMID:23200123 RGD:7242632 NCBI chr 6:80,903,407...80,971,875
Ensembl chr 6:80,903,424...80,971,873 		JBrowse link
G KDM1B lysine demethylase 1B ISO RGD PMID:23200123 RGD:7242632 NCBI chr 7:13,846,283...13,902,912
Ensembl chr 7:13,845,942...13,901,255 		JBrowse link
G KDM2A lysine demethylase 2A ISO RGD PMID:23200123 RGD:7242632 NCBI chr 2:5,238,690...5,357,799
Ensembl chr 2:5,240,312...5,357,829 		JBrowse link
G KDM2B lysine demethylase 2B ISO RGD PMID:23200123 RGD:7242632 NCBI chr14:31,057,121...31,203,093
Ensembl chr14:31,165,950...31,203,091 		JBrowse link
G KDM3A lysine demethylase 3A ISO RGD PMID:23200123 RGD:7242632 NCBI chr 3:58,300,109...58,355,000
Ensembl chr 3:58,302,949...58,354,945 		JBrowse link
G KDM3B lysine demethylase 3B ISO RGD PMID:23200123 RGD:7242632 NCBI chr 2:140,346,145...140,418,556
Ensembl chr 2:140,346,223...140,418,527 		JBrowse link
G KDM4A lysine demethylase 4A ISO RGD PMID:23200123 PMID:23642229 PMID:24035451 RGD:7242632 RGD:9479074 RGD:9479148 NCBI chr 6:167,597,954...167,642,381
Ensembl chr 6:167,597,956...167,642,333 		JBrowse link
G KDM4B lysine demethylase 4B ISO RGD PMID:23200123 RGD:7242632 NCBI chr 2:73,746,379...73,889,881
Ensembl chr 2:73,747,669...73,889,866 		JBrowse link
G KDM4C lysine demethylase 4C ISO RGD PMID:23200123 RGD:7242632 NCBI chr 1:215,071,335...215,507,778
Ensembl chr 1:215,071,419...215,507,800 		JBrowse link
G KDM5A lysine demethylase 5A ISO RGD PMID:23200123 RGD:7242632 NCBI chr 5:67,628,791...67,716,143
Ensembl chr 5:67,629,380...67,715,905 		JBrowse link
G KDM5B lysine demethylase 5B ISO RGD PMID:23200123 RGD:7242632 NCBI chr10:24,739,115...24,831,537
Ensembl chr10:24,736,838...24,831,447 		JBrowse link
G KDM5C lysine demethylase 5C ISO RGD PMID:23200123 RGD:7242632 NCBI chr  X:45,968,812...46,003,215
Ensembl chr  X:45,968,814...46,003,215 		JBrowse link
G KDM6A lysine demethylase 6A ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr  X:39,953,764...40,154,197
Ensembl chr  X:39,953,814...40,154,029 		JBrowse link
G KDM6B lysine demethylase 6B ISO RGD PMID:23200123 RGD:7242632 NCBI chr12:53,087,072...53,108,949
Ensembl chr12:53,098,964...53,108,214 		JBrowse link
G KDM7A lysine demethylase 7A ISO RGD PMID:23200123 RGD:7242632 NCBI chr18:9,581,468...9,664,750
Ensembl chr18:9,581,384...9,664,748 		JBrowse link
G KDM8 lysine demethylase 8 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 3:19,653,396...19,676,207
Ensembl chr 3:19,653,402...19,676,148 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr 9:45,743,566...45,828,559
Ensembl chr 9:45,743,397...45,824,884 		JBrowse link
G KMT2B lysine methyltransferase 2B ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr 6:45,146,863...45,166,854
Ensembl chr 6:45,147,566...45,166,852 		JBrowse link
G KMT2C lysine methyltransferase 2C ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr18:4,993,213...5,279,668
Ensembl chr18:4,993,227...5,278,723 		JBrowse link
G KMT2D lysine methyltransferase 2D ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr 5:15,049,827...15,091,622 JBrowse link
G KMT2E lysine methyltransferase 2E (inactive) ISO RGD PMID:23200123 RGD:7242632 NCBI chr 9:104,876,301...105,007,161
Ensembl chr 9:104,911,821...105,007,084 		JBrowse link
G KMT5A lysine methyltransferase 5A ISO RGD PMID:23200123 RGD:7242632 NCBI chr14:29,523,102...29,543,522
Ensembl chr14:29,523,105...29,543,493 		JBrowse link
G KMT5B lysine methyltransferase 5B ISO RGD PMID:23200123 RGD:7242632 NCBI chr 2:4,710,510...4,768,237
Ensembl chr 2:4,711,023...4,765,979 		JBrowse link
G KMT5C lysine methyltransferase 5C ISO RGD PMID:23200123 RGD:7242632 NCBI chr 6:59,517,058...59,524,551
Ensembl chr 6:59,517,098...59,524,550 		JBrowse link
G L3MBTL1 L3MBTL histone methyl-lysine binding protein 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr17:46,135,567...46,176,967
Ensembl chr17:46,136,013...46,173,944 		JBrowse link
G LBR lamin B receptor ISO RGD PMID:24035451 RGD:9479148 NCBI chr10:13,389,896...13,416,831
Ensembl chr10:13,386,946...13,416,759 		JBrowse link
G LOC100627380 lysine-specific demethylase 4D-like ISO RGD PMID:23200123 RGD:7242632 NCBI chr 9:27,083,348...27,085,693 JBrowse link
G LOC110257883 lysine-specific demethylase 5D-like ISO RGD PMID:23200123 RGD:7242632 NCBI chr  Y:39,582,253...39,631,823
Ensembl chr  Y:39,582,815...39,631,815 		JBrowse link
G MACROH2A1 macroH2A.1 histone ISO RGD PMID:24696452 RGD:9074213 NCBI chr 2:137,535,128...137,623,886
Ensembl chr 2:137,534,138...137,623,886 		JBrowse link
G MACROH2A2 macroH2A.2 histone ISO RGD PMID:24696452 RGD:9074213 NCBI chr14:73,002,385...73,055,228
Ensembl chr14:73,003,117...73,055,229 		JBrowse link
G MCPH1 microcephalin 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr15:37,455,186...37,674,971
Ensembl chr15:37,455,551...37,673,633 		JBrowse link
G MDC1 mediator of DNA damage checkpoint 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 7:23,229,508...23,247,739
Ensembl chr 7:23,229,510...23,245,575 		JBrowse link
G MEN1 menin 1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr 2:7,358,130...7,364,952
Ensembl chr 2:7,358,218...7,364,952 		JBrowse link
G MYSM1 Myb like, SWIRM and MPN domains 1 ISO RGD PMID:24647359 RGD:9479061 NCBI chr 6:153,755,209...153,798,412
Ensembl chr 6:153,756,182...153,795,535 		JBrowse link
G NAP1L1 nucleosome assembly protein 1 like 1 ISO RGD PMID:23288364 RGD:9068945 NCBI chr 5:39,329,628...39,363,699
Ensembl chr 5:39,328,052...39,363,711 		JBrowse link
G NASP nuclear autoantigenic sperm protein ISO RGD PMID:23288364 RGD:9068945 NCBI chr 6:165,773,964...165,804,978
Ensembl chr 6:165,770,055...165,805,383 		JBrowse link
G NCOA6 nuclear receptor coactivator 6 ISO RGD PMID:22663077 RGD:9479053 NCBI chr17:38,114,284...38,221,904
Ensembl chr17:38,114,291...38,221,901 		JBrowse link
G NSD1 nuclear receptor binding SET domain protein 1 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 2:80,649,882...80,810,934
Ensembl chr 2:80,654,379...80,809,059 		JBrowse link
G NSD3 nuclear receptor binding SET domain protein 3 ISO RGD PMID:23200123 RGD:7242632 NCBI chr15:48,119,132...48,245,673
Ensembl chr15:48,136,363...48,241,815 		JBrowse link
G ORC1 origin recognition complex subunit 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 6:159,819,302...159,852,306
Ensembl chr 6:159,819,339...159,852,305 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr 3:18,052,679...18,056,920
Ensembl chr 3:18,052,935...18,056,837 		JBrowse link
G PAXIP1 PAX interacting protein 1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr18:3,066,853...3,111,239
Ensembl chr18:3,066,848...3,111,240 		JBrowse link
G PBRM1 polybromo 1 ISO RGD PMID:24686119 RGD:9479075 NCBI chr13:34,689,718...34,821,117
Ensembl chr13:34,689,726...34,820,952 		JBrowse link
G PCGF1 polycomb group ring finger 1 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 3:68,540,674...68,543,271 JBrowse link
G PCGF2 polycomb group ring finger 2 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr12:23,362,631...23,375,779
Ensembl chr12:23,362,654...23,375,775 		JBrowse link
G PCGF3 polycomb group ring finger 3 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 8:140,435...189,796
Ensembl chr 8:140,446...182,261 		JBrowse link
G PCGF5 polycomb group ring finger 5 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr14:102,827,140...102,961,862
Ensembl chr14:102,636,838...102,961,860 		JBrowse link
G PCGF6 polycomb group ring finger 6 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr14:114,062,457...114,287,458
Ensembl chr14:114,249,820...114,287,434 		JBrowse link
G PHC1 polyhomeotic homolog 1 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 5:62,557,774...62,580,640
Ensembl chr 5:62,557,776...62,580,651 		JBrowse link
G PHC2 polyhomeotic homolog 2 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 6:89,574,030...89,685,275
Ensembl chr 6:89,574,035...89,685,272 		JBrowse link
G PHC3 polyhomeotic homolog 3 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr13:108,791,675...108,883,620
Ensembl chr13:108,776,220...108,883,572 		JBrowse link
G PHF1 PHD finger protein 1 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr 7:29,714,295...29,719,996
Ensembl chr 7:29,714,293...29,719,987 		JBrowse link
G PHF19 PHD finger protein 19 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr 1:260,899,462...260,919,776
Ensembl chr 1:260,899,452...260,920,110 		JBrowse link
G PHF2 PHD finger protein 2 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 3:42,988,607...43,078,811
Ensembl chr 3:42,988,636...43,078,808 		JBrowse link
G PHF8 PHD finger protein 8 ISO RGD PMID:23200123 RGD:7242632 NCBI chr  X:46,648,164...46,761,192
Ensembl chr  X:46,648,168...46,759,239 		JBrowse link
G PRDM16 PR/SET domain 16 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 6:64,704,181...65,012,580
Ensembl chr 6:64,704,920...65,012,570 		JBrowse link
G PRDM2 PR/SET domain 2 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 6:73,135,872...73,240,271
Ensembl chr 6:73,118,177...73,239,423 		JBrowse link
G PRDM6 PR/SET domain 6 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 2:126,605,416...126,712,463
Ensembl chr 2:126,606,171...126,712,494 		JBrowse link
G PRDM8 PR/SET domain 8 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 8:137,604,805...137,611,389
Ensembl chr 8:137,605,600...137,612,651 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 6:54,718,845...54,730,411
Ensembl chr 6:54,714,157...54,732,574 		JBrowse link
G PRMT2 protein arginine methyltransferase 2 ISO RGD PMID:24583552 RGD:9479047
G PRMT5 protein arginine methyltransferase 5 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 7:76,110,956...76,119,619
Ensembl chr 7:76,110,951...76,124,989 		JBrowse link
G PRMT6 protein arginine methyltransferase 6 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 4:112,698,865...112,710,305
Ensembl chr 4:112,701,088...112,703,581 		JBrowse link
G PRMT7 protein arginine methyltransferase 7 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 6:28,883,148...28,945,904
Ensembl chr 6:28,883,646...28,945,905 		JBrowse link
G RAG2 recombination activating 2 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 2:24,547,605...24,553,944
Ensembl chr 2:24,547,644...24,558,403 		JBrowse link
G RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit ISO RGD PMID:22663077 RGD:9479053 NCBI chr 9:65,783,725...65,821,681
Ensembl chr 9:65,783,736...65,821,650 		JBrowse link
G RING1 ring finger protein 1 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 7:25,251,507...25,255,526
Ensembl chr 7:25,251,486...25,255,522 		JBrowse link
G RNF2 ring finger protein 2 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 9:126,172,637...126,284,567
Ensembl chr 9:126,172,301...126,287,603 		JBrowse link
G SETD1A SET domain containing 1A, histone lysine methyltransferase ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr 3:17,463,768...17,490,397
Ensembl chr 3:17,463,775...17,488,594 		JBrowse link
G SETD1B SET domain containing 1B, histone lysine methyltransferase ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr14:30,862,155...30,885,592
Ensembl chr14:30,862,158...30,885,260 		JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr13:29,884,708...29,996,285
Ensembl chr13:29,884,719...29,996,359 		JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr 8:87,478,266...87,527,190
Ensembl chr 8:87,478,173...87,527,188 		JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 4:98,259,801...98,293,238
Ensembl chr 4:98,260,375...98,293,097 		JBrowse link
G SGF29 SAGA complex associated factor 29 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr 3:18,354,798...18,387,930
Ensembl chr 3:18,354,799...18,387,856 		JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:21151613 RGD:9104959 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
G SIRT2 sirtuin 2 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 6:47,682,427...47,703,408
Ensembl chr 6:47,682,429...47,703,384 		JBrowse link
G SIRT3 sirtuin 3 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 2:38,465...55,074
Ensembl chr 2:38,464...55,101 		JBrowse link
G SIRT4 sirtuin 4 ISO RGD PMID:21151613 RGD:9104959 NCBI chr14:40,290,288...40,303,887
Ensembl chr14:40,290,288...40,303,879 		JBrowse link
G SIRT5 sirtuin 5 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 7:9,951,024...9,968,004
Ensembl chr 7:9,951,030...9,968,448 		JBrowse link
G SIRT6 sirtuin 6 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 2:74,568,539...74,577,774
Ensembl chr 2:74,568,493...74,577,772 		JBrowse link
G SIRT7 sirtuin 7 ISO RGD PMID:21151613 RGD:9104959 NCBI chr12:1,078,155...1,084,112
Ensembl chr12:1,078,166...1,084,119 		JBrowse link
G SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 1:219,624,773...219,815,438
Ensembl chr 1:219,573,535...219,815,421 		JBrowse link
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 2:69,717,175...69,810,301
Ensembl chr 2:69,662,238...69,810,295 		JBrowse link
G SMYD1 SET and MYND domain containing 1 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 3:57,866,078...57,918,576
Ensembl chr 3:57,867,250...57,918,568 		JBrowse link
G SMYD2 SET and MYND domain containing 2 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 9:129,263,524...129,316,226
Ensembl chr 9:129,263,526...129,316,349 		JBrowse link
G SMYD3 SET and MYND domain containing 3 ISO RGD PMID:23200123 RGD:7242632 NCBI chr10:18,267,598...19,019,520
Ensembl chr10:18,267,189...19,019,642 		JBrowse link
G SPIN1 spindlin 1 ISO RGD PMID:24035451 RGD:9479148 NCBI chr14:227,219...291,420
Ensembl chr14:227,209...294,826 		JBrowse link
G SSRP1 structure specific recognition protein 1 ISO RGD PMID:23288364 RGD:9068945 NCBI chr 2:13,619,666...13,629,233
Ensembl chr 2:13,619,716...13,629,227 		JBrowse link
G SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit ISO RGD PMID:23288364 RGD:9068945 NCBI chr 7:77,780,968...77,814,519
Ensembl chr 7:77,781,316...77,814,505 		JBrowse link
G SUV39H1 SUV39H1 histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr  X:42,797,309...42,811,457
Ensembl chr  X:42,797,828...42,811,461 		JBrowse link
G SUV39H2 SUV39H2 histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr10:46,874,606...46,900,058
Ensembl chr10:46,873,126...46,900,040 		JBrowse link
G TAF1 TATA-box binding protein associated factor 1 ISO RGD PMID:23642229 PMID:24686119 RGD:9479074 RGD:9479075 NCBI chr  X:57,382,211...57,466,700
Ensembl chr  X:57,382,354...57,466,697 		JBrowse link
G TDRD3 tudor domain containing 3 ISO RGD PMID:23211769 PMID:24035451 RGD:9479148 RGD:9479163 NCBI chr11:33,257,556...33,440,131
Ensembl chr11:33,258,063...33,440,123 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr 1:127,958,500...128,032,370
Ensembl chr 1:127,959,213...128,028,712 		JBrowse link
G TRIM24 tripartite motif containing 24 ISO RGD PMID:23642229 RGD:9479074 NCBI chr18:11,055,211...11,151,755
Ensembl chr18:11,055,213...11,151,404 		JBrowse link
G TRIM33 tripartite motif containing 33 ISO RGD PMID:23642229 PMID:24686119 RGD:9479074 RGD:9479075 NCBI chr 4:106,058,197...106,195,145
Ensembl chr 4:106,058,109...106,191,800 		JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr 2:73,898,061...73,937,727
Ensembl chr 2:73,898,071...73,931,769 		JBrowse link
G USP12 ubiquitin specific peptidase 12 ISO RGD PMID:24647359 RGD:9479061 NCBI chr11:4,612,274...4,689,791
Ensembl chr11:4,612,277...4,689,432 		JBrowse link
G USP16 ubiquitin specific peptidase 16 ISO RGD PMID:24647359 RGD:9479061 NCBI chr13:192,376,850...192,406,474
Ensembl chr13:192,376,881...192,406,468 		JBrowse link
G USP21 ubiquitin specific peptidase 21 ISO RGD PMID:24647359 RGD:9479061 NCBI chr 4:89,289,056...89,295,232
Ensembl chr 4:89,289,070...89,295,237 		JBrowse link
G USP22 ubiquitin specific peptidase 22 ISO RGD PMID:24647359 RGD:9479061 NCBI chr12:61,273,939...61,308,381
Ensembl chr12:61,271,641...61,308,270 		JBrowse link
G USP3 ubiquitin specific peptidase 3 ISO RGD PMID:24647359 RGD:9479061 NCBI chr 1:108,414,358...108,515,611
Ensembl chr 1:108,415,703...108,515,447 		JBrowse link
G USP44 ubiquitin specific peptidase 44 ISO RGD PMID:24647359 RGD:9479061 NCBI chr 5:87,864,410...87,890,913
Ensembl chr 5:87,875,851...87,889,680 		JBrowse link
G WDR5 WD repeat domain 5 ISO RGD PMID:22663077 PMID:23642229 RGD:9479053 RGD:9479074 NCBI chr 1:273,560,274...273,577,827
Ensembl chr 1:273,560,283...273,578,063 		JBrowse link
G WDR82 WD repeat domain 82 ISO RGD PMID:22663077 RGD:9479053 NCBI chr13:34,387,799...34,412,190
Ensembl chr13:34,387,808...34,412,140 		JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO RGD PMID:23642229 RGD:9479074 NCBI chr 4:35,975,513...36,009,909
Ensembl chr 4:35,975,508...36,009,887 		JBrowse link
homocysteine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase ISO RGD PMID:11741948 PMID:20814827 RGD:7242426 RGD:730275 NCBI chr17:37,726,084...37,744,378
Ensembl chr17:37,726,084...37,744,461 		JBrowse link
G AS3MT arsenite methyltransferase ISO RGD PMID:11790780 RGD:625365 NCBI chr14:113,844,107...113,867,880
Ensembl chr14:113,847,859...113,869,507 		JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 ISO RGD PMID:15866169 RGD:1359044 NCBI chr 2:69,602,121...69,644,862
Ensembl chr 2:69,602,136...69,644,854 		JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:12584150 RGD:1359089 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO RGD PMID:12473678 RGD:1359078 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844 		JBrowse link
G GAMT guanidinoacetate N-methyltransferase ISO RGD PMID:15533043 RGD:1359081 NCBI chr 2:77,076,566...77,079,751
Ensembl chr 2:77,076,566...77,079,759 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:15347642 RGD:1359070 NCBI chr 7:38,038,359...38,041,218
Ensembl chr 7:38,038,358...38,041,217 		JBrowse link
G HNMT histamine N-methyltransferase ISO RGD PMID:11566133 RGD:1359041 NCBI chr15:13,733,412...13,768,106
Ensembl chr15:13,732,680...13,768,199 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G NNMT nicotinamide N-methyltransferase ISO RGD PMID:15922112 RGD:1359084 NCBI chr 9:41,871,072...41,882,415
Ensembl chr 9:41,870,980...41,882,756 		JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO RGD PMID:8263531 RGD:729481 NCBI chr 1:16,202,859...16,249,879
Ensembl chr 1:16,198,223...16,249,531 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO RGD PMID:8344945 RGD:729486 NCBI chr12:60,880,367...60,919,279 JBrowse link
G PNMT phenylethanolamine N-methyltransferase ISO RGD PMID:12438084 RGD:1359087 NCBI chr12:22,648,396...22,651,520
Ensembl chr12:22,648,398...22,649,999 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 ISO RGD PMID:15866169 RGD:1359044 NCBI chr 6:54,718,845...54,730,411
Ensembl chr 6:54,714,157...54,732,574 		JBrowse link
G PRMT5 protein arginine methyltransferase 5 ISO RGD PMID:15866169 RGD:1359044 NCBI chr 7:76,110,956...76,119,619
Ensembl chr 7:76,110,951...76,124,989 		JBrowse link
G PRMT6 protein arginine methyltransferase 6 ISO RGD PMID:15866169 RGD:1359044 NCBI chr 4:112,698,865...112,710,305
Ensembl chr 4:112,701,088...112,703,581 		JBrowse link
G RNMT RNA guanine-7 methyltransferase ISO RGD PMID:11472630 RGD:1359071 NCBI chr 6:96,338,283...96,362,814
Ensembl chr 6:96,338,288...96,360,169 		JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 ISO RGD PMID:11959841 RGD:1359072 NCBI chr 4:98,259,801...98,293,238
Ensembl chr 4:98,260,375...98,293,097 		JBrowse link
methionine cycle/metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase ISO SMPDB
RGD		 PMID:2292587 PMID:11741948 PMID:23073625 RGD:7242425 RGD:7242932 RGD:730275 SMP:00033 NCBI chr17:37,726,084...37,744,378
Ensembl chr17:37,726,084...37,744,461 		JBrowse link
G AMD1 adenosylmethionine decarboxylase 1 ISO SMPDB
RGD		 PMID:2292587 PMID:23073625 RGD:7242425 RGD:7242932 SMP:00033 NCBI chr 1:76,839,448...76,863,745
Ensembl chr 1:76,839,731...76,863,738 		JBrowse link
G AS3MT arsenite methyltransferase ISO RGD PMID:11790780 RGD:625365 NCBI chr14:113,844,107...113,867,880
Ensembl chr14:113,847,859...113,869,507 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase ISO SMPDB
RGD		 PMID:15845641 PMID:23073625 RGD:1359026 RGD:7242425 SMP:00033 NCBI chr 2:87,911,093...87,935,252
Ensembl chr 2:87,910,603...87,935,252 		JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044 RGD:7242552 NCBI chr 2:69,602,121...69,644,862
Ensembl chr 2:69,602,136...69,644,854 		JBrowse link
G CBS cystathionine beta-synthase ISO SMPDB SMP:00033 NCBI chr13:206,205,942...206,231,363
Ensembl chr13:206,205,946...206,230,248 		JBrowse link
G CHDH choline dehydrogenase ISO SMPDB SMP:00033 NCBI chr13:35,910,688...35,950,438
Ensembl chr13:35,910,698...35,948,683 		JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:12584150 RGD:1359089 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
G CTH cystathionine gamma-lyase ISO SMPDB SMP:00033 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,454,914...142,486,367 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO SMPDB
RGD		 PMID:12473678 PMID:22342103 RGD:1359078 RGD:7242551 SMP:00033 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO RGD PMID:22342103 RGD:7242551 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO RGD PMID:22342103 RGD:7242551 NCBI chr17:36,345,715...36,386,076
Ensembl chr17:36,345,816...36,386,072 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase ISO RGD PMID:12628190 PMID:22194015 RGD:1359080 RGD:7242554 NCBI chr 2:76,339,452...76,401,974
Ensembl chr 2:76,339,470...76,401,965 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:22194015 RGD:7242554 NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941 		JBrowse link
G GAMT guanidinoacetate N-methyltransferase ISO RGD PMID:15533043 RGD:1359081 NCBI chr 2:77,076,566...77,079,751
Ensembl chr 2:77,076,566...77,079,759 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:15347642 PMID:22342103 PMID:23073625 RGD:1359070 RGD:7242425 RGD:7242551 NCBI chr 7:38,038,359...38,041,218
Ensembl chr 7:38,038,358...38,041,217 		JBrowse link
G HNMT histamine N-methyltransferase ISO RGD PMID:11566133 RGD:1359041 NCBI chr15:13,733,412...13,768,106
Ensembl chr15:13,732,680...13,768,199 		JBrowse link
G IL4I1 interleukin 4 induced 1 ISO SMPDB SMP:00033 NCBI chr 6:54,906,401...54,945,840
Ensembl chr 6:54,906,406...54,916,081 		JBrowse link
G KMT5A lysine methyltransferase 5A ISO RGD PMID:22194015 RGD:7242554 NCBI chr14:29,523,102...29,543,522
Ensembl chr14:29,523,105...29,543,493 		JBrowse link
G LOC110258194 acetylserotonin O-methyltransferase-like ISO RGD PMID:12198599 RGD:1359073
G MARS1 methionyl-tRNA synthetase 1 ISO SMPDB SMP:00033 NCBI chr 5:22,752,405...22,785,509
Ensembl chr 5:22,752,374...22,785,501 		JBrowse link
G MAT1A methionine adenosyltransferase 1A ISO RGD PMID:2292587 PMID:9202427 PMID:23073625 RGD:1359039 RGD:7242425 RGD:7242932 NCBI chr14:82,109,405...82,126,487
Ensembl chr14:82,107,390...82,127,049 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO SMPDB
RGD		 PMID:11099469 PMID:23073625 RGD:1359040 RGD:7242425 SMP:00033 NCBI chr 3:59,220,203...59,225,097
Ensembl chr 3:59,218,688...59,225,249 		JBrowse link
G MAT2B methionine adenosyltransferase 2B ISO SMPDB
RGD		 PMID:23073625 RGD:7242425 SMP:00033 NCBI chr16:60,255,541...60,274,228
Ensembl chr16:60,255,358...60,274,135 		JBrowse link
G MRM2 mitochondrial rRNA methyltransferase 2 ISO RGD PMID:11827451 RGD:1359074 NCBI chr 3:1,560,161...1,567,351
Ensembl chr 3:1,560,167...1,567,379 		JBrowse link
G MSRB2 methionine sulfoxide reductase B2 ISO SMPDB SMP:00033 NCBI chr10:51,888,828...51,910,725
Ensembl chr10:51,889,208...51,910,392 		JBrowse link
G MSRB3 methionine sulfoxide reductase B3 ISO SMPDB SMP:00033 NCBI chr 5:29,695,824...29,863,601
Ensembl chr 5:29,695,640...29,863,599 		JBrowse link
G MTAP methylthioadenosine phosphorylase ISO SMPDB
RGD		 PMID:2292587 RGD:7242932 SMP:00033 NCBI chr 1:200,882,954...200,934,389
Ensembl chr 1:200,882,956...200,934,445 		JBrowse link
G MTFMT mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00033 NCBI chr 1:106,970,620...107,001,563
Ensembl chr 1:106,970,640...107,001,564 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO SMPDB
RGD		 PMID:11933257 RGD:1535021 SMP:00033 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO SMPDB
RGD		 PMID:15845641 PMID:20814827 PMID:23073625 RGD:1359026 RGD:7242425 RGD:7242426 SMP:00033 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 PMID:20814827 RGD:1359037 RGD:7242426 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783 		JBrowse link
G NNMT nicotinamide N-methyltransferase ISO RGD PMID:15922112 RGD:1359084 NCBI chr 9:41,871,072...41,882,415
Ensembl chr 9:41,870,980...41,882,756 		JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO RGD PMID:8263531 RGD:729481 NCBI chr 1:16,202,859...16,249,879
Ensembl chr 1:16,198,223...16,249,531 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO RGD PMID:8344945 RGD:729486 NCBI chr12:60,880,367...60,919,279 JBrowse link
G PNMT phenylethanolamine N-methyltransferase ISO RGD PMID:12438084 RGD:1359087 NCBI chr12:22,648,396...22,651,520
Ensembl chr12:22,648,398...22,649,999 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044 RGD:7242552 NCBI chr 6:54,718,845...54,730,411
Ensembl chr 6:54,714,157...54,732,574 		JBrowse link
G PRMT2 protein arginine methyltransferase 2 ISO RGD PMID:21074527 RGD:7242552
G PRMT3 protein arginine methyltransferase 3 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 2:38,884,311...39,032,944
Ensembl chr 2:38,884,362...39,032,996 		JBrowse link
G PRMT5 protein arginine methyltransferase 5 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044 RGD:7242552 NCBI chr 7:76,110,956...76,119,619
Ensembl chr 7:76,110,951...76,124,989 		JBrowse link
G PRMT6 protein arginine methyltransferase 6 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044 RGD:7242552 NCBI chr 4:112,698,865...112,710,305
Ensembl chr 4:112,701,088...112,703,581 		JBrowse link
G PRMT7 protein arginine methyltransferase 7 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 6:28,883,148...28,945,904
Ensembl chr 6:28,883,646...28,945,905 		JBrowse link
G RNMT RNA guanine-7 methyltransferase ISO RGD PMID:11472630 RGD:1359071 NCBI chr 6:96,338,283...96,362,814
Ensembl chr 6:96,338,288...96,360,169 		JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr 8:87,478,266...87,527,190
Ensembl chr 8:87,478,173...87,527,188 		JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 ISO RGD PMID:11959841 RGD:1359072 NCBI chr 4:98,259,801...98,293,238
Ensembl chr 4:98,260,375...98,293,097 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO SMPDB SMP:00033 NCBI chr12:60,414,421...60,435,451
Ensembl chr12:60,416,463...60,435,450 		JBrowse link
G SMS spermine synthase ISO RGD PMID:23073625 RGD:7242425 NCBI chr  X:18,118,332...18,169,396
Ensembl chr  X:18,118,256...18,169,390 		JBrowse link
G SMYD2 SET and MYND domain containing 2 ISO RGD PMID:22194015 RGD:7242554 NCBI chr 9:129,263,524...129,316,226
Ensembl chr 9:129,263,526...129,316,349 		JBrowse link
G SRM spermidine synthase ISO SMPDB
RGD		 PMID:23073625 RGD:7242425 SMP:00033 NCBI chr 6:71,246,895...71,253,534
Ensembl chr 6:71,246,876...71,253,508 		JBrowse link
G SUV39H1 SUV39H1 histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr  X:42,797,309...42,811,457
Ensembl chr  X:42,797,828...42,811,461 		JBrowse link
G SUV39H2 SUV39H2 histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr10:46,874,606...46,900,058
Ensembl chr10:46,873,126...46,900,040 		JBrowse link
polyamine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD PMID:10430362 PMID:13678416 RGD:1578320 RGD:7244193 NCBI chr 1:76,839,448...76,863,745
Ensembl chr 1:76,839,731...76,863,738 		JBrowse link
G AZIN1 antizyme inhibitor 1 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 4:34,221,368...34,257,261
Ensembl chr 4:34,234,679...34,257,134 		JBrowse link
G OAZ1 ornithine decarboxylase antizyme 1 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 2:76,293,142...76,296,626
Ensembl chr 2:76,293,150...76,296,620 		JBrowse link
G OAZ2 ornithine decarboxylase antizyme 2 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 1:107,325,225...107,338,475
Ensembl chr 1:107,325,191...107,339,309 		JBrowse link
G OAZ3 ornithine decarboxylase antizyme 3 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 4:97,439,993...97,448,493
Ensembl chr 4:97,439,993...97,448,493 		JBrowse link
G ODC1 ornithine decarboxylase 1 ISO RGD PMID:10430362 PMID:13678416 RGD:1578320 RGD:7244193 NCBI chr 3:126,087,013...126,095,644
Ensembl chr 3:126,087,242...126,096,051 		JBrowse link
G PAOX polyamine oxidase ISO RGD PMID:13678416 PMID:15541750 RGD:7244190 RGD:7244193 NCBI chr14:141,360,509...141,369,642
Ensembl chr14:141,360,608...141,369,641 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:13678416 PMID:15541750 RGD:7244190 RGD:7244193 NCBI chr  X:19,908,037...19,910,553
Ensembl chr  X:19,907,906...19,910,974 		JBrowse link
G SMOX spermine oxidase ISO RGD PMID:13678416 PMID:15541750 RGD:7244190 RGD:7244193 NCBI chr17:31,552,927...31,592,007
Ensembl chr17:31,548,636...31,591,975 		JBrowse link
G SMS spermine synthase ISO RGD PMID:13678416 RGD:7244193 NCBI chr  X:18,118,332...18,169,396
Ensembl chr  X:18,118,256...18,169,390 		JBrowse link
G SRM spermidine synthase ISO RGD PMID:13678416 RGD:7244193 NCBI chr 6:71,246,895...71,253,534
Ensembl chr 6:71,246,876...71,253,508 		JBrowse link
putrescine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD PMID:10430362 RGD:1578320 NCBI chr 1:76,839,448...76,863,745
Ensembl chr 1:76,839,731...76,863,738 		JBrowse link
G ODC1 ornithine decarboxylase 1 ISO RGD PMID:10430362 RGD:1578320 NCBI chr 3:126,087,013...126,095,644
Ensembl chr 3:126,087,242...126,096,051 		JBrowse link
remethylation pathway of homocysteine metabolism - cobalamin dependent term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 PMID:20814827 RGD:1359026 RGD:7242426 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 PMID:20814827 RGD:1359037 RGD:7242426 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783 		JBrowse link
remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependent term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase ISO SMPDB SMP:00123 NCBI chr17:37,726,084...37,744,378
Ensembl chr17:37,726,084...37,744,461 		JBrowse link
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 ISO SMPDB SMP:00123 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase ISO RGD
SMPDB		 PMID:15845641 PMID:20346934 PMID:20814827 RGD:1359026 RGD:7242426 RGD:7242428 SMP:00123 NCBI chr 2:87,911,093...87,935,252
Ensembl chr 2:87,910,603...87,935,252 		JBrowse link
G CHDH choline dehydrogenase ISO SMPDB SMP:00123 NCBI chr13:35,910,688...35,950,438
Ensembl chr13:35,910,698...35,948,683 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO SMPDB SMP:00123 NCBI chr 3:59,220,203...59,225,097
Ensembl chr 3:59,218,688...59,225,249 		JBrowse link
G MAT2B methionine adenosyltransferase 2B ISO SMPDB SMP:00123 NCBI chr16:60,255,541...60,274,228
Ensembl chr16:60,255,358...60,274,135 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO SMPDB SMP:00123 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO SMPDB SMP:00123 NCBI chr12:60,880,367...60,919,279 JBrowse link
spermidine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD
SMPDB		 PMID:1415709 PMID:10430362 PMID:10712236 RGD:1578320 RGD:7242911 RGD:7242912 SMP:00445 NCBI chr 1:76,839,448...76,863,745
Ensembl chr 1:76,839,731...76,863,738 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr 3:59,220,203...59,225,097
Ensembl chr 3:59,218,688...59,225,249 		JBrowse link
G MAT2B methionine adenosyltransferase 2B ISO SMPDB SMP:00445 NCBI chr16:60,255,541...60,274,228
Ensembl chr16:60,255,358...60,274,135 		JBrowse link
G ODC1 ornithine decarboxylase 1 ISO RGD
SMPDB		 PMID:1415709 PMID:2292587 PMID:10430362 RGD:1578320 RGD:7242912 RGD:7242932 SMP:00445 NCBI chr 3:126,087,013...126,095,644
Ensembl chr 3:126,087,242...126,096,051 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:2292587 RGD:7242932 NCBI chr  X:19,908,037...19,910,553
Ensembl chr  X:19,907,906...19,910,974 		JBrowse link
G SMS spermine synthase ISO SMPDB SMP:00445 NCBI chr  X:18,118,332...18,169,396
Ensembl chr  X:18,118,256...18,169,390 		JBrowse link
G SRM spermidine synthase ISO RGD
SMPDB		 PMID:2292587 PMID:16931179 PMID:23073625 RGD:7242425 RGD:7242920 RGD:7242932 SMP:00445 NCBI chr 6:71,246,895...71,253,534
Ensembl chr 6:71,246,876...71,253,508 		JBrowse link
spermine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD
SMPDB		 PMID:1415709 PMID:10430362 PMID:10712236 RGD:1578320 RGD:7242911 RGD:7242912 SMP:00445 NCBI chr 1:76,839,448...76,863,745
Ensembl chr 1:76,839,731...76,863,738 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr 3:59,220,203...59,225,097
Ensembl chr 3:59,218,688...59,225,249 		JBrowse link
G MAT2B methionine adenosyltransferase 2B ISO SMPDB SMP:00445 NCBI chr16:60,255,541...60,274,228
Ensembl chr16:60,255,358...60,274,135 		JBrowse link
G ODC1 ornithine decarboxylase 1 ISO SMPDB
RGD		 PMID:1415709 PMID:2292587 PMID:10430362 RGD:1578320 RGD:7242912 RGD:7242932 SMP:00445 NCBI chr 3:126,087,013...126,095,644
Ensembl chr 3:126,087,242...126,096,051 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:2292587 RGD:7242932 NCBI chr  X:19,908,037...19,910,553
Ensembl chr  X:19,907,906...19,910,974 		JBrowse link
G SMS spermine synthase ISO RGD
SMPDB		 PMID:2292587 PMID:23073625 RGD:7242425 RGD:7242932 SMP:00445 NCBI chr  X:18,118,332...18,169,396
Ensembl chr  X:18,118,256...18,169,390 		JBrowse link
G SRM spermidine synthase ISO SMPDB SMP:00445 NCBI chr 6:71,246,895...71,253,534
Ensembl chr 6:71,246,876...71,253,508 		JBrowse link
transsulfuration pathway of homocysteine metabolism term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBS cystathionine beta-synthase ISO SMPDB
RGD		 PMID:20162368 RGD:7242427 SMP:00455 NCBI chr13:206,205,942...206,231,363
Ensembl chr13:206,205,946...206,230,248 		JBrowse link
G CDO1 cysteine dioxygenase type 1 ISO RGD PMID:20162368 RGD:7242427 NCBI chr 2:119,927,768...119,940,690
Ensembl chr 2:119,927,772...119,940,665 		JBrowse link
G CSAD cysteine sulfinic acid decarboxylase ISO RGD PMID:20162368 RGD:7242427 NCBI chr 5:18,379,340...18,410,446
Ensembl chr 5:18,379,288...18,410,646 		JBrowse link
G CTH cystathionine gamma-lyase ISO SMPDB
RGD		 PMID:20162368 RGD:7242427 SMP:00455 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,454,914...142,486,367 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4041
    regulatory pathway 2489
      homeostasis pathway 1301
        organic chemical homeostasis pathway 363
          S-adenosylmethionine homeostasis pathway 264
            DNA modification pathway + 28
            folate metabolic pathway + 32
            histone modification pathway + 171
            homocysteine metabolic pathway + 29
            methionine cycle/metabolic pathway + 51
            polyamine metabolic pathway + 13
            radical SAM enzyme mediated metabolic pathway + 0
paths to the root