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Term:polyol pathway
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Accession:PW:0001520 term browser browse the term
Definition:The polyol pathway is triggered by excess glucose which is reduced to sorbitol in the first step which requires NADPH as a cofactor. Sorbitol is eventually converted to fructose. Sorbitol, which is membrane impermeable and metabolites of fructose which can lead to the production of AGEs (advance glycation endproduct), along with other pathways affected by a hyperglycemic state are thought to be associated with the pathophysiology of diabetic retinopathy. The intermediate sorbitol in the pathway is a sugar alcohol; sugar alcohols are a class of polyols - alcohol molecules with multiple hydroxyl groups.
Synonyms:related_synonym: sorbitol-aldose reductase pathway
 alt_id: PW:0001518

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polyol pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:8549559

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6063
    classic metabolic pathway 1852
      carbohydrate metabolic pathway 525
        polyol pathway 1
Path 2
Term Annotations click to browse term
  pathway 6063
    regulatory pathway 3842
      homeostasis pathway 1761
        glucose homeostasis pathway 344
          glucose utilization pathway 121
            glucose reduction pathway 1
              polyol pathway 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.