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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:lamivudine drug pathway
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Accession:PW:0001430 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of lamivudine, a reverse transcriptase enzyme inhibitor used for the treatment of HIV type 1 and 2 and Hepatitis B virus. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00649 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00649
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chr10:96,385,534...96,458,571
Ensembl chr10:99,889,160...99,947,270 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 Ensembl chr17:49,603,268...49,659,318 JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00649 NCBI chr13:76,193,929...76,476,119
Ensembl chr13:95,349,915...95,582,058 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00649 NCBI chr 4:80,379,108...80,446,641
Ensembl chr 4:91,101,321...91,170,157 		JBrowse link
G CHPT1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chr12:99,278,842...99,311,790
Ensembl chr12:102,692,554...102,711,745 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr 1:46,642,602...46,673,568 JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chr 4:53,193,475...53,230,708
Ensembl chr 4:59,536,997...59,574,537 		JBrowse link
G LOC100969764 sulfotransferase 1A1 ISO SMPDB SMP:00649
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr17:45,243,588...45,252,135
Ensembl chr17:50,113,622...50,131,636 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chr17:69,077,021...69,078,998 JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chr 3:193,574,603...193,633,601
Ensembl chr 3:203,517,951...203,576,854 		JBrowse link
G PCYT2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chr17:76,309,798...76,317,054
Ensembl chr17:82,010,262...82,018,515 		JBrowse link
G PGK1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chr  X:67,280,269...67,302,307
Ensembl chr  X:77,391,805...77,414,459 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO SMPDB SMP:00649 NCBI chr 6:158,004,545...158,046,428
Ensembl chr 6:163,014,663...163,054,681 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chr 6:158,058,226...158,150,917
Ensembl chr 6:163,065,317...163,158,931 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chr 6:158,240,390...158,344,338
Ensembl chr 6:163,247,643...163,349,735 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    drug pathway 395
      anti-infective drug pathway 28
        lamivudine drug pathway 18
          lamivudine pharmacodynamics pathway 0
          lamivudine pharmacokinetics pathway 18
paths to the root