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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.

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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00649 NCBI chrNW_004936763:1,225,355...1,308,257
Ensembl chrNW_004936763:1,226,482...1,297,427 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00649 NCBI chrNW_004936501:3,400,971...3,467,061
Ensembl chrNW_004936501:3,401,285...3,470,460 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chrNW_004936636:292,631...341,999
Ensembl chrNW_004936636:292,709...340,393 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 NCBI chrNW_004936490:11,039,968...11,086,670
Ensembl chrNW_004936490:11,040,445...11,086,566 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00649 NCBI chrNW_004936472:14,396,986...14,624,597
Ensembl chrNW_004936472:14,397,222...14,624,648 		JBrowse link
G Chpt1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chrNW_004936492:12,325,332...12,358,521
Ensembl chrNW_004936492:12,326,636...12,358,527 		JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chrNW_004936474:28,147,459...28,180,779
Ensembl chrNW_004936474:28,147,085...28,182,043 		JBrowse link
G Dck deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chrNW_004936598:3,819,239...3,846,692
Ensembl chrNW_004936598:3,817,994...3,843,241 		JBrowse link
G Nt5c 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chrNW_004936594:430,274...432,027
Ensembl chrNW_004936594:430,506...432,095 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chrNW_004936784:884,751...938,901
Ensembl chrNW_004936784:884,751...938,282 		JBrowse link
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chrNW_004936594:5,410,975...5,417,958
Ensembl chrNW_004936594:5,410,948...5,417,988 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chrNW_004936547:286,267...310,062
Ensembl chrNW_004936547:286,267...310,062 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 ISO SMPDB SMP:00649 NCBI chrNW_004936489:11,534,095...11,556,759
Ensembl chrNW_004936489:11,534,095...11,556,745 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chrNW_004936489:11,605,403...11,627,786
Ensembl chrNW_004936489:11,594,480...11,627,786 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chrNW_004936489:11,693,755...11,774,380
Ensembl chrNW_004936489:11,693,755...11,772,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3945
    drug pathway 362
      anti-infective drug pathway 21
        lamivudine drug pathway 15
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 15
paths to the root