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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:vinorelbine pharmacodynamics pathway
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Accession:PW:0001684 term browser browse the term
Definition:The pathway of vinorelbine-target interaction and of the biochemical or physiological responses to drug. The drug interacts with tubulin and disrupts microtubules function, particularly those at the mitotic spindle. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00439;   VRL pharmacodynamics pathway


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vinorelbine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A ISO SMPDB SMP:00439 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 ISO SMPDB SMP:00439 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc10 ATP-binding cassette, sub-family C member 10 ISO SMPDB SMP:00439 NCBI chr17:46,614,146...46,638,954
Ensembl chr17:46,614,147...46,639,278 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 ISO SMPDB SMP:00439 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 ISO SMPDB SMP:00439 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00439 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 ISO SMPDB SMP:00439 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB SMP:00439 NCBI chr17:66,155,410...66,192,750
Ensembl chr17:66,155,413...66,192,793 		JBrowse link
G Trp53 transformation related protein 53 ISO SMPDB SMP:00439 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tuba1b tubulin, alpha 1B ISO SMPDB SMP:00439 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446 		JBrowse link
G Tubb1 tubulin, beta 1 class VI ISO SMPDB SMP:00439 NCBI chr 2:174,292,388...174,300,173
Ensembl chr 2:174,292,488...174,299,675 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6072
    drug pathway 402
      antineoplastic and immunomodulatory drug pathway 159
        antineoplastic drug pathway 158
          vinca alkaloid drug pathway 11
            vinorelbine drug pathway 11
              vinorelbine pharmacodynamics pathway 11
paths to the root