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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:kinin signaling pathway
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Accession:PW:0001480 term browser browse the term
Definition:The active kinin peptides generated by the kallikrein-kinin cascade - bradykinin, kallidin and their C-terminal processed metabolites, signal via two G-protein coupled (GPCR) receptors. The two receptors employ similar signaling pathways but also exhibit distinct patterns. Type 1 receptor is inducible, type 2 is ubiquitous and can form heterodimers with angiotensin II receptors.
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kinin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB1 arrestin beta 1 ISO RGD PMID:21145390 RGD:7411621 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:21145390 RGD:7411621 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:15734727 PMID:16177542 RGD:7401223 RGD:7401225 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BDKRB2 bradykinin receptor B2 ISO RGD PMID:15734727 PMID:16177542 RGD:7401223 RGD:7401225 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15734727 RGD:7401225 NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094 		JBrowse link
G KNG1 kininogen 1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    signaling pathway 1942
      signaling pathway pertinent to immunity 422
        kallikrein-kinin cascade pathway 19
          kinin signaling pathway 6
Path 2
Term Annotations click to browse term
  pathway 4069
    signaling pathway 1942
      signaling pathway pertinent to the brain and nervous system 232
        sensory system signaling pathway 70
          kallikrein-kinin cascade pathway 19
            kinin signaling pathway 6
paths to the root