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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.

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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00649 NCBI chrNW_004624782:449,217...590,306
Ensembl chrNW_004624782:449,288...591,310 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chrNW_004624737:11,593,701...11,686,790
Ensembl chrNW_004624737:11,593,864...11,688,460 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 NCBI chrNW_004624795:6,516,384...6,558,332
Ensembl chrNW_004624795:6,516,224...6,557,892 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00649 NCBI chrNW_004624879:1,811,686...2,060,221
Ensembl chrNW_004624879:1,811,651...2,060,099 		JBrowse link
G Chpt1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chrNW_004624750:6,358,030...6,372,391
Ensembl chrNW_004624750:6,358,030...6,372,546 		JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chrNW_004624859:5,452,694...5,495,840 JBrowse link
G Dck deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chrNW_004624890:2,335,064...2,367,826
Ensembl chrNW_004624890:2,335,081...2,368,653 		JBrowse link
G LOC101697399 sulfotransferase 1A1 ISO SMPDB SMP:00649 NCBI chrNW_004624782:13,079,596...13,094,149 JBrowse link
G Nt5c 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chrNW_004624801:4,952,736...4,954,660
Ensembl chrNW_004624801:4,952,736...4,954,639 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chrNW_004624730:61,417,030...61,466,028
Ensembl chrNW_004624730:61,418,013...61,466,016 		JBrowse link
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chrNW_004624801:10,746,551...10,753,221
Ensembl chrNW_004624801:10,746,373...10,753,289 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chrNW_004624836:2,657,320...2,676,124
Ensembl chrNW_004624836:2,653,474...2,676,766 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chrNW_004624855:2,623,595...2,661,739
Ensembl chrNW_004624855:2,623,547...2,659,742 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chrNW_004624855:2,402,096...2,516,249
Ensembl chrNW_004624855:2,399,671...2,516,237 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    drug pathway 349
      anti-infective drug pathway 18
        lamivudine drug pathway 14
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 14
paths to the root