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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 EXP SMPDB SMP:00649 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) EXP SMPDB SMP:00649 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 EXP SMPDB SMP:00649 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 EXP SMPDB SMP:00649 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) EXP SMPDB SMP:00649 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) EXP SMPDB SMP:00649 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G CHPT1 choline phosphotransferase 1 EXP SMPDB SMP:00649 NCBI chr12:101,697,640...101,729,074
Ensembl chr12:101,696,947...101,744,140 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 EXP SMPDB SMP:00649 NCBI chr 1:47,333,790...47,378,839
Ensembl chr 1:47,333,790...47,394,866 		JBrowse link
G DCK deoxycytidine kinase EXP SMPDB SMP:00649 NCBI chr 4:70,993,649...71,030,914
Ensembl chr 4:70,992,538...71,030,914 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 EXP SMPDB SMP:00649 NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic EXP SMPDB SMP:00649 NCBI chr17:75,130,228...75,131,742
Ensembl chr17:75,130,225...75,131,757 		JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline EXP SMPDB SMP:00649 NCBI chr 3:196,234,368...196,287,726
Ensembl chr 3:196,214,222...196,287,957 		JBrowse link
G PCYT2 phosphate cytidylyltransferase 2, ethanolamine EXP SMPDB SMP:00649 NCBI chr17:81,900,958...81,911,399
Ensembl chr17:81,900,958...81,911,432 		JBrowse link
G PGK1 phosphoglycerate kinase 1 EXP SMPDB SMP:00649 NCBI chr  X:78,104,248...78,129,295
Ensembl chr  X:77,910,739...78,129,295 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 EXP SMPDB SMP:00649 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 EXP SMPDB SMP:00649 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 EXP SMPDB SMP:00649 NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 EXP SMPDB SMP:00649 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    drug pathway 412
      anti-infective drug pathway 29
        lamivudine drug pathway 18
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 18
paths to the root