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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A ISO SMPDB SMP:00649 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 ISO SMPDB SMP:00649 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 ISO SMPDB SMP:00649 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 ISO SMPDB SMP:00649 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 ISO SMPDB SMP:00649 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) ISO SMPDB SMP:00649 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Chpt1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chr10:88,305,376...88,339,855
Ensembl chr10:88,288,607...88,339,935 		JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr 4:114,817,810...114,844,425
Ensembl chr 4:114,816,533...114,844,438 		JBrowse link
G Dck deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chr 5:88,912,872...88,931,136
Ensembl chr 5:88,912,855...88,931,140 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr11:93,849,751...93,859,341
Ensembl chr11:93,847,805...93,859,347 		JBrowse link
G Nt5c 5',3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chr11:115,381,251...115,382,659
Ensembl chr11:115,381,246...115,382,688 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha isoform ISO SMPDB SMP:00649 NCBI chr16:32,249,739...32,293,883
Ensembl chr16:32,249,739...32,293,888 		JBrowse link
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chr11:120,500,888...120,508,784
Ensembl chr11:120,500,913...120,508,762 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chr  X:105,230,706...105,247,305
Ensembl chr  X:105,230,706...105,247,305 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 ISO SMPDB SMP:00649 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 ISO SMPDB SMP:00649 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 ISO SMPDB SMP:00649 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591 		JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 ISO SMPDB SMP:00649 NCBI chr 7:126,272,042...126,289,615
Ensembl chr 7:126,272,037...126,275,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    drug pathway 402
      anti-infective drug pathway 30
        lamivudine drug pathway 18
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 18
paths to the root