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ONTOLOGY REPORT - ANNOTATIONS


Term:polyol pathway
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Accession:PW:0001520 term browser browse the term
Definition:The polyol pathway is triggered by excess glucose which is reduced to sorbitol in the first step which requires NADPH as a cofactor. Sorbitol is eventually converted to fructose. Sorbitol, which is membrane impermeable and metabolites of fructose which can lead to the production of AGEs (advance glycation endproduct), along with other pathways affected by a hyperglycemic state are thought to be associated with the pathophysiology of diabetic retinopathy. The intermediate sorbitol in the pathway is a sugar alcohol; sugar alcohols are a class of polyols - alcohol molecules with multiple hydroxyl groups.
Synonyms:related_synonym: sorbitol-aldose reductase pathway
 alt_id: PW:0001518


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polyol pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link NW_004936579 1,312,175 1,328,397 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 2243
    classic metabolic pathway 699
      carbohydrate metabolic pathway 181
        polyol pathway 1
Path 2
Term Annotations click to browse term
  pathway 2243
    regulatory pathway 944
      homeostasis pathway 568
        glucose homeostasis pathway 159
          glucose utilization pathway 55
            glucose reduction pathway 1
              polyol pathway 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.