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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:adefovir drug pathway
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Accession:PW:0001616 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of adefovir, an anti-viral drug used for the treatment of hepatitis B. It is administered as adefovir dipivoxil prodrug. Once metabolized, it acts as a nucleotide analog reverse transcriptase inhibitor.



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adefovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AK1 adenylate kinase 1 ISO SMPDB SMP:00629 NCBI chr 9:98,987,348...98,997,252
Ensembl chr 9:127,657,338...127,678,245
JBrowse link
G AK2 adenylate kinase 2 ISO SMPDB SMP:00629 NCBI chr 1:32,295,668...32,323,681
Ensembl chr 1:33,480,947...33,508,621
JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00629 NCBI chr17:45,243,588...45,252,135
Ensembl chr17:50,113,622...50,131,636
JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 ISO SMPDB SMP:00629 NCBI chr17:45,255,982...45,261,541 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    drug pathway 395
      anti-infective drug pathway 28
        adefovir drug pathway 4
          adefovir pharmacodynamics pathway 0
          adefovir pharmacokinetics pathway 4
paths to the root