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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00649 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00649 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 NCBI chr 9:26,551,953...26,596,330
Ensembl chr 9:26,551,268...26,595,646 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 ISO SMPDB SMP:00649 NCBI chr22:45,767,033...46,013,577
Ensembl chr22:45,765,835...46,013,505 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 ISO SMPDB SMP:00649 NCBI chr32:11,443,778...11,517,674
Ensembl chr32:11,443,780...11,517,674 		JBrowse link
G CHPT1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chr15:40,602,570...40,631,422 JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr15:13,324,235...13,357,387
Ensembl chr15:13,326,185...13,358,152 		JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chr13:60,206,742...60,236,338
Ensembl chr13:60,205,937...60,235,678 		JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in ISO SMPDB SMP:00649 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chr 9:5,342,793...5,344,432
Ensembl chr 9:5,343,378...5,344,380 		JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chr33:29,363,282...29,414,635
Ensembl chr33:29,358,452...29,430,424 		JBrowse link
G PCYT2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chr 9:383,714...390,164
Ensembl chr 9:376,445...442,919 		JBrowse link
G PGK1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chr  X:60,374,743...60,396,244
Ensembl chr  X:60,374,754...60,423,947 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO SMPDB SMP:00649 NCBI chr 1:49,268,978...49,296,522 JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chr 1:49,407,949...49,496,627
Ensembl chr 1:49,407,966...49,496,620 		JBrowse link
G SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 ISO SMPDB SMP:00649 NCBI chr 6:18,176,156...18,179,492
Ensembl chr 6:18,176,355...18,179,489 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4046
    drug pathway 379
      anti-infective drug pathway 27
        lamivudine drug pathway 18
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 18
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