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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.

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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00649 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00649 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00649 NCBI chr 3:73,821,887...74,106,617
Ensembl chr 3:73,821,134...74,106,579 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00649 NCBI chr 7:36,458,110...36,599,753 JBrowse link
G CHPT1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chr11:96,951,836...96,981,560
Ensembl chr11:96,952,051...96,981,431 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr20:85,541,796...85,584,167
Ensembl chr20:85,541,205...85,584,068 		JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chr 7:19,503,855...19,535,355
Ensembl chr 7:19,504,038...19,535,674 		JBrowse link
G LOC103242912 nucleoside diphosphate kinase A ISO SMPDB SMP:00649 NCBI chr16:42,186,039...42,195,608
Ensembl chr16:42,185,260...42,195,616 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chr16:46,531,820...46,533,763
Ensembl chr16:46,532,216...46,535,736 		JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chr15:90,905,691...90,944,485 JBrowse link
G PCYT2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chr16:73,777,641...73,784,800
Ensembl chr16:73,776,092...73,784,724 		JBrowse link
G PGK1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chr  X:67,072,029...67,093,881 JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO SMPDB SMP:00649 NCBI chr13:87,744,600...87,780,846
Ensembl chr13:87,745,023...87,781,073 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chr13:87,835,077...87,881,410
Ensembl chr13:87,833,430...87,881,081 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chr13:87,971,305...88,076,468
Ensembl chr13:87,971,392...88,074,946 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    drug pathway 383
      anti-infective drug pathway 27
        lamivudine drug pathway 17
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 17
paths to the root