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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.

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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00649 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00649 NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 NCBI chrNW_004955451:11,087,246...11,130,108
Ensembl chrNW_004955451:11,087,570...11,130,482 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00649 NCBI chrNW_004955404:14,700,808...14,927,944
Ensembl chrNW_004955404:14,700,808...14,928,617 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00649 NCBI chrNW_004955474:12,365,903...12,408,715 JBrowse link
G Chpt1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chrNW_004955405:37,081,024...37,093,798 JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chrNW_004955464:11,179,432...11,213,147 JBrowse link
G Dck deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chrNW_004955447:2,031,851...2,067,005
Ensembl chrNW_004955447:2,031,258...2,067,210 		JBrowse link
G Nt5c 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chrNW_004955553:2,011,549...2,014,209
Ensembl chrNW_004955553:2,011,738...2,013,443 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chrNW_004955420:12,464,857...12,513,017
Ensembl chrNW_004955420:12,464,857...12,500,574 		JBrowse link
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chrNW_004955506:1,258,993...1,266,108
Ensembl chrNW_004955506:1,256,770...1,266,762 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chrNW_004955557:1,566,534...1,584,799 JBrowse link
G Slc22a2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chrNW_004955439:20,567,241...20,608,281
Ensembl chrNW_004955439:20,567,212...20,609,105 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chrNW_004955439:20,367,324...20,476,891
Ensembl chrNW_004955439:20,367,333...20,476,891 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    drug pathway 348
      anti-infective drug pathway 18
        lamivudine drug pathway 15
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 15
paths to the root