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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:adefovir drug pathway
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Accession:PW:0001616 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of adefovir, an anti-viral drug used for the treatment of hepatitis B. It is administered as adefovir dipivoxil prodrug. Once metabolized, it acts as a nucleotide analog reverse transcriptase inhibitor.


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adefovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AK1 adenylate kinase 1 EXP SMPDB SMP:00629 NCBI chr 9:127,866,480...127,879,621
Ensembl chr 9:127,866,486...127,877,675 		JBrowse link
G AK2 adenylate kinase 2 EXP SMPDB SMP:00629 NCBI chr 1:33,007,940...33,036,883
Ensembl chr 1:33,007,986...33,080,996 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 EXP SMPDB SMP:00629 NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428 		JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 EXP SMPDB SMP:00629 NCBI chr17:51,165,536...51,171,744
Ensembl chr17:51,165,435...51,171,744 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    drug pathway 412
      anti-infective drug pathway 29
        adefovir drug pathway 4
          adefovir pharmacodynamics pathway 0
          adefovir pharmacokinetics pathway 4
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