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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00649 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00649 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00649 NCBI chr11:64,089,149...64,309,831 JBrowse link
G ABCG2A ATP binding cassette subfamily G member 2A ISO SMPDB SMP:00649 NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393 		JBrowse link
G CHPT1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chr 5:82,500,925...82,544,390
Ensembl chr 5:82,497,648...82,544,264 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr 6:164,161,439...164,197,429
Ensembl chr 6:164,162,518...164,197,379 		JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chr 8:67,706,661...67,736,743 JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chr12:6,162,420...6,164,143
Ensembl chr12:6,162,243...6,164,140 		JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chr13:133,794,337...133,851,004
Ensembl chr13:133,818,761...133,850,996 		JBrowse link
G PCYT2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chr12:1,084,416...1,091,031
Ensembl chr12:1,084,410...1,091,029 		JBrowse link
G PGK1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chr  X:62,187,472...62,210,321
Ensembl chr  X:62,187,434...62,210,705 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO SMPDB SMP:00649 NCBI chr 1:7,340,442...7,365,543
Ensembl chr 1:7,340,126...7,365,520 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chr 1:7,289,278...7,323,418
Ensembl chr 1:7,289,831...7,323,146 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chr 1:7,105,486...7,207,395
Ensembl chr 1:7,110,074...7,207,401 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4041
    drug pathway 384
      anti-infective drug pathway 25
        lamivudine drug pathway 17
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 17
paths to the root