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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:adefovir drug pathway
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Accession:PW:0001616 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of adefovir, an anti-viral drug used for the treatment of hepatitis B. It is administered as adefovir dipivoxil prodrug. Once metabolized, it acts as a nucleotide analog reverse transcriptase inhibitor.


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adefovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AK1 adenylate kinase 1 ISO SMPDB SMP:00629 NCBI chr 1:268,355,032...268,365,659
Ensembl chr 1:268,355,033...268,365,598 		JBrowse link
G AK2 adenylate kinase 2 ISO SMPDB SMP:00629 NCBI chr 6:89,295,164...89,318,169 JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00629 NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140 		JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 ISO SMPDB SMP:00629 NCBI chr12:27,439,529...27,445,025
Ensembl chr12:27,439,260...27,445,027 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4041
    drug pathway 384
      anti-infective drug pathway 25
        adefovir drug pathway 4
          adefovir pharmacodynamics pathway 0
          adefovir pharmacokinetics pathway 4
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