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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:S-adenosylmethionine homeostasis pathway
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Accession:PW:0001693 term browser browse the term
Definition:Those pathways that involve the balanced generation and utilization of S-adenosylmethionine (AdoMet or SAM). SAM is a universal methyl donor and at the cross roads of metabolism, gene expression regulation and cellular signaling.
Synonyms:related_synonym: AdoMet homeostasis pathway;   SAM homeostasis pathway

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altered DNA modification pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MBD4 methyl-CpG binding domain 4, DNA glycosylase ISO in silico assessment of loss of DNA-protein interactions and observed enhancement of DNA repair capacity (DRC) in the context of nucleotide excision repair (NER) pathway for SNP RGD PMID:24004570 RGD:9588971 NCBI chr22:51,616,840...51,626,232
Ensembl chr22:51,616,803...51,626,224 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr22:54,848,868...54,933,415
Ensembl chr22:54,848,901...54,934,629 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 4:74,787,292...74,811,196
Ensembl chr 4:74,787,629...74,810,960 		JBrowse link
G FOLR1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:63,405,513...63,413,372
Ensembl chr 1:63,406,597...63,413,352 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 4:7,461,521...7,493,032
Ensembl chr 4:7,461,526...7,493,840 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr16:22,164,661...22,173,376
Ensembl chr16:22,166,318...22,173,240 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
DNA modification pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXXC1 CXXC finger protein 1 ISO RGD PMID:23697932 RGD:9479164 NCBI chr18:30,668,879...30,674,841
Ensembl chr18:30,668,821...30,675,301 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr14:82,313,414...82,427,170
Ensembl chr14:82,402,826...82,420,819 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr 2:37,128,635...37,176,033
Ensembl chr 2:37,146,538...37,174,570 		JBrowse link
G EBF1 EBF transcription factor 1 ISO RGD PMID:24825349 RGD:8695944 NCBI chr23:61,097,268...61,502,784
Ensembl chr23:61,109,331...61,243,631 		JBrowse link
G KDM2A lysine demethylase 2A ISO RGD PMID:23697932 RGD:9479164 NCBI chr 1:7,004,109...7,152,072
Ensembl chr 1:7,003,784...7,082,720 		JBrowse link
G KDM2B lysine demethylase 2B ISO RGD PMID:23697932 RGD:9479164 NCBI chr11:116,805,541...116,957,236
Ensembl chr11:116,796,370...116,956,334 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO RGD PMID:23697932 RGD:9479164 NCBI chr 1:109,819,748...109,912,763
Ensembl chr 1:109,853,758...109,908,113 		JBrowse link
G KMT2C lysine methyltransferase 2C ISO RGD PMID:23697932 RGD:9479164 NCBI chr21:120,299,295...120,587,843
Ensembl chr21:120,301,188...120,587,137 		JBrowse link
G MBD1 methyl-CpG binding domain protein 1 ISO RGD PMID:23324617 RGD:8695954 NCBI chr18:30,675,419...30,690,111
Ensembl chr18:30,675,653...30,685,946 		JBrowse link
G MBD2 methyl-CpG binding domain protein 2 ISO RGD PMID:23324617 RGD:8695954 NCBI chr18:26,714,610...26,785,028 JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase ISO RGD PMID:23324617 RGD:8695954 NCBI chr22:51,616,840...51,626,232
Ensembl chr22:51,616,803...51,626,224 		JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO RGD PMID:23324617 RGD:8695954 NCBI chr  X:128,445,028...128,519,892
Ensembl chr  X:128,453,577...128,455,785 		JBrowse link
G NANOG Nanog homeobox ISO RGD PMID:24825349 RGD:8695944 NCBI chr11:7,813,309...7,820,009 JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase ISO RGD PMID:24825349 RGD:8695944 NCBI chr  X:61,351,047...61,393,541
Ensembl chr  X:61,351,054...61,394,305 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:24825349 RGD:8695944 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G PRDM14 PR/SET domain 14 ISO RGD PMID:24825349 RGD:8695944 NCBI chr 8:65,800,454...65,820,190
Ensembl chr 8:65,800,923...65,819,456 		JBrowse link
G SIN3A SIN3 transcription regulator family member A ISO RGD PMID:24825349 RGD:8695944 NCBI chr26:7,971,208...8,060,888
Ensembl chr26:7,975,484...8,058,278 		JBrowse link
G SPI1 Spi-1 proto-oncogene ISO RGD PMID:24825349 RGD:8695944 NCBI chr 1:17,935,037...17,961,638
Ensembl chr 1:17,935,922...17,961,717 		JBrowse link
G TET1 tet methylcytosine dioxygenase 1 ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr 9:62,709,800...62,843,322
Ensembl chr 9:62,712,484...62,837,138 		JBrowse link
G TET2 tet methylcytosine dioxygenase 2 ISO RGD PMID:22770212 PMID:24825349 RGD:8695943 RGD:8695944 NCBI chr 7:53,193,824...53,326,813
Ensembl chr 7:53,193,941...53,326,942 		JBrowse link
G TET3 tet methylcytosine dioxygenase 3 ISO RGD PMID:22770212 PMID:23697932 PMID:24825349 RGD:8695943 RGD:8695944 RGD:9479164 NCBI chr14:33,170,046...33,293,128
Ensembl chr14:33,176,039...33,293,906 		JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 ISO RGD PMID:23324617 RGD:8695954 NCBI chr 6:4,592,362...4,642,179
Ensembl chr 6:4,592,919...4,642,445 		JBrowse link
G UHRF2 ubiquitin like with PHD and ring finger domains 2 ISO RGD PMID:23324617 RGD:8695954 NCBI chr12:73,010,697...73,106,163
Ensembl chr12:73,007,830...73,106,120 		JBrowse link
G ZBTB33 zinc finger and BTB domain containing 33 ISO RGD PMID:23324617 RGD:8695954
G ZBTB38 zinc finger and BTB domain containing 38 ISO RGD PMID:23324617 RGD:8695954 NCBI chr15:49,160,877...49,203,378
Ensembl chr15:49,160,896...49,164,486 		JBrowse link
G ZBTB4 zinc finger and BTB domain containing 4 ISO RGD PMID:23324617 RGD:8695954 NCBI chr16:6,836,070...6,855,523
Ensembl chr16:6,835,954...6,860,133 		JBrowse link
G ZFP57 ZFP57 zinc finger protein ISO RGD PMID:23324617 RGD:8695954 NCBI chr17:42,942,002...42,947,064 JBrowse link
folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr22:54,848,868...54,933,415
Ensembl chr22:54,848,901...54,934,629 		JBrowse link
G AMT aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chr22:10,813,601...10,820,628
Ensembl chr22:10,814,358...10,819,632 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 4:74,787,292...74,811,196
Ensembl chr 4:74,787,629...74,810,960 		JBrowse link
G DLD dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr21:76,795,573...76,825,504
Ensembl chr21:76,795,592...76,824,923 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 4:73,217,523...73,339,646
Ensembl chr 4:73,216,579...73,290,268 		JBrowse link
G FOLR1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:63,405,513...63,413,372
Ensembl chr 1:63,406,597...63,413,352 		JBrowse link
G FOLR2 folate receptor beta ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:63,436,430...63,441,924
Ensembl chr 1:63,436,684...63,441,743 		JBrowse link
G FPGS folylpolyglutamate synthase ISO RGD PMID:16859665 RGD:7242559 NCBI chr12:10,316,664...10,329,497
Ensembl chr12:10,317,137...10,335,271 		JBrowse link
G GCSH glycine cleavage system protein H ISO RGD PMID:20645850 RGD:7242560 NCBI chr 5:66,538,377...66,551,068
Ensembl chr 5:66,538,871...66,550,817 		JBrowse link
G GGH gamma-glutamyl hydrolase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 8:58,908,524...58,932,885
Ensembl chr 8:58,908,417...58,932,685 		JBrowse link
G GLDC glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chr12:72,876,992...72,990,671
Ensembl chr12:72,877,017...72,990,668 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO RGD PMID:22108709 RGD:7242557 NCBI chr13:78,306,770...78,539,884
Ensembl chr13:78,306,821...78,477,200 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chr14:33,063,485...33,080,703
Ensembl chr14:33,064,542...33,080,366 		JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 7:22,696,362...22,838,955
Ensembl chr 7:22,696,309...22,838,967 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 4:7,461,521...7,493,032
Ensembl chr 4:7,461,526...7,493,840 		JBrowse link
G SARDH sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr12:4,397,312...4,469,890
Ensembl chr12:4,397,539...4,469,562 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr16:17,371,704...17,408,499 JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chr11:53,141,435...53,146,625
Ensembl chr11:53,141,462...53,147,795 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chr 2:89,188,171...89,232,081
Ensembl chr 2:89,188,733...89,209,281 		JBrowse link
G SLC25A32 solute carrier family 25 member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chr 8:98,256,793...98,271,347
Ensembl chr 8:98,254,852...98,271,514 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chr16:22,164,661...22,173,376
Ensembl chr16:22,166,318...22,173,240 		JBrowse link
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:14729668 RGD:1547843 NCBI chr22:54,848,868...54,933,415
Ensembl chr22:54,848,901...54,934,629 		JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:9332377 PMID:22332074 RGD:70804 RGD:7242561 NCBI chr10:101,128,583...101,166,668 JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:11502523 PMID:22332074 RGD:1298877 RGD:7242561 NCBI chr 4:74,787,292...74,811,196
Ensembl chr 4:74,787,629...74,810,960 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chr 4:73,217,523...73,339,646
Ensembl chr 4:73,216,579...73,290,268 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 PMID:22332074 RGD:1547842 RGD:7242561 NCBI chr 2:58,641,566...58,682,014
Ensembl chr 2:58,643,877...58,683,023 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:8278367 RGD:1545057 NCBI chr17:29,196,142...29,199,728
Ensembl chr17:29,196,321...29,198,947 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:2186031 PMID:22332074 RGD:1299513 RGD:7242561 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:9454603 RGD:1540378 NCBI chr14:33,063,485...33,080,703
Ensembl chr14:33,064,542...33,080,366 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:11933257 PMID:22332074 RGD:1535021 RGD:7242561 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 PMID:20814827 RGD:1359026 RGD:7242426 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr 4:7,461,521...7,493,032
Ensembl chr 4:7,461,526...7,493,840 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chr16:17,371,704...17,408,499 JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chr11:53,141,435...53,146,625
Ensembl chr11:53,141,462...53,147,795 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:9894005 PMID:22332074 RGD:1545055 RGD:7242561 NCBI chr18:60,030,640...60,043,297
Ensembl chr18:60,030,658...60,041,856 		JBrowse link
folate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD
SMPDB		 PMID:14729668 RGD:1547843 SMP:00053 NCBI chr22:54,848,868...54,933,415
Ensembl chr22:54,848,901...54,934,629 		JBrowse link
G DHFR dihydrofolate reductase ISO SMPDB
RGD		 PMID:11502523 RGD:1298877 SMP:00053 NCBI chr 4:74,787,292...74,811,196
Ensembl chr 4:74,787,629...74,810,960 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chr 4:73,217,523...73,339,646
Ensembl chr 4:73,216,579...73,290,268 		JBrowse link
G FOLR2 folate receptor beta ISO RGD PMID:8445646 RGD:1540379 NCBI chr 1:63,436,430...63,441,924
Ensembl chr 1:63,436,684...63,441,743 		JBrowse link
G FPGS folylpolyglutamate synthase ISO SMPDB SMP:00053 NCBI chr12:10,316,664...10,329,497
Ensembl chr12:10,317,137...10,335,271 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 RGD:1547842 NCBI chr 2:58,641,566...58,682,014
Ensembl chr 2:58,643,877...58,683,023 		JBrowse link
G GGH gamma-glutamyl hydrolase ISO SMPDB SMP:00053 NCBI chr 8:58,908,524...58,932,885
Ensembl chr 8:58,908,417...58,932,685 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:15347642 RGD:1359070 NCBI chr17:29,196,142...29,199,728
Ensembl chr17:29,196,321...29,198,947 		JBrowse link
G LOC103220313 formimidoyltransferase-cyclodeaminase ISO SMPDB SMP:00053 NCBI chr 2:89,761,600...89,778,572
Ensembl chr 2:89,761,248...89,782,238 		JBrowse link
G MTFMT mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00053 NCBI chr26:18,556,747...18,583,528
Ensembl chr26:18,556,791...18,583,446 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO SMPDB
RGD		 PMID:2186031 RGD:1299513 SMP:00053 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO SMPDB SMP:00053 NCBI chr13:78,306,770...78,539,884
Ensembl chr13:78,306,821...78,477,200 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB
RGD		 PMID:9454603 RGD:1540378 SMP:00053 NCBI chr14:33,063,485...33,080,703
Ensembl chr14:33,064,542...33,080,366 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD
SMPDB		 PMID:11933257 RGD:1535021 SMP:00053 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 RGD:1359026 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 RGD:1359037 NCBI chr 4:7,461,521...7,493,032
Ensembl chr 4:7,461,526...7,493,840 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:15671219 RGD:1359815 NCBI chr16:17,371,704...17,408,499 JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:15671219 RGD:1359815 NCBI chr11:53,141,435...53,146,625
Ensembl chr11:53,141,462...53,147,795 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO RGD PMID:11600421 RGD:735239 NCBI chr 2:89,188,171...89,232,081
Ensembl chr 2:89,188,733...89,209,281 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO SMPDB SMP:00053 NCBI chr16:22,164,661...22,173,376
Ensembl chr16:22,166,318...22,173,240 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:9894005 RGD:1545055 NCBI chr18:60,030,640...60,043,297
Ensembl chr18:60,030,658...60,041,856 		JBrowse link
histone modification pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AEBP2 AE binding protein 2 ISO RGD PMID:24148750 RGD:9479059 NCBI chr11:19,288,551...19,401,925
Ensembl chr11:19,288,493...19,374,301 		JBrowse link
G APLF aprataxin and PNKP like factor ISO RGD PMID:23288364 RGD:9068945 NCBI chr14:38,539,398...38,636,666
Ensembl chr14:38,540,084...38,636,569 		JBrowse link
G ASF1A anti-silencing function 1A histone chaperone ISO RGD PMID:23288364 RGD:9068945 NCBI chr13:54,972,514...54,988,436
Ensembl chr13:54,969,299...54,988,558 		JBrowse link
G ASF1B anti-silencing function 1B histone chaperone ISO RGD PMID:23288364 RGD:9068945 NCBI chr 6:12,760,865...12,773,423 JBrowse link
G ASH1L ASH1 like histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr20:8,290,606...8,499,991
Ensembl chr20:8,322,504...8,500,129 		JBrowse link
G ASH2L ASH2 like, histone lysine methyltransferase complex subunit ISO RGD PMID:22663077 RGD:9479053 NCBI chr 8:36,125,359...36,163,142 JBrowse link
G BAP1 BRCA1 associated deubiquitinase 1 ISO RGD PMID:24647359 RGD:9479061 NCBI chr22:13,765,510...13,774,866
Ensembl chr22:13,764,686...13,774,740 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISO RGD PMID:23642229 RGD:9479074 NCBI chr16:70,226,824...70,237,000 JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 9:22,095,592...22,104,894 JBrowse link
G BPTF bromodomain PHD finger transcription factor ISO RGD PMID:23642229 PMID:24686119 RGD:9479074 RGD:9479075 NCBI chr16:53,478,706...53,634,617
Ensembl chr16:53,478,464...53,634,183 		JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 ISO RGD PMID:24647359 RGD:9479061 NCBI chr  X:129,358,759...129,406,293
Ensembl chr  X:129,358,862...129,403,352 		JBrowse link
G BRD1 bromodomain containing 1 ISO RGD PMID:24686119 RGD:9479075 NCBI chr19:32,261,796...32,323,528
Ensembl chr19:32,261,833...32,320,706 		JBrowse link
G BRD2 bromodomain containing 2 ISO RGD PMID:24686119 RGD:9479075 NCBI chr17:39,113,519...39,126,267 JBrowse link
G BRD3 bromodomain containing 3 ISO RGD PMID:24686119 RGD:9479075 NCBI chr12:4,075,123...4,112,727
Ensembl chr12:4,089,621...4,109,441 		JBrowse link
G BRD4 bromodomain containing 4 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 6:13,836,332...13,883,459
Ensembl chr 6:13,836,324...13,873,877 		JBrowse link
G BRD7 bromodomain containing 7 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 5:36,114,951...36,168,786
Ensembl chr 5:36,112,289...36,168,728 		JBrowse link
G BRDT bromodomain testis associated ISO RGD PMID:24686119 RGD:9479075 NCBI chr20:41,229,493...41,293,899
Ensembl chr20:41,229,643...41,280,341 		JBrowse link
G BRF1 BRF1 RNA polymerase III transcription initiation factor subunit ISO RGD PMID:23642229 RGD:9479074 NCBI chr24:83,117,823...83,192,435
Ensembl chr24:83,117,685...83,192,431 		JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 6:9,866,715...9,915,655
Ensembl chr 6:9,866,534...9,914,682 		JBrowse link
G CBX2 chromobox 2 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr16:71,741,476...71,749,234
Ensembl chr16:71,741,500...71,751,817 		JBrowse link
G CBX4 chromobox 4 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr16:71,795,919...71,802,184
Ensembl chr16:71,795,862...71,802,051 		JBrowse link
G CBX5 chromobox 5 ISO RGD PMID:23642229 RGD:9479074 NCBI chr11:50,350,440...50,396,595
Ensembl chr11:50,353,638...50,396,608 		JBrowse link
G CBX6 chromobox 6 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr19:21,525,609...21,536,406
Ensembl chr19:21,525,596...21,536,352 		JBrowse link
G CBX7 chromobox 7 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr19:21,776,618...21,798,525
Ensembl chr19:21,775,931...21,798,309 		JBrowse link
G CBX8 chromobox 8 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr16:71,755,598...71,760,611
Ensembl chr16:71,755,627...71,760,632 		JBrowse link
G CHAF1A chromatin assembly factor 1 subunit A ISO RGD PMID:23288364 RGD:9068945 NCBI chr 6:4,134,405...4,174,281
Ensembl chr 6:4,137,738...4,174,988 		JBrowse link
G CHAF1B chromatin assembly factor 1 subunit B ISO RGD PMID:23288364 RGD:9068945 NCBI chr 2:80,379,637...80,409,626
Ensembl chr 2:80,380,425...80,409,687 		JBrowse link
G CHD1 chromodomain helicase DNA binding protein 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr23:2,433,694...2,507,334
Ensembl chr23:2,432,461...2,507,704 		JBrowse link
G CREBBP CREB binding protein ISO RGD PMID:21151613 PMID:24686119 RGD:9104959 RGD:9479075 NCBI chr 5:3,415,548...3,570,030
Ensembl chr 5:3,415,412...3,540,943 		JBrowse link
G CXXC1 CXXC finger protein 1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr18:30,668,879...30,674,841
Ensembl chr18:30,668,821...30,675,301 		JBrowse link
G DAXX death domain associated protein ISO RGD PMID:23288364 RGD:9068945 NCBI chr17:38,754,227...38,758,714
Ensembl chr17:38,754,280...38,759,071 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr 6:1,962,077...2,030,732
Ensembl chr 6:1,962,279...2,026,455 		JBrowse link
G DPF3 double PHD fingers 3 ISO RGD PMID:23642229 RGD:9479074 NCBI chr24:49,857,853...50,144,326
Ensembl chr24:49,857,847...49,996,731 		JBrowse link
G DPY30 dpy-30 histone methyltransferase complex regulatory subunit ISO RGD PMID:22663077 RGD:9479053 NCBI chr14:75,455,246...75,471,807 JBrowse link
G EHMT1 euchromatic histone lysine methyltransferase 1 ISO RGD PMID:23200123 RGD:7242632 NCBI chr12:380,041...545,333
Ensembl chr12:379,943...497,033 		JBrowse link
G EHMT2 euchromatic histone lysine methyltransferase 2 ISO RGD PMID:23200123 PMID:23642229 RGD:7242632 RGD:9479074 NCBI chr17:40,123,935...40,141,942
Ensembl chr17:40,124,640...40,141,616 		JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:21151613 RGD:9104959 NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:23200123 RGD:7242632 NCBI chr21:117,380,518...117,515,224
Ensembl chr21:117,380,361...117,421,573 		JBrowse link
G H2AFX histone H2AX ISO RGD PMID:24614311 RGD:9075965 NCBI chr 1:110,466,692...110,468,776
Ensembl chr 1:110,467,775...110,468,206 		JBrowse link
G H2AFY core histone macro-H2A.1 ISO RGD PMID:24696452 RGD:9074213 NCBI chr23:38,113,212...38,178,227
Ensembl chr23:38,113,195...38,168,382 		JBrowse link
G H2AFY2 H2A histone family member Y2 ISO RGD PMID:24696452 RGD:9074213 NCBI chr 9:61,194,887...61,254,361
Ensembl chr 9:61,195,431...61,231,228 		JBrowse link
G HAT1 histone acetyltransferase 1 ISO RGD PMID:21151613 RGD:9104959 NCBI chr10:57,412,916...57,482,682
Ensembl chr10:57,412,910...57,482,351 		JBrowse link
G HCFC1 host cell factor C1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr  X:128,371,518...128,395,920
Ensembl chr  X:128,371,517...128,394,861 		JBrowse link
G HDAC1 histone deacetylase 1 ISO RGD PMID:21151613 RGD:9104959 NCBI chr20:100,529,782...100,575,953
Ensembl chr20:100,530,369...100,558,556 		JBrowse link
G HDAC10 histone deacetylase 10 ISO RGD PMID:21151613 RGD:9104959 NCBI chr19:32,735,091...32,741,200
Ensembl chr19:32,735,406...32,740,817 		JBrowse link
G HDAC11 histone deacetylase 11 ISO RGD PMID:21151613 RGD:9104959 NCBI chr22:49,470,443...49,497,692
Ensembl chr22:49,471,368...49,498,178 		JBrowse link
G HDAC2 histone deacetylase 2 ISO RGD PMID:21151613 RGD:9104959 NCBI chr13:59,873,248...59,904,542
Ensembl chr13:59,873,767...59,905,742 		JBrowse link
G HDAC3 histone deacetylase 3 ISO RGD PMID:21151613 RGD:9104959 NCBI chr23:44,246,296...44,263,127 JBrowse link
G HDAC4 histone deacetylase 4 ISO RGD PMID:21151613 RGD:9104959 NCBI chr10:125,098,375...125,450,524
Ensembl chr10:125,098,366...125,403,227 		JBrowse link
G HDAC5 histone deacetylase 5 ISO RGD PMID:21151613 RGD:9104959 NCBI chr16:62,267,837...62,314,914
Ensembl chr16:62,274,041...62,315,094 		JBrowse link
G HDAC6 histone deacetylase 6 ISO RGD PMID:21151613 RGD:9104959 NCBI chr  X:45,927,625...45,951,636
Ensembl chr  X:45,928,092...45,952,929 		JBrowse link
G HDAC7 histone deacetylase 7 ISO RGD PMID:21151613 RGD:9104959 NCBI chr11:44,002,616...44,040,766
Ensembl chr11:44,003,736...44,039,902 		JBrowse link
G HDAC8 histone deacetylase 8 ISO RGD PMID:21151613 RGD:9104959 NCBI chr  X:62,154,374...62,393,149
Ensembl chr  X:62,154,365...62,393,196 		JBrowse link
G HDAC9 histone deacetylase 9 ISO RGD PMID:21151613 RGD:9104959 NCBI chr21:39,159,270...39,859,403 JBrowse link
G HIRA histone cell cycle regulator ISO RGD PMID:23288364 RGD:9068945 NCBI chr19:6,324,050...6,424,999
Ensembl chr19:6,324,253...6,425,641 		JBrowse link
G HJURP Holliday junction recognition protein ISO RGD PMID:23288364 RGD:9068945 NCBI chr10:119,857,118...119,885,945
Ensembl chr10:119,868,303...119,885,783 		JBrowse link
G ING2 inhibitor of growth family member 2 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 7:129,486,978...129,493,740
Ensembl chr 7:129,487,339...129,493,596 		JBrowse link
G JMJD1C jumonji domain containing 1C ISO RGD PMID:23200123 RGD:7242632 NCBI chr 9:67,913,062...68,135,555 JBrowse link
G KAT2A lysine acetyltransferase 2A ISO RGD PMID:21151613 PMID:23642229 RGD:9104959 RGD:9479074 NCBI chr16:64,146,146...64,154,726
Ensembl chr16:64,146,207...64,154,252 		JBrowse link
G KAT2B lysine acetyltransferase 2B ISO RGD PMID:21151613 RGD:9104959 NCBI chr15:64,769,590...64,885,536
Ensembl chr15:64,770,185...64,886,219 		JBrowse link
G KAT5 lysine acetyltransferase 5 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 1:8,528,097...8,544,512
Ensembl chr 1:8,526,788...8,544,972 		JBrowse link
G KAT6A lysine acetyltransferase 6A ISO RGD PMID:21151613 RGD:9104959 NCBI chr 8:39,912,120...40,035,776
Ensembl chr 8:39,911,776...39,962,735 		JBrowse link
G KAT6B lysine acetyltransferase 6B ISO RGD PMID:21151613 RGD:9104959 NCBI chr 9:56,340,579...56,525,809
Ensembl chr 9:56,340,026...56,536,512 		JBrowse link
G KAT7 lysine acetyltransferase 7 ISO RGD PMID:21151613 RGD:9104959 NCBI chr16:43,508,888...43,548,411
Ensembl chr16:43,510,483...43,548,517 		JBrowse link
G KAT8 lysine acetyltransferase 8 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 5:27,806,082...27,820,832
Ensembl chr 5:27,805,844...27,820,748 		JBrowse link
G KDM1A lysine demethylase 1A ISO RGD PMID:23200123 RGD:7242632 NCBI chr20:109,592,761...109,657,885
Ensembl chr20:109,593,074...109,657,839 		JBrowse link
G KDM1B lysine demethylase 1B ISO RGD PMID:23200123 RGD:7242632 NCBI chr17:53,919,859...53,987,326
Ensembl chr17:53,921,702...53,987,124 		JBrowse link
G KDM2A lysine demethylase 2A ISO RGD PMID:23200123 RGD:7242632 NCBI chr 1:7,004,109...7,152,072
Ensembl chr 1:7,003,784...7,082,720 		JBrowse link
G KDM2B lysine demethylase 2B ISO RGD PMID:23200123 RGD:7242632 NCBI chr11:116,805,541...116,957,236
Ensembl chr11:116,796,370...116,956,334 		JBrowse link
G KDM3A lysine demethylase 3A ISO RGD PMID:23200123 RGD:7242632 NCBI chr14:20,668,215...20,721,854
Ensembl chr14:20,668,821...20,720,759 		JBrowse link
G KDM3B lysine demethylase 3B ISO RGD PMID:23200123 RGD:7242632 NCBI chr23:41,027,490...41,111,560
Ensembl chr23:41,062,020...41,112,469 		JBrowse link
G KDM4A lysine demethylase 4A ISO RGD PMID:23200123 PMID:23642229 PMID:24035451 RGD:7242632 RGD:9479074 RGD:9479148 NCBI chr20:89,108,090...89,164,657
Ensembl chr20:89,073,876...89,164,663 		JBrowse link
G KDM4B lysine demethylase 4B ISO RGD PMID:23200123 RGD:7242632 NCBI chr 6:4,649,140...4,831,634
Ensembl chr 6:4,649,221...4,831,636 		JBrowse link
G KDM4C lysine demethylase 4C ISO RGD PMID:23200123 RGD:7242632 NCBI chr12:72,346,194...72,763,040
Ensembl chr12:72,347,071...72,761,666 		JBrowse link
G KDM5A lysine demethylase 5A ISO RGD PMID:23200123 RGD:7242632 NCBI chr11:285,206...381,481
Ensembl chr11:286,728...381,430 		JBrowse link
G KDM5B lysine demethylase 5B ISO RGD PMID:23200123 RGD:7242632 NCBI chr25:26,599,740...26,685,256
Ensembl chr25:26,600,736...26,683,632 		JBrowse link
G KDM5C lysine demethylase 5C ISO RGD PMID:23200123 RGD:7242632 NCBI chr  X:49,306,472...49,356,151
Ensembl chr  X:49,321,173...49,356,100 		JBrowse link
G KDM6A lysine demethylase 6A ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr  X:42,053,272...42,291,013
Ensembl chr  X:42,053,336...42,290,526 		JBrowse link
G KDM6B lysine demethylase 6B ISO RGD PMID:23200123 RGD:7242632 NCBI chr16:7,221,769...7,241,230
Ensembl chr16:7,232,426...7,241,040 		JBrowse link
G KDM7A lysine demethylase 7A ISO RGD PMID:23200123 RGD:7242632 NCBI chr21:108,857,596...108,949,793
Ensembl chr21:108,854,477...108,949,735 		JBrowse link
G KDM8 lysine demethylase 8 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 5:24,907,345...24,927,028
Ensembl chr 5:24,907,657...24,928,995 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr 1:109,819,748...109,912,763
Ensembl chr 1:109,853,758...109,908,113 		JBrowse link
G KMT2B lysine methyltransferase 2B ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr 6:30,626,723...30,648,204
Ensembl chr 6:30,626,848...30,647,883 		JBrowse link
G KMT2C lysine methyltransferase 2C ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr21:120,299,295...120,587,843
Ensembl chr21:120,301,188...120,587,137 		JBrowse link
G KMT2D lysine methyltransferase 2D ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr11:45,260,873...45,303,898
Ensembl chr11:45,263,408...45,302,423 		JBrowse link
G KMT2E lysine methyltransferase 2E (inactive) ISO RGD PMID:23200123 RGD:7242632 NCBI chr21:73,930,957...74,030,434
Ensembl chr21:73,930,932...74,029,673 		JBrowse link
G KMT5A lysine methyltransferase 5A ISO RGD PMID:23200123 RGD:7242632 NCBI chr11:118,712,964...118,743,322
Ensembl chr11:118,723,029...118,743,325 		JBrowse link
G KMT5B lysine methyltransferase 5B ISO RGD PMID:23200123 RGD:7242632 NCBI chr 1:6,308,565...6,367,272
Ensembl chr 1:6,308,742...6,367,393 		JBrowse link
G KMT5C lysine methyltransferase 5C ISO RGD PMID:23200123 RGD:7242632 NCBI chr 6:47,942,100...47,950,364
Ensembl chr 6:47,944,197...47,949,693 		JBrowse link
G L3MBTL1 L3MBTL histone methyl-lysine binding protein 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 2:20,253,598...20,299,022 JBrowse link
G LBR lamin B receptor ISO RGD PMID:24035451 RGD:9479148 NCBI chr25:4,326,872...4,353,208
Ensembl chr25:4,330,849...4,351,401 		JBrowse link
G LOC103230910 histone-lysine N-methyltransferase SMYD3 ISO RGD PMID:23200123 RGD:7242632 NCBI chr25:82,794,748...83,531,942 JBrowse link
G LOC103231004 histone H3.3A ISO RGD PMID:24614311 RGD:9075965 NCBI chr25:3,696,153...3,704,886 JBrowse link
G LOC103236032 histone H2A.Z ISO RGD PMID:24696452 RGD:9074213 NCBI chr 7:48,079,894...48,082,147 JBrowse link
G LOC103243033 histone H3.3A ISO RGD PMID:24614311 RGD:9075965 NCBI chr16:45,903,252...45,905,605
Ensembl chr16:45,902,980...45,904,929 		JBrowse link
G LOC103248265 lysine-specific demethylase 4D ISO RGD PMID:23200123 RGD:7242632 NCBI chr 1:86,190,515...86,215,061
Ensembl chr 1:86,212,761...86,214,490 		JBrowse link
G MCPH1 microcephalin 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 8:6,190,272...6,425,683
Ensembl chr 8:6,190,047...6,425,131 		JBrowse link
G MDC1 mediator of DNA damage checkpoint 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr17:41,735,584...41,754,618
Ensembl chr17:41,739,419...41,755,141 		JBrowse link
G MEN1 menin 1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104 		JBrowse link
G MYSM1 Myb like, SWIRM and MPN domains 1 ISO RGD PMID:24647359 RGD:9479061 NCBI chr20:74,284,627...74,323,651
Ensembl chr20:74,284,665...74,323,088 		JBrowse link
G NAP1L1 nucleosome assembly protein 1 like 1 ISO RGD PMID:23288364 RGD:9068945 NCBI chr11:71,639,965...71,679,131
Ensembl chr11:71,522,837...71,678,825 		JBrowse link
G NASP nuclear autoantigenic sperm protein ISO RGD PMID:23288364 RGD:9068945 NCBI chr20:87,180,440...87,215,418
Ensembl chr20:87,180,453...87,215,939 		JBrowse link
G NCOA6 nuclear receptor coactivator 6 ISO RGD PMID:22663077 RGD:9479053 NCBI chr 2:39,013,364...39,129,723
Ensembl chr 2:39,013,232...39,129,658 		JBrowse link
G NSD1 nuclear receptor binding SET domain protein 1 ISO RGD PMID:23200123 RGD:7242632 NCBI chr23:79,140,148...79,309,579
Ensembl chr23:79,141,114...79,304,820 		JBrowse link
G NSD3 nuclear receptor binding SET domain protein 3 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 8:36,288,997...36,398,334
Ensembl chr 8:36,291,104...36,398,246 		JBrowse link
G ORC1 origin recognition complex subunit 1 ISO RGD PMID:23642229 RGD:9479074 NCBI chr20:80,540,331...80,571,989
Ensembl chr20:80,542,532...80,572,237 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr 5:26,833,333...26,837,655
Ensembl chr 5:26,833,675...26,837,640 		JBrowse link
G PAXIP1 PAX interacting protein 1 ISO RGD PMID:22663077 RGD:9479053 NCBI chr21:123,095,968...123,156,157
Ensembl chr21:123,095,966...123,155,800 		JBrowse link
G PBRM1 polybromo 1 ISO RGD PMID:24686119 RGD:9479075 NCBI chr22:13,914,023...14,059,221
Ensembl chr22:13,913,285...14,055,254 		JBrowse link
G PCGF1 polycomb group ring finger 1 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr14:32,769,805...32,772,806
Ensembl chr14:32,770,492...32,772,804 		JBrowse link
G PCGF2 polycomb group ring finger 2 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr16:67,447,181...67,461,829
Ensembl chr16:67,455,292...67,460,509 		JBrowse link
G PCGF3 polycomb group ring finger 3 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr27:48,015,976...48,077,688
Ensembl chr27:48,020,010...48,053,520 		JBrowse link
G PCGF5 polycomb group ring finger 5 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 9:84,494,147...84,613,269
Ensembl chr 9:84,494,202...84,607,330 		JBrowse link
G PCGF6 polycomb group ring finger 6 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr 9:96,349,418...96,396,083
Ensembl chr 9:96,349,423...96,395,650 		JBrowse link
G PHC1 polyhomeotic homolog 1 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr11:8,733,769...8,759,430
Ensembl chr11:8,733,988...8,758,600 		JBrowse link
G PHC2 polyhomeotic homolog 2 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr20:99,447,099...99,558,783
Ensembl chr20:99,507,489...99,557,540 		JBrowse link
G PHC3 polyhomeotic homolog 3 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr15:19,214,818...19,308,248
Ensembl chr15:19,217,677...19,293,583 		JBrowse link
G PHF1 PHD finger protein 1 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr17:38,650,013...38,655,458
Ensembl chr17:38,648,140...38,655,420 		JBrowse link
G PHF19 PHD finger protein 19 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr12:18,698,705...18,722,702
Ensembl chr12:18,702,523...18,720,446 		JBrowse link
G PHF2 PHD finger protein 2 ISO RGD PMID:23200123 RGD:7242632 NCBI chr12:103,959,502...104,055,711
Ensembl chr12:104,007,498...104,055,711 		JBrowse link
G PHF8 PHD finger protein 8 ISO RGD PMID:23200123 RGD:7242632 NCBI chr  X:50,058,687...50,172,827
Ensembl chr  X:50,058,273...50,172,086 		JBrowse link
G PRDM16 PR/SET domain 16 ISO RGD PMID:23200123 RGD:7242632 NCBI chr20:128,249,894...128,613,842 JBrowse link
G PRDM2 PR/SET domain 2 ISO RGD PMID:23200123 RGD:7242632 NCBI chr20:118,437,171...118,565,554
Ensembl chr20:118,436,717...118,550,461 		JBrowse link
G PRDM6 PR/SET domain 6 ISO RGD PMID:23200123 RGD:7242632 NCBI chr23:26,148,811...26,269,255
Ensembl chr23:26,149,678...26,247,674 		JBrowse link
G PRDM8 PR/SET domain 8 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 7:28,610,166...28,631,712
Ensembl chr 7:28,626,265...28,629,707 		JBrowse link
G PRDM9 PR/SET domain 9 ISO RGD PMID:23200123 RGD:7242632 NCBI chr 4:22,902,119...22,922,193 JBrowse link
G PRMT1 protein arginine methyltransferase 1 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 6:42,854,873...42,863,113
Ensembl chr 6:42,854,918...42,863,014 		JBrowse link
G PRMT2 protein arginine methyltransferase 2 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 2:90,225,051...90,256,541
Ensembl chr 2:90,225,346...90,256,558 		JBrowse link
G PRMT5 protein arginine methyltransferase 5 ISO RGD PMID:24583552 RGD:9479047 NCBI chr29:23,288,458...23,297,746
Ensembl chr29:23,288,835...23,297,518 		JBrowse link
G PRMT6 protein arginine methyltransferase 6 ISO RGD PMID:24583552 RGD:9479047 NCBI chr20:26,547,305...26,551,327
Ensembl chr20:26,550,130...26,551,257 		JBrowse link
G PRMT7 protein arginine methyltransferase 7 ISO RGD PMID:24583552 RGD:9479047 NCBI chr 5:59,058,827...59,106,177
Ensembl chr 5:59,058,846...59,106,106 		JBrowse link
G RAG2 recombination activating 2 ISO RGD PMID:23642229 RGD:9479074 NCBI chr 1:28,645,175...28,653,823
Ensembl chr 1:28,649,930...28,651,513 		JBrowse link
G RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit ISO RGD PMID:22663077 RGD:9479053 NCBI chr25:24,217,090...24,253,532
Ensembl chr25:24,217,125...24,256,420 		JBrowse link
G RING1 ring finger protein 1 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr17:38,862,411...38,866,631
Ensembl chr17:38,860,729...38,866,371 		JBrowse link
G RNF2 ring finger protein 2 ISO RGD PMID:23473600 PMID:25065329 RGD:9479058 RGD:9479060 NCBI chr25:44,289,662...44,345,168
Ensembl chr25:44,291,576...44,345,236 		JBrowse link
G SETD1A SET domain containing 1A, histone lysine methyltransferase ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr 5:27,645,908...27,675,500
Ensembl chr 5:27,648,378...27,674,860 		JBrowse link
G SETD1B SET domain containing 1B, histone lysine methyltransferase ISO RGD PMID:22663077 PMID:23200123 RGD:7242632 RGD:9479053 NCBI chr11:117,173,611...117,201,689
Ensembl chr11:117,173,826...117,192,773 		JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr22:8,421,178...8,567,221
Ensembl chr22:8,420,960...8,567,201 		JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr 7:86,476,101...86,528,146
Ensembl chr 7:86,481,726...86,527,779 		JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 ISO RGD PMID:23200123 RGD:7242632
G SGF29 SAGA complex associated factor 29 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr 5:26,399,760...26,439,616
Ensembl chr 5:26,399,677...26,439,530 		JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 9:63,463,059...63,497,893
Ensembl chr 9:63,462,389...63,497,867 		JBrowse link
G SIRT2 sirtuin 2 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 6:33,493,106...33,518,793
Ensembl chr 6:33,493,079...33,518,647 		JBrowse link
G SIRT3 sirtuin 3 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 1:25,740...49,471
Ensembl chr 1:26,927...48,944 		JBrowse link
G SIRT4 sirtuin 4 ISO RGD PMID:21151613 RGD:9104959 NCBI chr11:115,640,976...115,659,074
Ensembl chr11:115,640,555...115,658,687 		JBrowse link
G SIRT5 sirtuin 5 ISO RGD PMID:21151613 RGD:9104959 NCBI chr17:58,535,645...58,573,769
Ensembl chr17:58,532,650...58,563,818 		JBrowse link
G SIRT6 sirtuin 6 ISO RGD PMID:21151613 RGD:9104959 NCBI chr 6:3,924,230...3,932,583
Ensembl chr 6:3,924,230...3,932,590 		JBrowse link
G SIRT7 sirtuin 7 ISO RGD PMID:21151613 RGD:9104959 NCBI chr16:73,785,223...73,792,773
Ensembl chr16:73,785,695...73,791,947 		JBrowse link
G SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 ISO RGD PMID:24686119 RGD:9479075 NCBI chr12:77,364,468...77,546,356
Ensembl chr12:77,375,500...77,546,314 		JBrowse link
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ISO RGD PMID:24686119 RGD:9479075 NCBI chr 6:9,943,162...10,044,476 JBrowse link
G SMYD1 SET and MYND domain containing 1 ISO RGD PMID:23200123 RGD:7242632 NCBI chr14:18,676,396...18,721,532
Ensembl chr14:18,676,394...18,720,903 		JBrowse link
G SMYD2 SET and MYND domain containing 2 ISO RGD PMID:23200123 RGD:7242632 NCBI chr25:15,236,773...15,293,154
Ensembl chr25:15,235,653...15,293,153 		JBrowse link
G SPIN1 spindlin 1 ISO RGD PMID:24035451 RGD:9479148 NCBI chr12:98,880,918...98,964,988
Ensembl chr12:98,913,798...98,960,934 		JBrowse link
G SSRP1 structure specific recognition protein 1 ISO RGD PMID:23288364 RGD:9068945 NCBI chr 1:15,907,874...15,918,376
Ensembl chr 1:15,908,495...15,918,596 		JBrowse link
G SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit ISO RGD PMID:23288364 RGD:9068945 NCBI chr29:21,822,520...21,855,552
Ensembl chr29:21,822,393...21,855,923 		JBrowse link
G SUV39H1 SUV39H1 histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr  X:45,820,114...45,834,727
Ensembl chr  X:45,822,453...45,834,917 		JBrowse link
G SUV39H2 SUV39H2 histone lysine methyltransferase ISO RGD PMID:23200123 RGD:7242632 NCBI chr 9:14,900,503...14,924,017
Ensembl chr 9:14,900,945...14,923,447 		JBrowse link
G TAF1 TATA-box binding protein associated factor 1 ISO RGD PMID:23642229 PMID:24686119 RGD:9479074 RGD:9479075 NCBI chr  X:61,167,743...61,269,000
Ensembl chr  X:61,167,589...61,268,839 		JBrowse link
G TDRD3 tudor domain containing 3 ISO RGD PMID:23211769 PMID:24035451 RGD:9479148 RGD:9479163 NCBI chr 3:38,174,141...38,361,626
Ensembl chr 3:38,174,990...38,361,622 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr26:39,489,925...39,595,096
Ensembl chr26:39,508,600...39,594,927 		JBrowse link
G TRIM24 tripartite motif containing 24 ISO RGD PMID:23642229 RGD:9479074 NCBI chr21:107,166,180...107,291,897
Ensembl chr21:107,166,395...107,295,736 		JBrowse link
G TRIM33 tripartite motif containing 33 ISO RGD PMID:23642229 PMID:24686119 RGD:9479074 RGD:9479075 NCBI chr20:19,154,902...19,274,790
Ensembl chr20:19,154,933...19,274,779 		JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 ISO RGD PMID:23642229 PMID:24035451 RGD:9479074 RGD:9479148 NCBI chr 6:4,592,362...4,642,179
Ensembl chr 6:4,592,919...4,642,445 		JBrowse link
G USP12 ubiquitin specific peptidase 12 ISO RGD PMID:24647359 RGD:9479061 NCBI chr 3:6,282,629...6,382,797 JBrowse link
G USP16 ubiquitin specific peptidase 16 ISO RGD PMID:24647359 RGD:9479061 NCBI chr 2:63,170,677...63,201,257
Ensembl chr 2:63,170,979...63,201,445 		JBrowse link
G USP21 ubiquitin specific peptidase 21 ISO RGD PMID:24647359 RGD:9479061 NCBI chr20:2,820,012...2,826,817
Ensembl chr20:2,820,333...2,825,131 		JBrowse link
G USP22 ubiquitin specific peptidase 22 ISO RGD PMID:24647359 RGD:9479061 NCBI chr16:19,110,710...19,151,565
Ensembl chr16:19,107,508...19,151,603 		JBrowse link
G USP3 ubiquitin specific peptidase 3 ISO RGD PMID:24647359 RGD:9479061 NCBI chr26:19,947,806...20,030,515
Ensembl chr26:19,948,453...19,992,638 		JBrowse link
G USP44 ubiquitin specific peptidase 44 ISO RGD PMID:24647359 RGD:9479061 NCBI chr11:90,915,107...90,950,142
Ensembl chr11:90,916,677...90,947,456 		JBrowse link
G WDR5 WD repeat domain 5 ISO RGD PMID:22663077 PMID:23642229 RGD:9479053 RGD:9479074 NCBI chr12:3,982,998...4,007,605
Ensembl chr12:3,983,013...4,007,119 		JBrowse link
G WDR82 WD repeat domain 82 ISO RGD PMID:22663077 RGD:9479053 NCBI chr22:13,617,169...13,638,896 JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO RGD PMID:23642229 RGD:9479074 NCBI chr 8:95,786,197...95,821,270
Ensembl chr 8:95,788,305...95,819,197 		JBrowse link
homocysteine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase ISO RGD PMID:11741948 PMID:20814827 RGD:7242426 RGD:730275 NCBI chr 2:38,579,254...38,601,218
Ensembl chr 2:38,579,024...38,601,208 		JBrowse link
G AS3MT arsenite methyltransferase ISO RGD PMID:11790780 RGD:625365 NCBI chr 9:95,911,465...95,939,554
Ensembl chr 9:95,912,086...95,939,375 		JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 ISO RGD PMID:15866169 RGD:1359044 NCBI chr 6:9,866,715...9,915,655
Ensembl chr 6:9,866,534...9,914,682 		JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:12584150 RGD:1359089 NCBI chr19:5,775,829...5,803,260
Ensembl chr19:5,773,225...5,785,422 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO RGD PMID:12473678 RGD:1359078 NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607 		JBrowse link
G GAMT guanidinoacetate N-methyltransferase ISO RGD PMID:15533043 RGD:1359081 NCBI chr 6:1,165,016...1,178,458
Ensembl chr 6:1,164,259...1,178,354 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:15347642 RGD:1359070 NCBI chr17:29,196,142...29,199,728
Ensembl chr17:29,196,321...29,198,947 		JBrowse link
G HNMT histamine N-methyltransferase ISO RGD PMID:11566133 RGD:1359041 NCBI chr10:22,188,151...22,238,665
Ensembl chr10:22,188,110...22,238,671 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G NNMT nicotinamide N-methyltransferase ISO RGD PMID:15922112 RGD:1359084 NCBI chr 1:105,650,178...105,708,441
Ensembl chr 1:105,690,085...105,713,010 		JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO RGD PMID:8263531 RGD:729481 NCBI chr13:21,808,583...21,867,309
Ensembl chr13:21,807,710...21,866,768 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO RGD PMID:8344945 RGD:729486 NCBI chr16:16,540,096...16,626,251
Ensembl chr16:16,539,985...16,611,279 		JBrowse link
G PNMT phenylethanolamine N-methyltransferase ISO RGD PMID:12438084 RGD:1359087 NCBI chr16:66,496,290...66,498,840
Ensembl chr16:66,496,027...66,499,111 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 ISO RGD PMID:15866169 RGD:1359044 NCBI chr 6:42,854,873...42,863,113
Ensembl chr 6:42,854,918...42,863,014 		JBrowse link
G PRMT5 protein arginine methyltransferase 5 ISO RGD PMID:15866169 RGD:1359044 NCBI chr29:23,288,458...23,297,746
Ensembl chr29:23,288,835...23,297,518 		JBrowse link
G PRMT6 protein arginine methyltransferase 6 ISO RGD PMID:15866169 RGD:1359044 NCBI chr20:26,547,305...26,551,327
Ensembl chr20:26,550,130...26,551,257 		JBrowse link
G RNMT RNA guanine-7 methyltransferase ISO RGD PMID:11472630 RGD:1359071 NCBI chr18:72,203,405...72,242,527
Ensembl chr18:72,208,648...72,243,940 		JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 ISO RGD PMID:11959841 RGD:1359072
methionine cycle/metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase ISO SMPDB
RGD		 PMID:2292587 PMID:11741948 PMID:23073625 RGD:7242425 RGD:7242932 RGD:730275 SMP:00033 NCBI chr 2:38,579,254...38,601,218
Ensembl chr 2:38,579,024...38,601,208 		JBrowse link
G AMD1 adenosylmethionine decarboxylase 1 ISO SMPDB
RGD		 PMID:2292587 PMID:23073625 RGD:7242425 RGD:7242932 SMP:00033 NCBI chr13:62,977,659...62,999,150 JBrowse link
G AS3MT arsenite methyltransferase ISO RGD PMID:11790780 RGD:625365 NCBI chr 9:95,911,465...95,939,554
Ensembl chr 9:95,912,086...95,939,375 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase ISO SMPDB
RGD		 PMID:15845641 PMID:23073625 RGD:1359026 RGD:7242425 SMP:00033 NCBI chr 4:73,331,551...73,352,259
Ensembl chr 4:73,332,259...73,352,434 		JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044 RGD:7242552 NCBI chr 6:9,866,715...9,915,655
Ensembl chr 6:9,866,534...9,914,682 		JBrowse link
G CHDH choline dehydrogenase ISO SMPDB SMP:00033 NCBI chr22:15,197,568...15,228,613
Ensembl chr22:15,197,170...15,205,352 		JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:12584150 RGD:1359089 NCBI chr19:5,775,829...5,803,260
Ensembl chr19:5,773,225...5,785,422 		JBrowse link
G CTH cystathionine gamma-lyase ISO SMPDB SMP:00033 NCBI chr20:62,672,820...62,718,608
Ensembl chr20:62,690,906...62,718,980 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO SMPDB
RGD		 PMID:12473678 PMID:22342103 RGD:1359078 RGD:7242551 SMP:00033 NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO RGD PMID:22342103 RGD:7242551 NCBI chr14:82,313,414...82,427,170
Ensembl chr14:82,402,826...82,420,819 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO RGD PMID:22342103 RGD:7242551 NCBI chr 2:37,128,635...37,176,033
Ensembl chr 2:37,146,538...37,174,570 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase ISO RGD PMID:12628190 PMID:22194015 RGD:1359080 RGD:7242554 NCBI chr 6:1,962,077...2,030,732
Ensembl chr 6:1,962,279...2,026,455 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:22194015 RGD:7242554 NCBI chr21:117,380,518...117,515,224
Ensembl chr21:117,380,361...117,421,573 		JBrowse link
G GAMT guanidinoacetate N-methyltransferase ISO RGD PMID:15533043 RGD:1359081 NCBI chr 6:1,165,016...1,178,458
Ensembl chr 6:1,164,259...1,178,354 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:15347642 PMID:22342103 PMID:23073625 RGD:1359070 RGD:7242425 RGD:7242551 NCBI chr17:29,196,142...29,199,728
Ensembl chr17:29,196,321...29,198,947 		JBrowse link
G HNMT histamine N-methyltransferase ISO RGD PMID:11566133 RGD:1359041 NCBI chr10:22,188,151...22,238,665
Ensembl chr10:22,188,110...22,238,671 		JBrowse link
G IL4I1 interleukin 4 induced 1 ISO SMPDB SMP:00033 NCBI chr 6:43,046,357...43,061,295
Ensembl chr 6:43,046,379...43,057,851 		JBrowse link
G KMT5A lysine methyltransferase 5A ISO RGD PMID:22194015 RGD:7242554 NCBI chr11:118,712,964...118,743,322
Ensembl chr11:118,723,029...118,743,325 		JBrowse link
G LOC103221104 cystathionine beta-synthase ISO SMPDB SMP:00033 NCBI chr 2:86,905,104...86,933,780 JBrowse link
G LOC103232876 acetylserotonin O-methyltransferase ISO RGD PMID:12198599 RGD:1359073 NCBI chr  X:1,838...12,924 JBrowse link
G LOC103244929 methionine adenosyltransferase 2 subunit beta ISO RGD
SMPDB		 PMID:23073625 RGD:7242425 SMP:00033 NCBI chr23:65,776,808...65,792,871
Ensembl chr23:65,779,437...65,792,369 		JBrowse link
G MARS1 methionyl-tRNA synthetase 1 ISO SMPDB SMP:00033 NCBI chr11:53,397,380...53,410,596 JBrowse link
G MAT1A methionine adenosyltransferase 1A ISO RGD PMID:2292587 PMID:9202427 PMID:23073625 RGD:1359039 RGD:7242425 RGD:7242932 NCBI chr 9:51,540,162...51,558,076
Ensembl chr 9:51,540,162...51,558,576 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO RGD
SMPDB		 PMID:11099469 PMID:23073625 RGD:1359040 RGD:7242425 SMP:00033 NCBI chr14:21,609,533...21,615,822
Ensembl chr14:21,611,040...21,615,615 		JBrowse link
G MRM2 mitochondrial rRNA methyltransferase 2 ISO RGD PMID:11827451 RGD:1359074 NCBI chr28:19,336,935...19,355,221 JBrowse link
G MSRB2 methionine sulfoxide reductase B2 ISO SMPDB SMP:00033 NCBI chr 9:22,863,029...22,890,765
Ensembl chr 9:22,863,184...22,889,644 		JBrowse link
G MSRB3 methionine sulfoxide reductase B3 ISO SMPDB SMP:00033 NCBI chr11:60,970,103...61,157,950
Ensembl chr11:60,969,985...61,154,356 		JBrowse link
G MTAP methylthioadenosine phosphorylase ISO RGD
SMPDB		 PMID:2292587 RGD:7242932 SMP:00033 NCBI chr15:84,196,548...84,198,357
Ensembl chr12:57,997,427...58,050,241 		JBrowse link
G MTFMT mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00033 NCBI chr26:18,556,747...18,583,528
Ensembl chr26:18,556,791...18,583,446 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD
SMPDB		 PMID:11933257 RGD:1535021 SMP:00033 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD
SMPDB		 PMID:15845641 PMID:20814827 PMID:23073625 RGD:1359026 RGD:7242425 RGD:7242426 SMP:00033 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 PMID:20814827 RGD:1359037 RGD:7242426 NCBI chr 4:7,461,521...7,493,032
Ensembl chr 4:7,461,526...7,493,840 		JBrowse link
G NNMT nicotinamide N-methyltransferase ISO RGD PMID:15922112 RGD:1359084 NCBI chr 1:105,650,178...105,708,441
Ensembl chr 1:105,690,085...105,713,010 		JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO RGD PMID:8263531 RGD:729481 NCBI chr13:21,808,583...21,867,309
Ensembl chr13:21,807,710...21,866,768 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO RGD PMID:8344945 RGD:729486 NCBI chr16:16,540,096...16,626,251
Ensembl chr16:16,539,985...16,611,279 		JBrowse link
G PNMT phenylethanolamine N-methyltransferase ISO RGD PMID:12438084 RGD:1359087 NCBI chr16:66,496,290...66,498,840
Ensembl chr16:66,496,027...66,499,111 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044 RGD:7242552 NCBI chr 6:42,854,873...42,863,113
Ensembl chr 6:42,854,918...42,863,014 		JBrowse link
G PRMT2 protein arginine methyltransferase 2 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 2:90,225,051...90,256,541
Ensembl chr 2:90,225,346...90,256,558 		JBrowse link
G PRMT3 protein arginine methyltransferase 3 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 1:44,486,165...44,621,002
Ensembl chr 1:44,485,880...44,620,936 		JBrowse link
G PRMT5 protein arginine methyltransferase 5 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044 RGD:7242552 NCBI chr29:23,288,458...23,297,746
Ensembl chr29:23,288,835...23,297,518 		JBrowse link
G PRMT6 protein arginine methyltransferase 6 ISO RGD PMID:15866169 PMID:21074527 RGD:1359044 RGD:7242552 NCBI chr20:26,547,305...26,551,327
Ensembl chr20:26,550,130...26,551,257 		JBrowse link
G PRMT7 protein arginine methyltransferase 7 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 5:59,058,827...59,106,177
Ensembl chr 5:59,058,846...59,106,106 		JBrowse link
G RNMT RNA guanine-7 methyltransferase ISO RGD PMID:11472630 RGD:1359071 NCBI chr18:72,203,405...72,242,527
Ensembl chr18:72,208,648...72,243,940 		JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr 7:86,476,101...86,528,146
Ensembl chr 7:86,481,726...86,527,779 		JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 ISO RGD PMID:11959841 RGD:1359072
G SHMT1 serine hydroxymethyltransferase 1 ISO SMPDB SMP:00033 NCBI chr16:17,371,704...17,408,499 JBrowse link
G SMS spermine synthase ISO RGD PMID:23073625 RGD:7242425 NCBI chr  X:20,418,435...20,475,227
Ensembl chr  X:20,418,494...20,476,276 		JBrowse link
G SMYD2 SET and MYND domain containing 2 ISO RGD PMID:22194015 RGD:7242554 NCBI chr25:15,236,773...15,293,154
Ensembl chr25:15,235,653...15,293,153 		JBrowse link
G SRM spermidine synthase ISO RGD
SMPDB		 PMID:23073625 RGD:7242425 SMP:00033 NCBI chr20:120,718,265...120,723,694
Ensembl chr20:120,718,424...120,723,944 		JBrowse link
G SUV39H1 SUV39H1 histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr  X:45,820,114...45,834,727
Ensembl chr  X:45,822,453...45,834,917 		JBrowse link
G SUV39H2 SUV39H2 histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr 9:14,900,503...14,924,017
Ensembl chr 9:14,900,945...14,923,447 		JBrowse link
polyamine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD PMID:10430362 PMID:13678416 RGD:1578320 RGD:7244193 NCBI chr13:62,977,659...62,999,150 JBrowse link
G AZIN1 antizyme inhibitor 1 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 8:97,679,775...97,717,486
Ensembl chr 8:97,679,468...97,696,928 		JBrowse link
G OAZ1 ornithine decarboxylase antizyme 1 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 6:2,061,774...2,065,595
Ensembl chr 6:2,061,811...2,065,265 		JBrowse link
G OAZ2 ornithine decarboxylase antizyme 2 ISO RGD PMID:21849468 RGD:7244195 NCBI chr26:18,881,776...18,897,043
Ensembl chr26:18,881,831...18,895,915 		JBrowse link
G OAZ3 ornithine decarboxylase antizyme 3 ISO RGD PMID:21849468 RGD:7244195 NCBI chr20:11,916,163...11,922,770 JBrowse link
G ODC1 ornithine decarboxylase 1 ISO RGD PMID:10430362 PMID:13678416 RGD:1578320 RGD:7244193 NCBI chr14:97,173,338...97,182,253 JBrowse link
G PAOX polyamine oxidase ISO RGD PMID:13678416 PMID:15541750 RGD:7244190 RGD:7244193 NCBI chr26:53,228,320...53,238,362
Ensembl chr26:53,228,396...53,240,508 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:13678416 PMID:15541750 RGD:7244190 RGD:7244193 NCBI chr  X:22,231,915...22,234,981
Ensembl chr  X:22,231,855...22,235,031 		JBrowse link
G SMOX spermine oxidase ISO RGD PMID:13678416 PMID:15541750 RGD:7244190 RGD:7244193
G SMS spermine synthase ISO RGD PMID:13678416 RGD:7244193 NCBI chr  X:20,418,435...20,475,227
Ensembl chr  X:20,418,494...20,476,276 		JBrowse link
G SRM spermidine synthase ISO RGD PMID:13678416 RGD:7244193 NCBI chr20:120,718,265...120,723,694
Ensembl chr20:120,718,424...120,723,944 		JBrowse link
putrescine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD PMID:10430362 RGD:1578320 NCBI chr13:62,977,659...62,999,150 JBrowse link
G ODC1 ornithine decarboxylase 1 ISO RGD PMID:10430362 RGD:1578320 NCBI chr14:97,173,338...97,182,253 JBrowse link
remethylation pathway of homocysteine metabolism - cobalamin dependent term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 PMID:20814827 RGD:1359026 RGD:7242426 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 PMID:20814827 RGD:1359037 RGD:7242426 NCBI chr 4:7,461,521...7,493,032
Ensembl chr 4:7,461,526...7,493,840 		JBrowse link
remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependent term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase ISO SMPDB SMP:00123 NCBI chr 2:38,579,254...38,601,218
Ensembl chr 2:38,579,024...38,601,208 		JBrowse link
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 ISO SMPDB SMP:00123 NCBI chr23:29,539,897...29,589,004 JBrowse link
G BHMT betaine--homocysteine S-methyltransferase ISO RGD
SMPDB		 PMID:15845641 PMID:20346934 PMID:20814827 RGD:1359026 RGD:7242426 RGD:7242428 SMP:00123 NCBI chr 4:73,331,551...73,352,259
Ensembl chr 4:73,332,259...73,352,434 		JBrowse link
G CHDH choline dehydrogenase ISO SMPDB SMP:00123 NCBI chr22:15,197,568...15,228,613
Ensembl chr22:15,197,170...15,205,352 		JBrowse link
G LOC103244929 methionine adenosyltransferase 2 subunit beta ISO SMPDB SMP:00123 NCBI chr23:65,776,808...65,792,871
Ensembl chr23:65,779,437...65,792,369 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO SMPDB SMP:00123 NCBI chr14:21,609,533...21,615,822
Ensembl chr14:21,611,040...21,615,615 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO SMPDB SMP:00123 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO SMPDB SMP:00123 NCBI chr16:16,540,096...16,626,251
Ensembl chr16:16,539,985...16,611,279 		JBrowse link
spermidine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO SMPDB
RGD		 PMID:1415709 PMID:10430362 PMID:10712236 RGD:1578320 RGD:7242911 RGD:7242912 SMP:00445 NCBI chr13:62,977,659...62,999,150 JBrowse link
G LOC103244929 methionine adenosyltransferase 2 subunit beta ISO SMPDB SMP:00445 NCBI chr23:65,776,808...65,792,871
Ensembl chr23:65,779,437...65,792,369 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr14:21,609,533...21,615,822
Ensembl chr14:21,611,040...21,615,615 		JBrowse link
G ODC1 ornithine decarboxylase 1 ISO RGD
SMPDB		 PMID:1415709 PMID:2292587 PMID:10430362 RGD:1578320 RGD:7242912 RGD:7242932 SMP:00445 NCBI chr14:97,173,338...97,182,253 JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:2292587 RGD:7242932 NCBI chr  X:22,231,915...22,234,981
Ensembl chr  X:22,231,855...22,235,031 		JBrowse link
G SMS spermine synthase ISO SMPDB SMP:00445 NCBI chr  X:20,418,435...20,475,227
Ensembl chr  X:20,418,494...20,476,276 		JBrowse link
G SRM spermidine synthase ISO RGD
SMPDB		 PMID:2292587 PMID:16931179 PMID:23073625 RGD:7242425 RGD:7242920 RGD:7242932 SMP:00445 NCBI chr20:120,718,265...120,723,694
Ensembl chr20:120,718,424...120,723,944 		JBrowse link
spermine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD
SMPDB		 PMID:1415709 PMID:10430362 PMID:10712236 RGD:1578320 RGD:7242911 RGD:7242912 SMP:00445 NCBI chr13:62,977,659...62,999,150 JBrowse link
G LOC103244929 methionine adenosyltransferase 2 subunit beta ISO SMPDB SMP:00445 NCBI chr23:65,776,808...65,792,871
Ensembl chr23:65,779,437...65,792,369 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr14:21,609,533...21,615,822
Ensembl chr14:21,611,040...21,615,615 		JBrowse link
G ODC1 ornithine decarboxylase 1 ISO RGD
SMPDB		 PMID:1415709 PMID:2292587 PMID:10430362 RGD:1578320 RGD:7242912 RGD:7242932 SMP:00445 NCBI chr14:97,173,338...97,182,253 JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:2292587 RGD:7242932 NCBI chr  X:22,231,915...22,234,981
Ensembl chr  X:22,231,855...22,235,031 		JBrowse link
G SMS spermine synthase ISO SMPDB
RGD		 PMID:2292587 PMID:23073625 RGD:7242425 RGD:7242932 SMP:00445 NCBI chr  X:20,418,435...20,475,227
Ensembl chr  X:20,418,494...20,476,276 		JBrowse link
G SRM spermidine synthase ISO SMPDB SMP:00445 NCBI chr20:120,718,265...120,723,694
Ensembl chr20:120,718,424...120,723,944 		JBrowse link
transsulfuration pathway of homocysteine metabolism term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDO1 cysteine dioxygenase type 1 ISO RGD PMID:20162368 RGD:7242427 NCBI chr23:19,049,612...19,061,783
Ensembl chr23:19,049,262...19,061,740 		JBrowse link
G CSAD cysteine sulfinic acid decarboxylase ISO RGD PMID:20162368 RGD:7242427 NCBI chr11:49,256,629...49,288,367
Ensembl chr11:49,256,628...49,288,112 		JBrowse link
G CTH cystathionine gamma-lyase ISO SMPDB
RGD		 PMID:20162368 RGD:7242427 SMP:00455 NCBI chr20:62,672,820...62,718,608
Ensembl chr20:62,690,906...62,718,980 		JBrowse link
G LOC103221104 cystathionine beta-synthase ISO RGD
SMPDB		 PMID:20162368 RGD:7242427 SMP:00455 NCBI chr 2:86,905,104...86,933,780 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    regulatory pathway 2488
      homeostasis pathway 1295
        organic chemical homeostasis pathway 360
          S-adenosylmethionine homeostasis pathway 263
            DNA modification pathway + 28
            folate metabolic pathway + 30
            histone modification pathway + 172
            homocysteine metabolic pathway + 29
            methionine cycle/metabolic pathway + 51
            polyamine metabolic pathway + 13
            radical SAM enzyme mediated metabolic pathway + 0
paths to the root