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ONTOLOGY REPORT - ANNOTATIONS


Term:doxorubicin pharmacodynamics pathway
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Accession:PW:0001566 term browser browse the term
Definition:The pathway of doxorubicin-target interaction and of the biochemical or physiological responses to drug. Doxorubicin is used as a chemotherapeutic agent for the treatment of many cancers. Its use is restricted by the serious cardiotoxic effects it exerts. Genetic variations can cause differences in the response of the organism to the drug.

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doxorubicin pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TOP2A DNA topoisomerase II alpha JBrowse link 17 40,388,525 40,417,902 RGD:10395260
G TOP2B DNA topoisomerase II beta JBrowse link 3 25,597,905 25,664,907 RGD:10395260

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  pathway 5951
    drug pathway 412
      antineoplastic and immunomodulatory drug pathway 160
        antineoplastic drug pathway 159
          doxorubicin drug pathway 20
            doxorubicin pharmacodynamics pathway 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.