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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:amlodipine pharmacodynamics pathway
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Accession:PW:0001661 term browser browse the term
Definition:The pathway of amlodipine-target interaction and of the biochemical or physiological responses to drug. Amlodipine, a calcium channel blocker is used to lower blood pressure. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00376


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amlodipine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00376 NCBI chrNW_004936528:1,608,782...1,682,873 JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00376 NCBI chrNW_004936548:4,983,461...5,110,693 JBrowse link
G Adrb1 adrenoceptor beta 1 ISO SMPDB SMP:00376 NCBI chrNW_004936486:4,400,467...4,401,588 JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO SMPDB SMP:00376 NCBI chrNW_004936519:6,831,096...6,873,977 JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00376 NCBI chrNW_004936627:1,555,151...1,584,370 JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00376 NCBI chrNW_004936706:476,473...494,659 JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00376 NCBI chrNW_004936740:445,952...478,580 JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00376 NCBI chrNW_004936481:17,438,146...17,460,329 JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00376 NCBI chrNW_004936595:908,019...914,426 JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00376 NCBI chrNW_004936540:3,621,656...3,640,885 JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00376 NCBI chrNW_004936479:9,648,315...9,666,782 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00376 NCBI chrNW_004936558:3,300,941...3,357,595 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00376 NCBI chrNW_004936606:2,168,104...2,867,560 JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00376 NCBI chrNW_004936490:11,093,600...11,157,756 JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00376 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00376 NCBI chrNW_004936529:1,889,811...2,023,710 JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00376 NCBI chrNW_004936490:14,448,305...14,468,785 JBrowse link
G Chrm2 cholinergic receptor muscarinic 2 ISO SMPDB SMP:00376 NCBI chrNW_004936592:1,396,939...1,525,255 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00376 NCBI chrNW_004936833:551,989...843,064 JBrowse link
G Fxyd2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00376 NCBI chrNW_004936542:2,956,784...2,961,076 JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO SMPDB SMP:00376 NCBI chrNW_004936471:32,527,551...32,570,548 JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 ISO SMPDB SMP:00376 NCBI chrNW_004936577:3,896,455...4,198,396 JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00376 NCBI chrNW_004936690:417,907...627,025 JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00376 NCBI chrNW_004936500:7,998,464...8,007,848 JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00376 NCBI chrNW_004936500:8,067,009...8,072,383 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00376 NCBI chrNW_004936527:6,380,222...6,412,390 JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00376 NCBI chrNW_004936600:3,940,806...3,974,455 JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 ISO SMPDB SMP:00376 NCBI chrNW_004936528:1,685,015...1,688,220 JBrowse link
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 ISO SMPDB SMP:00376 NCBI chrNW_004936655:3,447,026...3,459,569 JBrowse link
G Kcnj3 potassium inwardly rectifying channel subfamily J member 3 ISO SMPDB SMP:00376 NCBI chrNW_004936469:23,163,057...23,304,178 JBrowse link
G Kcnj4 potassium inwardly rectifying channel subfamily J member 4 ISO SMPDB SMP:00376 NCBI chrNW_004936492:2,865,803...2,867,657 JBrowse link
G Kcnj5 potassium inwardly rectifying channel subfamily J member 5 ISO SMPDB SMP:00376 NCBI chrNW_004936572:3,344,942...3,373,690 JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 ISO SMPDB SMP:00376 NCBI chrNW_004936548:5,125,583...5,132,490 JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00376 NCBI chrNW_004936484:18,186,184...18,221,304 JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00376 NCBI chrNW_004936794:707,122...994,206 JBrowse link
G LOC101966570 sodium/potassium-transporting ATPase subunit alpha-2 ISO SMPDB SMP:00376 NCBI chrNW_004936740:489,357...514,235 JBrowse link
G LOC101967074 calmodulin ISO SMPDB SMP:00376 NCBI chrNW_004936488:17,580,425...17,588,480 JBrowse link
G Mylk myosin light chain kinase ISO SMPDB SMP:00376 NCBI chrNW_004936725:1,418,930...1,594,697 JBrowse link
G Plcb1 phospholipase C beta 1 ISO SMPDB SMP:00376 NCBI chrNW_004936485:10,548,966...11,254,139 JBrowse link
G Pln phospholamban ISO SMPDB SMP:00376 NCBI chrNW_004936658:1,443,626...1,453,770 JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00376 NCBI chrNW_004936659:2,750,015...2,765,914 JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00376 NCBI chrNW_004936541:7,845,876...7,863,677 JBrowse link
G Ryr2 ryanodine receptor 2 ISO SMPDB SMP:00376 NCBI chrNW_004936484:15,402,488...15,825,410 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00376 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO SMPDB SMP:00376 NCBI chrNW_004936508:10,894,918...11,256,084 JBrowse link
G Snta1 syntrophin alpha 1 ISO SMPDB SMP:00376 NCBI chrNW_004936561:7,101,654...7,134,529 JBrowse link
G Sntb1 syntrophin beta 1 ISO SMPDB SMP:00376 NCBI chrNW_004936470:26,074,175...26,301,076 JBrowse link
G Sntb2 syntrophin beta 2 ISO SMPDB SMP:00376 NCBI chrNW_004936475:19,335,584...19,425,642 JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00376 NCBI chrNW_004936473:3,290,961...3,293,920 JBrowse link
G Tnnc2 troponin C2, fast skeletal type ISO SMPDB SMP:00376 NCBI chrNW_004936514:7,196,576...7,199,603 JBrowse link
G Tnni1 troponin I1, slow skeletal type ISO SMPDB SMP:00376 NCBI chrNW_004936567:3,013,359...3,025,137 JBrowse link
G Tnni2 troponin I2, fast skeletal type ISO SMPDB SMP:00376 NCBI chrNW_004936816:738,754...741,328 JBrowse link
G Tnni3 troponin I3, cardiac type ISO SMPDB SMP:00376 NCBI chrNW_004936886:437,754...440,925 JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO SMPDB SMP:00376 NCBI chrNW_004936886:425,331...434,546 JBrowse link
G Tnnt2 troponin T2, cardiac type ISO SMPDB SMP:00376 NCBI chrNW_004936567:3,052,167...3,069,077 JBrowse link
G Tnnt3 troponin T3, fast skeletal type ISO SMPDB SMP:00376 NCBI chrNW_004936816:805,360...822,044 JBrowse link
G Tpm1 tropomyosin 1 ISO SMPDB SMP:00376 NCBI chrNW_004936471:23,643,645...23,670,775 JBrowse link
G Tpm2 tropomyosin 2 ISO SMPDB SMP:00376 NCBI chrNW_004936524:3,679,719...3,687,828 JBrowse link

Term paths to the root
Path 1
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  pathway 3930
    drug pathway 357
      cardiovascular system drug pathway 165
        calcium channel blocker drug pathway 58
          dihydropyridine calcium channel blocker drug pathway 58
            amlodipine drug pathway 58
              amlodipine pharmacodynamics pathway 58
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.