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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:tyrosinemia pathway
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Accession:PW:0001607 term browser browse the term
Definition:A group of disorders due to inborn errors of the tyrosine metabolic pathway. The three types of tyrosinemia are caused by deficiencies in distinct enzymes of the tyrosine degradation pathway and exhibit specific phenotypes.
Synonyms:exact_synonym: tyrosinemia disease pathway


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tyrosinemia type I pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide EXP SMPDB SMP:00218 NCBI chr 4:99,276,369...99,290,985
Ensembl chr 4:99,276,369...99,291,003 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 EXP SMPDB SMP:00218 NCBI chr17:19,737,984...19,748,298
Ensembl chr17:19,737,984...19,748,943 		JBrowse link
G AOC1 amine oxidase copper containing 1 EXP SMPDB SMP:00218 NCBI chr 7:150,852,120...150,861,504
Ensembl chr 7:150,824,627...150,861,504 		JBrowse link
G COMT catechol-O-methyltransferase EXP SMPDB SMP:00218 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G DBH dopamine beta-hydroxylase EXP SMPDB SMP:00218 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G DCT dopachrome tautomerase EXP SMPDB SMP:00218 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682 		JBrowse link
G DDC dopa decarboxylase EXP SMPDB SMP:00218 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405 		JBrowse link
G FAH fumarylacetoacetate hydrolase EXP SMPDB SMP:00218 NCBI chr15:80,152,789...80,186,949
Ensembl chr15:80,152,490...80,186,946 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 EXP SMPDB SMP:00218 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 EXP SMPDB SMP:00218 NCBI chr14:77,321,036...77,331,597
Ensembl chr14:77,320,996...77,331,597 		JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase EXP SMPDB SMP:00218 NCBI chr 2:42,767,089...42,792,583
Ensembl chr 2:42,767,089...42,792,593 		JBrowse link
G HGD homogentisate 1,2-dioxygenase EXP SMPDB SMP:00218 NCBI chr 3:120,628,172...120,682,239
Ensembl chr 3:120,628,172...120,682,269 		JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase EXP SMPDB SMP:00218 NCBI chr12:121,839,527...121,888,611
Ensembl chr12:121,839,527...121,863,596 		JBrowse link
G MAOA monoamine oxidase A EXP SMPDB SMP:00218 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G MIF macrophage migration inhibitory factor EXP SMPDB SMP:00218 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227 		JBrowse link
G PNMT phenylethanolamine N-methyltransferase EXP SMPDB SMP:00218 NCBI chr17:39,668,019...39,670,475
Ensembl chr17:39,667,981...39,670,475 		JBrowse link
G TAT tyrosine aminotransferase EXP SMPDB SMP:00218 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092 		JBrowse link
G TYR tyrosinase EXP SMPDB SMP:00218 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
tyrosinemia type II pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAH fumarylacetoacetate hydrolase EXP SMPDB SMP:00369 NCBI chr15:80,152,789...80,186,949
Ensembl chr15:80,152,490...80,186,946 		JBrowse link
G FARSA phenylalanyl-tRNA synthetase subunit alpha EXP SMPDB SMP:00369 NCBI chr19:12,922,479...12,933,711
Ensembl chr19:12,922,479...12,934,037 		JBrowse link
G FARSB phenylalanyl-tRNA synthetase subunit beta EXP SMPDB SMP:00369 NCBI chr 2:222,566,899...222,656,092
Ensembl chr 2:222,566,899...222,656,092 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 EXP SMPDB SMP:00369 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 EXP SMPDB SMP:00369 NCBI chr14:77,321,036...77,331,597
Ensembl chr14:77,320,996...77,331,597 		JBrowse link
G HGD homogentisate 1,2-dioxygenase EXP SMPDB SMP:00369 NCBI chr 3:120,628,172...120,682,239
Ensembl chr 3:120,628,172...120,682,269 		JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase EXP SMPDB SMP:00369 NCBI chr12:121,839,527...121,888,611
Ensembl chr12:121,839,527...121,863,596 		JBrowse link
G IL4I1 interleukin 4 induced 1 EXP SMPDB SMP:00369 NCBI chr19:49,889,654...49,929,504
Ensembl chr19:49,889,654...49,929,539 		JBrowse link
G PAH phenylalanine hydroxylase EXP SMPDB SMP:00369 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410 		JBrowse link
G TAT tyrosine aminotransferase EXP SMPDB SMP:00369 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092 		JBrowse link
G YARS1 tyrosyl-tRNA synthetase 1 EXP SMPDB SMP:00369 NCBI chr 1:32,775,239...32,817,358
Ensembl chr 1:32,775,237...32,818,031 		JBrowse link
tyrosinemia type III pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 EXP SMPDB SMP:00434 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) EXP SMPDB SMP:00434 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 EXP SMPDB SMP:00434 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) EXP SMPDB SMP:00434 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G FAH fumarylacetoacetate hydrolase EXP SMPDB SMP:00370 NCBI chr15:80,152,789...80,186,949
Ensembl chr15:80,152,490...80,186,946 		JBrowse link
G FARSA phenylalanyl-tRNA synthetase subunit alpha EXP SMPDB SMP:00370 NCBI chr19:12,922,479...12,933,711
Ensembl chr19:12,922,479...12,934,037 		JBrowse link
G FARSB phenylalanyl-tRNA synthetase subunit beta EXP SMPDB SMP:00370 NCBI chr 2:222,566,899...222,656,092
Ensembl chr 2:222,566,899...222,656,092 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 EXP SMPDB SMP:00370 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 EXP SMPDB SMP:00370 NCBI chr14:77,321,036...77,331,597
Ensembl chr14:77,320,996...77,331,597 		JBrowse link
G HGD homogentisate 1,2-dioxygenase EXP SMPDB SMP:00370 NCBI chr 3:120,628,172...120,682,239
Ensembl chr 3:120,628,172...120,682,269 		JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase EXP SMPDB SMP:00370 NCBI chr12:121,839,527...121,888,611
Ensembl chr12:121,839,527...121,863,596 		JBrowse link
G IL4I1 interleukin 4 induced 1 EXP SMPDB SMP:00370 NCBI chr19:49,889,654...49,929,504
Ensembl chr19:49,889,654...49,929,539 		JBrowse link
G PAH phenylalanine hydroxylase EXP SMPDB SMP:00370 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410 		JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 EXP SMPDB SMP:00434 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911 		JBrowse link
G TAT tyrosine aminotransferase EXP SMPDB SMP:00370 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092 		JBrowse link
G TUBA1B tubulin alpha 1b EXP SMPDB SMP:00434 NCBI chr12:49,127,782...49,131,395
Ensembl chr12:49,127,782...49,131,397 		JBrowse link
G TUBB1 tubulin beta 1 class VI EXP SMPDB SMP:00434 NCBI chr20:59,016,438...59,026,654
Ensembl chr20:59,019,429...59,026,654 		JBrowse link
G YARS1 tyrosyl-tRNA synthetase 1 EXP SMPDB SMP:00370 NCBI chr 1:32,775,239...32,817,358
Ensembl chr 1:32,775,237...32,818,031 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5958
    disease pathway 2076
      nervous system disease pathway 768
        brain disease pathway 353
          inborn error of brain metabolic pathway 322
            tyrosinemia pathway 30
              tyrosinemia type I pathway 18
              tyrosinemia type II pathway 11
              tyrosinemia type III pathway 18
Path 2
Term Annotations click to browse term
  pathway 5958
    disease pathway 2076
      nutritional and metabolic disease pathway 694
        metabolic disease pathway 650
          inborn error of metabolism pathway 536
            inborn error of amino acid metabolism pathway 232
              tyrosinemia pathway 30
                tyrosinemia type I pathway 18
                tyrosinemia type II pathway 11
                tyrosinemia type III pathway 18
paths to the root