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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:sarcosinemia pathway
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Accession:PW:0001670 term browser browse the term
Definition:A rare autosomal recessive metabolic disorder due to mutations in sarcosine dehydrogenase resulting in alterations of sarcosine metabolism.
Synonyms:exact_synonym: SARCOS pathway;   SARD deficiency pathway;   SARDH deficiency pathway;   SARDHD pathway;   hypersarcosinemia pathway;   sarcosine dehydrogenase complex deficiency pathway;   sarcosinemia disease pathway
 related_synonym: SMP:00244


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sarcosinemia pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGXT alanine--glyoxylate and serine--pyruvate aminotransferase ISO SMPDB SMP:00244 NCBI chr25:50,968,291...50,976,089 JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 ISO SMPDB SMP:00244 NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638
JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member ISO SMPDB SMP:00244 NCBI chr26:9,319,109...9,361,021 JBrowse link
G AMT aminomethyltransferase ISO SMPDB SMP:00244 NCBI chr20:39,815,449...39,820,907
Ensembl chr20:39,815,814...39,820,506
JBrowse link
G BHMT betaine--homocysteine S-methyltransferase ISO SMPDB SMP:00244 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046
JBrowse link
G CBS cystathionine beta-synthase ISO SMPDB SMP:00244 NCBI chr31:37,230,900...37,247,170 JBrowse link
G CTH cystathionine gamma-lyase ISO SMPDB SMP:00244 NCBI chr 6:75,324,328...75,348,476
Ensembl chr 6:75,324,787...75,349,451
JBrowse link
G DLD dihydrolipoamide dehydrogenase ISO SMPDB SMP:00244 NCBI chr18:12,703,340...12,734,408
Ensembl chr18:12,703,341...12,734,479
JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO SMPDB SMP:00244 NCBI chr 3:27,789,089...27,857,348
Ensembl chr 3:27,790,324...27,856,601
JBrowse link
G GAMT guanidinoacetate N-methyltransferase ISO SMPDB SMP:00244 NCBI chr20:57,440,698...57,442,588 JBrowse link
G GARS1 glycyl-tRNA synthetase 1 ISO SMPDB SMP:00244 NCBI chr14:43,308,274...43,351,999
Ensembl chr14:43,308,152...43,396,487
JBrowse link
G GATM glycine amidinotransferase ISO SMPDB SMP:00244 NCBI chr30:11,724,446...11,742,214
Ensembl chr30:11,723,519...11,742,214
JBrowse link
G GCAT glycine C-acetyltransferase ISO SMPDB SMP:00244 NCBI chr10:26,821,121...26,827,496
Ensembl chr10:26,821,027...26,827,707
JBrowse link
G GLDC glycine decarboxylase ISO SMPDB SMP:00244 NCBI chr11:27,491,639...27,584,450
Ensembl chr11:27,414,834...27,584,450
JBrowse link
G GLYCTK glycerate kinase ISO SMPDB SMP:00244 NCBI chr20:37,462,651...37,495,581
Ensembl chr20:37,462,659...37,465,807
JBrowse link
G GNMT glycine N-methyltransferase ISO SMPDB SMP:00244 NCBI chr12:11,500,363...11,503,075
Ensembl chr12:11,500,392...11,503,481
JBrowse link
G MAOA monoamine oxidase A ISO SMPDB SMP:00244 NCBI chr  X:37,678,933...37,744,757
Ensembl chr  X:37,677,493...37,744,757
JBrowse link
G PHGDH phosphoglycerate dehydrogenase ISO SMPDB SMP:00244 NCBI chr17:56,806,912...56,833,765 JBrowse link
G PSAT1 phosphoserine aminotransferase 1 ISO SMPDB SMP:00244 NCBI chr 1:80,376,469...80,408,177
Ensembl chr 1:80,377,115...80,408,162
JBrowse link
G PSPH phosphoserine phosphatase ISO SMPDB SMP:00244 NCBI chr 6:493,152...546,176
Ensembl chr 6:493,176...512,089
JBrowse link
G SARDH sarcosine dehydrogenase ISO SMPDB SMP:00244 NCBI chr 9:50,030,397...50,093,556
Ensembl chr 9:50,030,707...50,091,553
JBrowse link
G SARS1 seryl-tRNA synthetase 1 ISO SMPDB SMP:00244 NCBI chr 6:42,584,792...42,605,201
Ensembl chr 6:42,584,798...42,605,136
JBrowse link
G SDS serine dehydratase ISO SMPDB SMP:00244 NCBI chr26:10,725,123...10,728,087 JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO SMPDB SMP:00244 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166
JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO SMPDB SMP:00244 NCBI chr10:1,357,347...1,362,511
Ensembl chr10:1,356,706...1,362,305
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4033
    disease pathway 714
      nutritional and metabolic disease pathway 573
        metabolic disease pathway 533
          mitochondrial disease pathway 80
            sarcosinemia pathway 25
Path 2
Term Annotations click to browse term
  pathway 4033
    disease pathway 714
      nutritional and metabolic disease pathway 573
        metabolic disease pathway 533
          inborn error of metabolism pathway 517
            inborn error of amino acid metabolism pathway 228
              sarcosinemia pathway 25
paths to the root